ID A0A1S3EAH1_CICAR Unreviewed; 996 AA.
AC A0A1S3EAH1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Replication factor C subunit 1 {ECO:0000256|ARBA:ARBA00020401, ECO:0000256|PIRNR:PIRNR036578};
GN Name=LOC101513194 {ECO:0000313|RefSeq:XP_012572832.1};
OS Cicer arietinum (Chickpea) (Garbanzo).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Cicereae; Cicer.
OX NCBI_TaxID=3827 {ECO:0000313|Proteomes:UP000087171, ECO:0000313|RefSeq:XP_012572832.1};
RN [1] {ECO:0000313|RefSeq:XP_012572832.1}
RP IDENTIFICATION.
RC TISSUE=Etiolated seedlings {ECO:0000313|RefSeq:XP_012572832.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Heterotetramer of subunits RFC2, RFC3, RFC4 and RFC5 that can
CC form a complex with RFC1. {ECO:0000256|ARBA:ARBA00011480}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR036578}.
CC -!- SIMILARITY: Belongs to the activator 1 large subunit family.
CC {ECO:0000256|ARBA:ARBA00006116, ECO:0000256|PIRNR:PIRNR036578}.
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DR RefSeq; XP_012572832.1; XM_012717378.2.
DR AlphaFoldDB; A0A1S3EAH1; -.
DR GeneID; 101513194; -.
DR OrthoDB; 6297at2759; -.
DR Proteomes; UP000087171; Chromosome Ca6.
DR GO; GO:0005663; C:DNA replication factor C complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd17752; BRCT_RFC1; 1.
DR CDD; cd18140; HLD_clamp_RFC; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.272.10; -; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR013725; DNA_replication_fac_RFC1_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR012178; RFC1.
DR InterPro; IPR047854; RFC_lid.
DR PANTHER; PTHR23389; CHROMOSOME TRANSMISSION FIDELITY FACTOR 18; 1.
DR PANTHER; PTHR23389:SF6; REPLICATION FACTOR C SUBUNIT 1; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF08519; RFC1; 1.
DR PIRSF; PIRSF036578; RFC1; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48019; post-AAA+ oligomerization domain-like; 1.
DR PROSITE; PS50172; BRCT; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR036578};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR036578};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR036578}; Nucleus {ECO:0000256|PIRNR:PIRNR036578};
KW Reference proteome {ECO:0000313|Proteomes:UP000087171}.
FT DOMAIN 235..316
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 1..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 357..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 903..996
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..92
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..186
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..233
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 916..931
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 939..971
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 996 AA; 107775 MW; 4E838E469FCA22C9 CRC64;
MSDIRKWFMK SHEKTNNAAA NSNQPKKPSP VKPDPDKTVP EGQSSSGRRK TSKYFNTDKP
KPKDEIETGA LPAKRKTMKG NEEDDGDDSV PSTNKKKLAG STPTKKLKSG SGRGIPQKSV
DLEESDEDNE KDDVSPIKSS GRGRGGRGAS TQATGGRGRG VGRGIPKKSA DLEESDEDDE
KNAVSAKSGG RGRGGRGAST QAAGGRGRGG GRGGFMNFGE RKDPPHKGEK VVPEGAPDCL
AGLTFVISGT LDSLEREEAE DLIKRHGGRV TTSVSKKTNY LLCDDDIGGR KSAKAKELGT
SFLTEDGLFD IIRASKPAKT TSKPAKGPSQ EECKKSVNQA VAVPAQSKGP LKAETKVSLS
SCSPSKQAKA KPKTVQSNLM WTEKHRPTNP KDIIGNQSLV SQLRNWLKGW HEQFSNTGGN
KKQGKKLNDP VSKKAVLLSG TPGIGKTTSA KLVCQELGFQ AIEVNASDSR GKADSKIEKG
ISGSNANSIK ELVTNEALGT NMDRSKLSKT VLIMDEVDGM SAGDRGGVAD LIASIKISKI
PIICICNDRY SQKLKSLVNY CLLLSYRKPT KQQMAKKFMD VAKAEGLQVN EIALEELAER
VNGDMRMALN QLQYMGLSMS VINYDDIRKR LLTNAKDEDI SPFTAVDKLF GFNAGKMKMD
ERINLSMSDP DLVPLLIQEN YINYRPSSAG KDDNGVKRMN LIARAAESIA DGDIVNVQIR
RYRQWQLSQT SSVASCILPA SLLHGQREIL EQGERNFNRF GGWLGKNSTM GKNTRLMDDL
HVHILASRES SSGRVTIRLE YLSLLLKKLT EPLKVLPKAE AVEKVVEFMN TYSISQEDFD
TIVELSKFKG HPNPLDGILP AVKSALTKAY KEQSKTRTVR AADLINLPGI KKAPKKRIAA
ILEPADEGTE QGNGGDALDE SEEENTSDND ESDATTGEKL KSELQSLNSK AMHVQFELKG
TGNSSSKKAS GGRGKGASAS AQKVAQTSKA PAKRKR
//
