ID   A0A1S3E8H2_CICAR        Unreviewed;       800 AA.
AC   A0A1S3E8H2;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Cation/H(+) antiporter 15-like {ECO:0000313|RefSeq:XP_012571296.1};
GN   Name=LOC101506426 {ECO:0000313|RefSeq:XP_012571296.1};
OS   Cicer arietinum (Chickpea) (Garbanzo).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC   NPAAA clade; Hologalegina; IRL clade; Cicereae; Cicer.
OX   NCBI_TaxID=3827 {ECO:0000313|Proteomes:UP000087171, ECO:0000313|RefSeq:XP_012571296.1};
RN   [1] {ECO:0000313|RefSeq:XP_012571296.1}
RP   IDENTIFICATION.
RC   TISSUE=Etiolated seedlings {ECO:0000313|RefSeq:XP_012571296.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC       transporter (TC 2.A.37) family. CHX (TC 2.A.37.4) subfamily.
CC       {ECO:0000256|ARBA:ARBA00038341}.
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DR   RefSeq; XP_012571296.1; XM_012715842.2.
DR   AlphaFoldDB; A0A1S3E8H2; -.
DR   GeneID; 101506426; -.
DR   KEGG; cam:101506426; -.
DR   OrthoDB; 1037349at2759; -.
DR   Proteomes; UP000087171; Chromosome Ca5.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   PANTHER; PTHR32468; CATION/H + ANTIPORTER; 1.
DR   PANTHER; PTHR32468:SF174; CATION_H+ EXCHANGER DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087171};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        48..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        83..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        113..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        144..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        176..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        212..234
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        246..271
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        283..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        333..351
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        363..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        425..448
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          59..444
FT                   /note="Cation/H+ exchanger"
FT                   /evidence="ECO:0000259|Pfam:PF00999"
SQ   SEQUENCE   800 AA;  88907 MW;  661F95E1C4F12B72 CRC64;
     MMELGQDNLI SNSAPDGTES QFGGSFVCHT VNHINSRGYW FGDNPLEFSV PLFMIQIFLM
     FIFTRFSCLI LKPFGQPSFV SNILGGVTLG PSILGHSSAF ANNFFPIKGR NVLDTLAFFG
     FMLFIFLLGV KIDPTIIFRS GKKTFAVGIL CFFIPYSLGG IVASILSHFA SLDEDISMVL
     TAVVEIQCVT AFPVISCLLA ELQILNSEIG RLASSASLVC DVCFSLVLSI KYAVKLSSTK
     SIGVTIGSLF STTLLILFIV FVVHPAALWA IQHTPEGKPV QEIYICVTLI TVIFCGFIGE
     VIGIDAIIVS FLVGLAIPDG PPLGAALVDK LEYFVSVVLL PNLFVIVGLR TDVFAIQKMK
     NVGIIELIIF ISIFGKIIGA LLPLLFSRMP LRDALSLGLI MNCKGTVELA LLINLRLTNV
     MNDELFAIMV LTLVLVTGIV SPIVRALYDP SRRFLAYKRR TILHHQSDQE FRILACIHKQ
     DNVLAILNLL SASNPTETTR IDLVVLQLVK LVGRASSVLV AHIPREKPSE KIFNSFSKFE
     DAYRGKVTLH CYKGISPYAT MHNDVCYLAL EKRTTFIIIP FHKQWIIGGM AESSFAFKQL
     NKNVLDKAPC SVGVLIDRGN QKKFWCGYLN ESTYLVAVFF FGGADDRESL AYAKRMLDQP
     NVNVTLFHFS SSKNIVGGTD RSKRLDTQIL SEFRLSAFRN DRVSYREENV MNGRDVLSVI
     EYMESFYDLV MVGRRHEDSQ LMSELRKWKH GELGTVGEIL ASLNIGAKTS ILVVQQQIRF
     WGSRDPEEST HLRRVNNSNV
//