ID A0A1S3EKH8_DIPOR Unreviewed; 364 AA.
AC A0A1S3EKH8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Transmembrane protein 25 isoform X1 {ECO:0000313|RefSeq:XP_012864893.1};
GN Name=Tmem25 {ECO:0000313|RefSeq:XP_012864893.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012864893.1};
RN [1] {ECO:0000313|RefSeq:XP_012864893.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012864893.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_012864893.1; XM_013009439.1.
DR AlphaFoldDB; A0A1S3EKH8; -.
DR STRING; 10020.ENSDORP00000006790; -.
DR GeneID; 105980549; -.
DR KEGG; dord:105980549; -.
DR CTD; 84866; -.
DR OMA; CVCLGRW; -.
DR OrthoDB; 5355824at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR GO; GO:0005764; C:lysosome; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0090394; P:negative regulation of excitatory postsynaptic potential; IEA:Ensembl.
DR GO; GO:0031647; P:regulation of protein stability; IEA:Ensembl.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR042864; TMEM25.
DR PANTHER; PTHR47224; TRANSMEMBRANE PROTEIN 25; 1.
DR PANTHER; PTHR47224:SF1; TRANSMEMBRANE PROTEIN 25; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius, ECO:0000313|RefSeq:XP_012864893.1};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..364
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010178756"
FT TRANSMEM 234..260
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 30..122
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 303..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 364 AA; 39148 MW; 31920AEB1E09E635 CRC64;
MRPPAGPATL PRALLLLPVL LGSGWGELAP QIDGQTWAER ALRENERHAF TCRVAGPGTP
RLAWYLDGRL QEATTSRLVS VGGEAFSGGT STFTVTAQRA QHELNCSLQD PGRGRSANAS
VILNVQFKPE IAQVGAKYPE AQDPGLLVVL FALVRANPPA NVTWIDQDGP VTVNTSDFLV
LDAQNYPWLT NHTVQLQLRS LPHNLSVVAT NDVGVTSASL PAPGLWAARV EVPLLGIVVA
GGLALGTLVG FSTLVACLVC RKEKKIKGPS RRPSLISSDS NNLKLNNVRL PRENMSLPSN
LQLNDLTADP RGKPVEQPVA RNSSRPELLE AETGGLLTSR GFIRLPMLGY IYRVSSVSSD
EIWL
//
