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Database: UniProt
Entry: A0A1S3C4X4_CUCME
LinkDB: A0A1S3C4X4_CUCME
Original site: A0A1S3C4X4_CUCME 
ID   A0A1S3C4X4_CUCME        Unreviewed;       296 AA.
AC   A0A1S3C4X4;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=Probable magnesium transporter {ECO:0000256|RuleBase:RU363078};
GN   Name=LOC103496891 {ECO:0000313|RefSeq:XP_008457149.1};
OS   Cucumis melo (Muskmelon).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX   NCBI_TaxID=3656 {ECO:0000313|Proteomes:UP000089565, ECO:0000313|RefSeq:XP_008457149.1};
RN   [1] {ECO:0000313|Proteomes:UP000089565}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. DHL92 {ECO:0000313|Proteomes:UP000089565};
RX   PubMed=22753475; DOI=10.1073/pnas.1205415109;
RA   Garcia-Mas J., Benjak A., Sanseverino W., Bourgeois M., Mir G.,
RA   Gonzalez V.M., Henaff E., Camara F., Cozzuto L., Lowy E., Alioto T.,
RA   Capella-Gutierrez S., Blanca J., Canizares J., Ziarsolo P.,
RA   Gonzalez-Ibeas D., Rodriguez-Moreno L., Droege M., Du L.,
RA   Alvarez-Tejado M., Lorente-Galdos B., Mele M., Yang L., Weng Y.,
RA   Navarro A., Marques-Bonet T., Aranda M.A., Nuez F., Pico B., Gabaldon T.,
RA   Roma G., Guigo R., Casacuberta J.M., Arus P., Puigdomenech P.;
RT   "The genome of melon (Cucumis melo L.).";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:11872-11877(2012).
RN   [2] {ECO:0000313|RefSeq:XP_008457149.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Acts as a Mg(2+) transporter. Can also transport other
CC       divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but
CC       to a much less extent than Mg(2+). {ECO:0000256|ARBA:ARBA00025284,
CC       ECO:0000256|RuleBase:RU363078}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738,
CC       ECO:0000256|RuleBase:RU363078}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU363078};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU363078}. Early
CC       endosome {ECO:0000256|RuleBase:RU363078}. Endosome
CC       {ECO:0000256|ARBA:ARBA00004177}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the NIPA (TC 2.A.7) family.
CC       {ECO:0000256|ARBA:ARBA00007001, ECO:0000256|RuleBase:RU363078}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU363078}.
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DR   RefSeq; XP_008457149.1; XM_008458927.2.
DR   AlphaFoldDB; A0A1S3C4X4; -.
DR   GeneID; 103496891; -.
DR   OrthoDB; 53219at2759; -.
DR   Proteomes; UP000089565; Unplaced.
DR   GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   InterPro; IPR008521; Mg_trans_NIPA.
DR   PANTHER; PTHR12570:SF20; MAGNESIUM TRANSPORTER NIPA1-RELATED; 1.
DR   PANTHER; PTHR12570; UNCHARACTERIZED; 1.
DR   Pfam; PF05653; Mg_trans_NIPA; 1.
DR   SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|RuleBase:RU363078};
KW   Endosome {ECO:0000256|RuleBase:RU363078};
KW   Ion transport {ECO:0000256|RuleBase:RU363078};
KW   Magnesium {ECO:0000256|RuleBase:RU363078};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363078};
KW   Reference proteome {ECO:0000313|Proteomes:UP000089565};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU363078};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU363078}; Transport {ECO:0000256|RuleBase:RU363078}.
FT   TRANSMEM        54..72
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363078"
FT   TRANSMEM        79..100
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363078"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363078"
FT   TRANSMEM        138..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363078"
FT   TRANSMEM        175..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363078"
FT   TRANSMEM        211..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363078"
FT   TRANSMEM        244..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU363078"
FT   REGION          266..296
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        274..296
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   296 AA;  32515 MW;  A8A47918B9CC68E4 CRC64;
     MGISSDNVRG FLFAVSSSVF IGSSTIIKKK GLIKSGAAGT RAAYGGFSYL CEPWWWAGMI
     TLIVGETANF VAYAYAPAIL VTPLGALSII FSAVLAHFML KEKLHIFGIL GCVLCVVGST
     TIVLHAPLEK KIESVKEVWH LATEPVFLVY SFLVMFVVAV LIFKYAPRYG QSHMIIYVGI
     CSLMGSLTVM SVKAVAIAAK LTFEGMNQFK YFETWFFSVF VVGCCILQVI YLNKDWDTQS
     ATQIATEVCG FITILSGTFL LHKTKDMGKG PATQPPLFQT QSHPHQNQNL YTTRTL
//
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