ID A0A1S3C4X4_CUCME Unreviewed; 296 AA.
AC A0A1S3C4X4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Probable magnesium transporter {ECO:0000256|RuleBase:RU363078};
GN Name=LOC103496891 {ECO:0000313|RefSeq:XP_008457149.1};
OS Cucumis melo (Muskmelon).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX NCBI_TaxID=3656 {ECO:0000313|Proteomes:UP000089565, ECO:0000313|RefSeq:XP_008457149.1};
RN [1] {ECO:0000313|Proteomes:UP000089565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DHL92 {ECO:0000313|Proteomes:UP000089565};
RX PubMed=22753475; DOI=10.1073/pnas.1205415109;
RA Garcia-Mas J., Benjak A., Sanseverino W., Bourgeois M., Mir G.,
RA Gonzalez V.M., Henaff E., Camara F., Cozzuto L., Lowy E., Alioto T.,
RA Capella-Gutierrez S., Blanca J., Canizares J., Ziarsolo P.,
RA Gonzalez-Ibeas D., Rodriguez-Moreno L., Droege M., Du L.,
RA Alvarez-Tejado M., Lorente-Galdos B., Mele M., Yang L., Weng Y.,
RA Navarro A., Marques-Bonet T., Aranda M.A., Nuez F., Pico B., Gabaldon T.,
RA Roma G., Guigo R., Casacuberta J.M., Arus P., Puigdomenech P.;
RT "The genome of melon (Cucumis melo L.).";
RL Proc. Natl. Acad. Sci. U.S.A. 109:11872-11877(2012).
RN [2] {ECO:0000313|RefSeq:XP_008457149.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Acts as a Mg(2+) transporter. Can also transport other
CC divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but
CC to a much less extent than Mg(2+). {ECO:0000256|ARBA:ARBA00025284,
CC ECO:0000256|RuleBase:RU363078}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738,
CC ECO:0000256|RuleBase:RU363078}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU363078};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU363078}. Early
CC endosome {ECO:0000256|RuleBase:RU363078}. Endosome
CC {ECO:0000256|ARBA:ARBA00004177}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NIPA (TC 2.A.7) family.
CC {ECO:0000256|ARBA:ARBA00007001, ECO:0000256|RuleBase:RU363078}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU363078}.
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DR RefSeq; XP_008457149.1; XM_008458927.2.
DR AlphaFoldDB; A0A1S3C4X4; -.
DR GeneID; 103496891; -.
DR OrthoDB; 53219at2759; -.
DR Proteomes; UP000089565; Unplaced.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR008521; Mg_trans_NIPA.
DR PANTHER; PTHR12570:SF20; MAGNESIUM TRANSPORTER NIPA1-RELATED; 1.
DR PANTHER; PTHR12570; UNCHARACTERIZED; 1.
DR Pfam; PF05653; Mg_trans_NIPA; 1.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|RuleBase:RU363078};
KW Endosome {ECO:0000256|RuleBase:RU363078};
KW Ion transport {ECO:0000256|RuleBase:RU363078};
KW Magnesium {ECO:0000256|RuleBase:RU363078};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363078};
KW Reference proteome {ECO:0000313|Proteomes:UP000089565};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU363078};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363078}; Transport {ECO:0000256|RuleBase:RU363078}.
FT TRANSMEM 54..72
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363078"
FT TRANSMEM 79..100
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363078"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363078"
FT TRANSMEM 138..163
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363078"
FT TRANSMEM 175..199
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363078"
FT TRANSMEM 211..232
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363078"
FT TRANSMEM 244..261
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363078"
FT REGION 266..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..296
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 296 AA; 32515 MW; A8A47918B9CC68E4 CRC64;
MGISSDNVRG FLFAVSSSVF IGSSTIIKKK GLIKSGAAGT RAAYGGFSYL CEPWWWAGMI
TLIVGETANF VAYAYAPAIL VTPLGALSII FSAVLAHFML KEKLHIFGIL GCVLCVVGST
TIVLHAPLEK KIESVKEVWH LATEPVFLVY SFLVMFVVAV LIFKYAPRYG QSHMIIYVGI
CSLMGSLTVM SVKAVAIAAK LTFEGMNQFK YFETWFFSVF VVGCCILQVI YLNKDWDTQS
ATQIATEVCG FITILSGTFL LHKTKDMGKG PATQPPLFQT QSHPHQNQNL YTTRTL
//