ID A0A1S3EGK3_CICAR Unreviewed; 3197 AA.
AC A0A1S3EGK3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN Name=LOC101515491 {ECO:0000313|RefSeq:XP_012574081.2};
OS Cicer arietinum (Chickpea) (Garbanzo).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Fabales; Fabaceae; Papilionoideae; 50 kb inversion clade;
OC NPAAA clade; Hologalegina; IRL clade; Cicereae; Cicer.
OX NCBI_TaxID=3827 {ECO:0000313|Proteomes:UP000087171, ECO:0000313|RefSeq:XP_012574081.2};
RN [1] {ECO:0000313|RefSeq:XP_012574081.2}
RP IDENTIFICATION.
RC TISSUE=Etiolated seedlings {ECO:0000313|RefSeq:XP_012574081.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
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DR RefSeq; XP_012574081.2; XM_012718627.2.
DR PaxDb; 3827-XP_004510490-1; -.
DR KEGG; cam:101515491; -.
DR OrthoDB; 722852at2759; -.
DR Proteomes; UP000087171; Chromosome Ca7.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:UniProt.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR011713; Leu-rich_rpt_3.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF580; DISEASE RESISTANCE-LIKE PROTEIN DSC1; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF07725; LRR_3; 1.
DR Pfam; PF00931; NB-ARC; 2.
DR Pfam; PF01582; TIR; 2.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00255; TIR; 2.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS50104; TIR; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000087171}.
FT DOMAIN 6..175
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT DOMAIN 1613..1784
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1179..1216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1257..1304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2711..2734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2756..2819
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2836..2875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2889..2941
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3079..3103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1459..1507
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2666..2693
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1192..1207
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1257..1278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2713..2734
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2756..2780
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2804..2819
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2836..2857
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2902..2916
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3197 AA; 363141 MW; 3A218951B52C3FC6 CRC64;
MRTSTKKYDV FISFRGEDTR AHFTAQLHQA LTNRNIKSYI DYELVKGDEV GPALAKAIQD
SHMSLVVFSE NYATSKWCLD ELLHILQCRE LHGQVVIPVF CNIDPSHVRH QKESYQIAFA
KYDRELANSK SHADKVSEWK AALTLAANLS GWDSRKYRDD SQVIENIVED VLQKLSLMYP
NELKDVVKID ENIELLLKTI PRIGIWGMSG IGKTTIAKQI FAKNFAHYDN VCFLEKVSEE
SQKVGPIIVR NKLLSELLKR EITASDIHGL RKFIKRRLSG KKSFIVLDDV DNATQLDDLC
GVLDDLGPNS RLIITTRDRH MLSGKVDEIY EVTTWKLKDS LMLFSLGAFK QSHPRKGFEF
FSKRAVEYAG GVPLALKVLG SHFCSRNVEF WESELNYYES KGGALHEIQQ VLRVSYNGLS
