ID A0A1S3ELZ5_DIPOR Unreviewed; 672 AA.
AC A0A1S3ELZ5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Signal recognition particle subunit SRP72 {ECO:0000256|ARBA:ARBA00018350, ECO:0000256|PIRNR:PIRNR038922};
GN Name=Srp72 {ECO:0000313|RefSeq:XP_012864502.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012864502.1};
RN [1] {ECO:0000313|RefSeq:XP_012864502.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012864502.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the signal recognition particle (SRP) complex, a
CC ribonucleoprotein complex that mediates the cotranslational targeting
CC of secretory and membrane proteins to the endoplasmic reticulum (ER).
CC {ECO:0000256|PIRNR:PIRNR038922}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|PIRNR:PIRNR038922}. Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}.
CC -!- SIMILARITY: Belongs to the SRP72 family.
CC {ECO:0000256|ARBA:ARBA00007676, ECO:0000256|PIRNR:PIRNR038922}.
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DR RefSeq; XP_012864502.1; XM_013009048.1.
DR AlphaFoldDB; A0A1S3ELZ5; -.
DR STRING; 10020.ENSDORP00000000156; -.
DR GeneID; 105980287; -.
DR KEGG; dord:105980287; -.
DR CTD; 6731; -.
DR InParanoid; A0A1S3ELZ5; -.
DR OrthoDB; 91080at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IEA:UniProtKB-UniRule.
DR GO; GO:0008312; F:7S RNA binding; IEA:InterPro.
DR GO; GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR InterPro; IPR013699; Signal_recog_part_SRP72_RNA-bd.
DR InterPro; IPR026270; SRP72.
DR InterPro; IPR031545; SRP72_TPR-like.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR14094; SIGNAL RECOGNITION PARTICLE 72; 1.
DR PANTHER; PTHR14094:SF9; SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72; 1.
DR Pfam; PF08492; SRP72; 1.
DR Pfam; PF17004; SRP_TPR_like; 1.
DR Pfam; PF13181; TPR_8; 2.
DR PIRSF; PIRSF038922; SRP72; 1.
DR SMART; SM00028; TPR; 5.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR038922};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274,
KW ECO:0000256|PIRNR:PIRNR038922};
KW Signal recognition particle {ECO:0000256|ARBA:ARBA00023135,
KW ECO:0000256|PIRNR:PIRNR038922};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 227..260
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 533..589
FT /note="Signal recognition particle SRP72 subunit RNA-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF08492"
FT REGION 528..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..586
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 604..645
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..672
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 672 AA; 74785 MW; 7CE3426D99A863D1 CRC64;
MASSGSSGGA SVPALWSEVN RYGQNGDFTR ALKTVNKILQ INKDDITALH CKVICLIQNG
SFKEALNVIN THTKVLTNNS LSFEKAYCEY RLNRIENALK TIENANQQSD KLKELYGQVL
YRLERYDECL AVYRDLVRNS QDDYDEERKT NLSAVVAAQS NWEKVVPENL GLQEGTHELC
YNAACALIGQ GQLNQAMKIL QKAEDLCRRS FSEDSDGTEE DPQAELAIIH GQMAYILQLQ
GRTEEALQLY NQIIKLKPTD VGLLAVIANN IITINKDQNV FDSKKKVKLT NAEGVEFKLS
KKQLQAIEFN KALLAMYTNQ AEQCRKISTS LQSQSPAHLL PVLIQAAQLC REKQHTKAIE
LLQEFSDQHP ENAAEIKLTM AQLKISQGNI SKACLILRSI EELKHKPGMV SALVTMYSHE
EDIDSAIEVF TQAIQWYQNH QPKSPAHLSL VREAANYKLK YGRKKEAISD LEQLWKQNPK
DIHTLAQLIS AYSLVDPEKA KVLSKHLPSS DSMSLKIDVD ALENSPGATY IRKKGGKVTG
DSQPKEQGQG DLKKKKKKKK GKLPKNYDPK VTPDPERWLP MRERSYYRGR KKGKKKDQIG
KGTQGATAGA SSELDASKTV SSPPTSPRPG SAATVSASTS NIIPPRHQKP AGAPATKKKQ
QQKKKKGGKG GW
//
