ID A0A1S3ENP1_DIPOR Unreviewed; 3582 AA.
AC A0A1S3ENP1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Vacuolar protein sorting-associated protein 13C isoform X2 {ECO:0000313|RefSeq:XP_012865549.1};
GN Name=Vps13c {ECO:0000313|RefSeq:XP_012865549.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012865549.1};
RN [1] {ECO:0000313|RefSeq:XP_012865549.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012865549.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lipid droplet {ECO:0000256|ARBA:ARBA00004502}.
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545}.
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DR RefSeq; XP_012865549.1; XM_013010095.1.
DR GeneID; 105981095; -.
DR CTD; 54832; -.
DR OrthoDB; 199953at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0005811; C:lipid droplet; IEA:UniProtKB-SubCell.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR InterPro; IPR015412; Atg2/VPS13_C.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR049424; VPS13_C.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR031646; VPS13_extend_chorein.
DR InterPro; IPR031642; VPS13_mid_RBG.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166:SF125; INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13C; 1.
DR PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR Pfam; PF09333; ATG2-VPS13_C; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF21679; VPS13_C; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF16908; VPS13_ext_chorein; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 3.
DR Pfam; PF06650; VPS13_VAB; 1.
PE 3: Inferred from homology;
KW Lipid droplet {ECO:0000256|ARBA:ARBA00022677};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 3..116
FT /note="Chorein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12624"
FT DOMAIN 139..370
FT /note="Vacuolar protein sorting-associated protein 13
FT extended chorein"
FT /evidence="ECO:0000259|Pfam:PF16908"
FT DOMAIN 569..790
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 1132..1324
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 1647..1744
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 2436..2970
FT /note="Vacuolar protein sorting-associated protein 13 VPS13
FT adaptor binding"
FT /evidence="ECO:0000259|Pfam:PF06650"
FT DOMAIN 3277..3454
FT /note="Vacuolar protein sorting-associated protein 13 DH-
FT like"
FT /evidence="ECO:0000259|Pfam:PF16909"
FT DOMAIN 3460..3541
FT /note="Atg2/VPS13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF09333"
FT DOMAIN 3548..3576
FT /note="Intermembrane lipid transfer protein VPS13 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF21679"
FT REGION 3560..3582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3582 AA; 402428 MW; C6D489EBA9E4EB01 CRC64;
MVLESVVADL LNRFLGDYVE NLDKSQLKLG IWGGNVALDN LQIKENALSE LNVPFKVKAG
QIDKLTLKIP WKNLYGEAVV ATLEGLYLLV VPGASIKYDA EKEEKSLQDS KQKELSRIEE
ALQKAAEKDK PKEAKKDTFL EKLATQVIKN VQVKITDIHI KYEDDVTDPK RPLSFGVTLG
EFSLLTTNEH WTPCILNEAE KIIYKLIKLD SLGAYWNVNC CLSYQRSREQ ILAQLKNEIL
TSRNTPPNYQ YIFQPILASA KLYMNPYAEA ELKTPKLDCN IEVQNIAIEL TKPQYLSMID
FLESMDYMFR NAHYRKYKPY LPLHTNCRQW WKYAIDSVLE VHIRRYTQMW SWSNIKKHRQ
LLKEYKIAYK NKLTQTKVPE ELQKQIQDLE KSLDVFNIIL ARQQAQVEVI RSGQKLRKKS
SDTGEKRGGW FSGFWGKKES KKKDEESLIP ETIDDLMTSE EKDKLFTAIG YSESSYNLTL
PKQYVAHIIT LKLVSTSVII RENKNIPEIL KIQIIGLGTQ VSQRPGAQAM KVEAKLEHWY