WREKEMFLDI AFFFKGENKD LVTRILDAFG FNATSGIIIL EDKALISISN NNRIQMHDLL
QKIAFDIVQE KYNDSGKRSR LRDAKDICDV LGNNKGTDAI EGIIFDLSQQ VDLHVRADTF
NVMTKLRFLK FHIPPGKKKL GTVHLPKVMM PFFDKLTYLE WNGYPLKSLP QPFRAEQLIE
IHLPHSNVEY LWYGMQELVN LEAVDLSECK HLINLPDLSG ALKLKQLRLS GCESLCEVQA
SAFSKDTLHT LLLDRCTKLQ SLVSEKHLTS LIKFSVNGCL SLKEFSLSSD SIKKLDLSNT
GIEILHSSIG GMDKLMWLNL EGLNLTNLPN ELSRLRSLTQ LRVSMCSVVT KSKLEAIFDG
LESLTLLHLK DCCNLFELPA NISSLTSLYE LRLDGSSVEK LPASIKYLSG LEVQSLDNCS
KLRCLPELPS SIKEFQANNC TSLVTVSTLK TFSISMIGKK KYISFKNSIK MELDGPSLDR
ITEDAILMMR SAAFHNVLVR KYRFQTHSFN YNSAEVCLPG RKVPTQFKHR STTYSSVTID
VSNSLGFIFS VVVSPYNRTQ HRGYFVEILC QGYSEDGKRR VGYRSWCNHK PFTKLNMDHV
FVWYDPYHSD SILRSIERNI SFEFSVSTYT SSRRELGGLL SIKECGICPI YYSESQRVLS
TGNLDKDLRL ELSEAIQFES RSVKGYDEGE GTDIESFEIG DNKEDTGILN RQFDLNEHCH
SSYECLIVSN DTQVYDKPQK KENWDYDDNS KEMMKFKILP ESTSTKSGEE IGTSSHKQEQ
FEKEEDSTGE GSDVESPFNK EIKETKNLQQ SPLSLVNNLE IPFDSYTNFL QLQEAPKKLN
PNSPMASESS SSKPSASKGS IRRTEEDSSK LSTPAEHSPV DYSEYKRILE EDPLAIMEKL
LSGELSSSSQ PSQSTIQAEA TETQSESIEM LLNRLRQLAF SRNLLKHLPN DVTLEKEVKA
LLVKLNHRAN ELSEKQSSGI TDFTRIFIEA TVNIDEGKLS NDTLQQLKVD HKDAICKLQA
SKDKIIKFEE SITVGEDNIK DMDVQIEDIK VQIRLLEEKA FKVQQEKSKL EDACSKCKEK
RREMVEEAKN IASKTIQACE KIDHVKKKKW ELDSNFEMLE GHYAIMRLLP PFVSRKTPVV
IDLTAETHCT KEEELKNLPI NQLHDPWRRT ETVFWWQCAV PANILSKMSY SKKKHDVFLS
FRGEDTRIGF TKDLYEALRH KSINTYIDYL LKRGEDVWPS LAKAIEDSHV SIIVFSENYA
SSKWCLEELV KILECRRKVH GQVVIPVFYK TDPSHIRNQS GSYEKAFAKH ERDLGENDVD
SKQKVLNWKA ALTEAANISG WDSQTHKVES DLIENIVNDV LQKIQLKYPN ELEGIVGNEK
DCLSVESLIQ RVQILGIWGM GGMGKSTIAK VLFAKLFAQY DFVLFANAKE YSLSKLLSEL
LKEEISPSNV VASTFHMRRL RSNKLFIVLD NVESLDQFQY LCRDYGELSK SSRLIITTRD
RQLLSGRVHC IYEVKQWEDK ESLELFSIEA FKQSHPEKGF EELSQRAIAY AGGVPMALKV
LGSNLRSKDT VFWKSTFRKL DMFPKEEIQK VLKVSYDGLD PLEKKIFLDI AFFFKGEKKD
HVIRILDACG LEASSGIEVL EDKALITISN DSKIQMHDLL KKMGSDIIRK ECGLNPATHI
RLSGSEALEV IKQNKGTSSI EGITLDLSQN NDFPLCSDTF TKMKALRILK FYIPLGQSCN
NAYLNLPIVL EPFSNELRYF EWIGYPFEAL PQHFCAKFLV EIRMPHSNVQ RLWQGMQELD
TLEGIDLSEC RHFVQLPDLS KASRLKWVNL SGCVSLVDLH PSVLGAETLT SLILDRCTKL
RSVKGWKHLF FLEKISIIGC TNLKEFAVSS DLIENLDLSS TGIQKLDLSV GVPHNLKRLN
LEDSRLEHLP KELPSLKYIK ELKISGSGLT VNKQQLHALF DGLRSLQILH LKDCNKVFEL
PDNISVLSEL QELMLVGSNV IRLPESIKHL QQLEILSLEN CREIQYLPEL PPLIKLLNAV
NCMSLVSVSN LKTIATKMMG NAKYISFRNC LNLNGHSLDL IMESLNLTMM SATFQNVSVR
RLRVAVHSYN YTSVEACLPG RRVPRQFRYQ TTTESFITIE LPNHSNLLGF IYSVVVSPAD
GMKKDGARIK CQCNLGEEGI KATWLNTYVT ELNSDHVYLW YDPFHCDSIL KFYEPKLCFE
FCITNDAGEV DGSICIKECG VRPVCVDELQ SVLQELELDS EKKNELKKAM ELESGHRIIL
KSIEKRSTNI IEESDSESSA GKGQQHNTTK PTKGFSRFFS IDKLLHSSFL KVSKSQTKSS
AVRGSKENAK NSTEVVVQVK SKGNKETLVE PDDTLPEFVG SQSDKTNESK EKSKPKSAIF
KLESVEEDIE NESHLNVEMS TGSSSKETGT SHEESITNSA EVFKRKGNVA RPTESDVGLH
LPVMSVVEEN ASDNKSNENN YDLQDSFDET KNKEEKPNIQ GGQIIVPNTN DMINEPDQEK
EDVPIMDLSK PEGEEDRSDE DSFVKLESIL FGSAESSPEA TSSTSDVAVK AALHNLQCLL
ENSLESILSD VELQRKLHIS LECIKQASHE KVSPNVAKLV ENMTSSIKDL FKDFTLNKKV
VEDHISRLQQ REKLMQRVRD GKKQKDLLKK EKSQCEDENE RLEEEGKKLD EKIRILIEQK
KGIEVEKSKL KESMEICEGE KKKLEDEAKN MITESKELMS SIKNSKSLYA AALSKQQKLK
DKWEGFRTAF ADNYGSN
//
