ID A0A1S3CAU2_CUCME Unreviewed; 220 AA.
AC A0A1S3CAU2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 20 {ECO:0000256|RuleBase:RU364152};
DE AltName: Full=Mediator complex subunit 20 {ECO:0000256|RuleBase:RU364152};
GN Name=LOC103498750 {ECO:0000313|RefSeq:XP_008459719.1};
GN Synonyms=MED20 {ECO:0000256|RuleBase:RU364152};
OS Cucumis melo (Muskmelon).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Cucurbitales; Cucurbitaceae; Benincaseae; Cucumis.
OX NCBI_TaxID=3656 {ECO:0000313|Proteomes:UP000089565, ECO:0000313|RefSeq:XP_008459719.1};
RN [1] {ECO:0000313|Proteomes:UP000089565}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. DHL92 {ECO:0000313|Proteomes:UP000089565};
RX PubMed=22753475; DOI=10.1073/pnas.1205415109;
RA Garcia-Mas J., Benjak A., Sanseverino W., Bourgeois M., Mir G.,
RA Gonzalez V.M., Henaff E., Camara F., Cozzuto L., Lowy E., Alioto T.,
RA Capella-Gutierrez S., Blanca J., Canizares J., Ziarsolo P.,
RA Gonzalez-Ibeas D., Rodriguez-Moreno L., Droege M., Du L.,
RA Alvarez-Tejado M., Lorente-Galdos B., Mele M., Yang L., Weng Y.,
RA Navarro A., Marques-Bonet T., Aranda M.A., Nuez F., Pico B., Gabaldon T.,
RA Roma G., Guigo R., Casacuberta J.M., Arus P., Puigdomenech P.;
RT "The genome of melon (Cucumis melo L.).";
RL Proc. Natl. Acad. Sci. U.S.A. 109:11872-11877(2012).
RN [2] {ECO:0000313|RefSeq:XP_008459719.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC the regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364152}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364152}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364152}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 20 family.
CC {ECO:0000256|ARBA:ARBA00010743, ECO:0000256|RuleBase:RU364152}.
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DR RefSeq; XP_008459719.1; XM_008461497.2.
DR AlphaFoldDB; A0A1S3CAU2; -.
DR GeneID; 103498750; -.
DR OrthoDB; 464329at2759; -.
DR Proteomes; UP000089565; Unplaced.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR013921; Mediator_Med20.
DR PANTHER; PTHR12465:SF0; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 20; 1.
DR PANTHER; PTHR12465; UBIQUITIN SPECIFIC PROTEASE HOMOLOG 49; 1.
DR Pfam; PF08612; Med20; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364152};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364152};
KW Reference proteome {ECO:0000313|Proteomes:UP000089565};
KW Transcription {ECO:0000256|RuleBase:RU364152};
KW Transcription regulation {ECO:0000256|RuleBase:RU364152}.
SQ SEQUENCE 220 AA; 25183 MW; 34BE90200EE04287 CRC64;
MPLKWVLHWQ PNAGSTVNSQ ILNEVSQCVE SIHGVKGGKW KATLTFYKPI LRDQNSPAAE
FPRDFLGISL PEQPNKYYLI IRGQRIVLEA DFTIQAIMEK LQSYKLRVAL NFEYQLGDFQ
LRVGKVVPNN SENLRGIVME IEYLPISSME KSRQIMDEFF DVWQEAMSKS SLPGRFMHIE
SNFAEYGLSD FYTPQHTAVQ YGNVMAQLIA TVQAVQSARN
//
