ID A0A1S3CVR8_DIACI Unreviewed; 504 AA.
AC A0A1S3CVR8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=C-terminal-binding protein isoform X1 {ECO:0000313|RefSeq:XP_008468723.1};
GN Name=LOC103506120 {ECO:0000313|RefSeq:XP_008468723.1};
OS Diaphorina citri (Asian citrus psyllid).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Paraneoptera; Hemiptera; Sternorrhyncha; Psylloidea; Psyllidae;
OC Diaphorininae; Diaphorina.
OX NCBI_TaxID=121845 {ECO:0000313|Proteomes:UP000079169, ECO:0000313|RefSeq:XP_008468723.1};
RN [1] {ECO:0000313|RefSeq:XP_008468723.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_008468723.1; XM_008470501.3.
DR AlphaFoldDB; A0A1S3CVR8; -.
DR STRING; 121845.A0A1S3CVR8; -.
DR PaxDb; 121845-A0A1S3CVR8; -.
DR GeneID; 103506120; -.
DR KEGG; dci:103506120; -.
DR OrthoDB; 4204864at2759; -.
DR Proteomes; UP000079169; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR CDD; cd05299; CtBP_dh; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR043322; CtBP.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR029753; D-isomer_DH_CS.
DR InterPro; IPR029752; D-isomer_DH_CS1.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR46029; C-TERMINAL-BINDING PROTEIN; 1.
DR PANTHER; PTHR46029:SF7; C-TERMINAL-BINDING PROTEIN; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
DR PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000079169}.
FT DOMAIN 39..356
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 135..321
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 371..402
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 428..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 380..395
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 504 AA; 53044 MW; 9D4D461341317863 CRC64;
MDKRKMMAKR PRMDSIRGPI SNGPMQTRPL VALLDGRDCS IEMPILKDVA TVAFCDAQST
SEIHEKVLNE AVGALMWHTI ILTKEDLEKF KTLRIIVRIG SGVDNIDVKA AGELGIAVCN
VPGYGVEEVA DTTLCLILNL YRRTYWLANM VREGKKFTGP EQLREAASGC ARIRGDTLGI
VGLGRIGSAV ALRAKAFGFN VIFYDPYLPD GIEKSLGLTR VYTLQDLLFQ SDCVSLHCTL
NEHNHHLINE FTIKQMRPGA FLVNTARGGL VDDDSLAAAL KQGRIRAAAL DVHESEPYNV
FQGIKSNLKD APNILCTPHA AFYSEASCTE LREMAASEIR RAIVGRIPDC LRNCVNKEYF
PSAGGGGLPA GLNYPHAPPG GPVSSGPPGG PPGPGVVPEG INGGSSSLVS RYYAAAAAAA
IGTLPPVQQA HSTTPHDSAI APAPGSERGG GAPPSGSGGG GAPPSGGGPP PNTPAGLPHN
LPLSTADPSN HHPPKPESSE PGVH
//