ITGLRQQDIV PSLVASIGDT ASSLLNIEFE TNPENSPADQ TLIVQSQPVE VIYDAKTINA
VVEFFQSNKG LDLEQITSAT LTKLEEIKEK TATGLTHMIE TRKVLDLRIN LKPSYLIIPQ
TGFHHEKSDL LILDFGTFEL NSKDQGVQKT TNSSLEEIMD KAYDKFDVEI KSVQLLFARA
EENWRKYRFQ HPSTMHILQP MDIHVELAKA MVEKDIRMAR FKVSGGLPLM HVRISDRKMK
DVLCLINSIP LPQKSSASSP ERQVSSIPVI SVGTKGLLNT SLLLDGLESE SDDEYFDAED
GDSQTVKSTK GSEIKKATEV PNEELINLLL TFEITEVILE FTKQQKEEET ILVFNVAQLG
TEATVRTFDL TAVSYLKKIS LDYHEIQGSR KKPIHLISSS DKPGLDLLKV EYIKADKNGP
SFQTTFEKTE QTFKVAFSSL NLLLQTQALL SSLNYLTTII PSDGQNMEAA KEVQSSADKQ
TNLPLQKVMV SSQDSDIIGF RLFAKLNAFC VTVCDEKINI AEIKIQGLNS SLSLQSRKQS
LFARLENIIV TDVDPKTVHK KAVSIVGNEV FRFNLDLYPD ATAGDSYTDM SKVDGVVSLN
VGCIQIIYLH KFLTSLLNFL NNFQTAKEAL SAATAQAAEK AATSVRDLTQ RSFRVSVNID
LKAPVIIIPQ SSLSNNAVVV DLGLIRVQNQ FSLVSGEDSL NPPVIDRMDV QLTKLKLSRT
VIQASGSHLD VQLLQPINLQ FCVNRNLAAH WYHKVPVLEI KGHLDSMNVC LNQEDLNLLF
RILAENIGEV TEDLDKMKPR LQETGEVKEP CEVSVSRDMF ASEDSPTPIV GEIRSVDIVN
ILLNFEVKEV VVTLMKSAEK KGRPVYELNI LQLGMEARGR TYDMTAEAYL KQVSMRCFDF
TDSKGEPIHI VNSSNVTNEP LLKMLLTKAD SDGPEFKTIH DNTKQRLKVS FSSLDLVLHL
EALLSLMDFL SSAVPSSESS SSEKESELKP LMGESRTIAI KAASSTVSKE DIFDLKVTAE
LNAFNVFVCD QKCNIADIKV HGMNASVSVK SKQTDMFARL QNIIVKNADL LSIHKKAVSI
LGDEVFRFQM TLYPNATEGK AYADMSKVDG KLSLKVGCIQ IVYVHKFFMS LLNFLNNFQA
AKEALSAATA QAAERAASSM KDLAQKSSRL LMDIHLKAPV IIIPQSSVSA NAVIADLGLI
RVANNFNLVP IEDYSLPPVI DKMNIQLTQL KLSRTILQND LSQPDIEILK PVNMLLSIQR
NLSATWYMQL PGMEITGKLK PMQVALSEDD LSVLMKILLE NLGEASSQTS PTQSAQEAVR
VRRDIPSGPD CLKEQDMTNS EPSVDQNVTL QFDFHFESLS VILYNNDINQ ESTLSFHNDS
FRLGELTLHL MASSGKMFKD GSLDVSLKLK TCTLDDLREG IERATSRMID KKDDQDNNRS
MIDISYKQDR NGSQINAVLD KLYVCASVEF LVTVADFFIK AMPQSPENMA KEIQIPSRQT
APGKAKIEKD DSVRPNMTLK AMIIDPEVVF VANLTKADAP ALTASFQCNL SLSTSKLEQM
MEASVRDLKV LACPFLREKR GNNITTVLQP CSLFMEKCTW ASGKQNINIM VKEFIIKISP
IILNTVMTIM AAMSPKAKED ESKETSEEME NLWSIRSIND YNSWFLGVDV ATEITEHFRD
IEHPMIEENC AVSVESIQVT LECGLGHRTV PLLLAESKFS GNIKNWTSLM NAAADMTLQV
HYYNEIHAVW EPLIERVEGK RQWNLRLDVK KNPIQDKSLM PGDDFIPEPQ VAIHISSGDT
MNITISKSCL NVFNNLAKGF SEGAASTFDY ALKDRAPFTV KNAMGIPITV QPNGNLRVMG
SSEKRDVYTV DIGHDLELEY ACAEPSQQGK LSTLSRQESS FFTFTFVPHG YTEVANIPVA
RPGRRLYNVW NPNASHSDSV LVQIDATEGN KVITLRSPLQ IKNHFSIAFT IYKFVKNVKL
LEPIGIAKPE EEFHVPLDSY RGQLFVQPAG ILAHQYKPST TYISWKEELH RSKEVRGMLQ
CPSVEVNFLP LIVNTIALPD ELSYISTHGE DWDPAYLIHL YPPLTLRNLL PYSLRYLLEG
TAETHELAEG SAADVLHSRI SGEIMELVLV KYLGKNWNGH FRICDTLPEF FLVCFSSDSA
EVMTVDLSIH VRRIGSRLVL SVFSPYWLIN KTSRVLQYRS EDIHVKHPAD FRDIILFSFK
KKNIFSKNKV QLKISTSSWS NSFSLDTVGS YGCVKCPANN MEYLVGVSIK MSSFNLSRIV
TLTPFCTIAN KSSLELEVGE IAPDGSIPTN KWSYVASSEC LPFWPENLSG KLCVRVVGCE
GSSKPFFYNR QDNGTLLSLE DLNGGILVDV NIAEHSTVIT FSDYHEGSAP ALIINHTPWA
ILTYKQSGTQ EEVDLPPRKA RLFAWADPTG PRKLTWRYSA NLGEHDLLKD ECGQFPYDAN
SQIHWVSFLD GRQRVLLFTD DVALVSKALQ AEEMEQANHE ITLSLHSLGL SLVNNDNKQE
VSYIGITSSG VVWEMKPKQK WKPFNQKQII LLEQSYQKYQ VSEDRGWIKL DNNFEVNFNK
VPMEMRLPIR CPIKRDFLSG IEVEFKQSPH QRSLRARLYW LQVDNQLPGT MFPVVFHPVA
PPKSIALDSE PKPFIDVSVI TRFNEYSKVL QFKYFMVLIQ EMALKIDQGF LGAVIALFTP
TSDPEAERKR TKLIQQDIDT LNTELMETSM TDMSILSFFE HFHISPVKLH LSLSLGAGGE
ESDKEKQEMI AIHSVNLLLK SIGATLTDVD DLIFKLAYYE VRYQFYKRDQ LIWSVVRHYS
EQFLKQMYVL VLGLDVLGNP FGLIRGLSEG VEALFYEPFQ GAVQGPEEFA EGLVIGVRSL
FGHTVGGAAG VVSRITGSVG KGLAAITMDK EYQQKRREEM GRQPKDFGDS LARGGKGFLR
GVVGGVTGII TKPVEGAKKE GAAGFFKGIG KGLVGAVARP TGGIIDMASS TFQGIQRVAE
STEEVSSLRP PRLIHEDGII RPYDRQESEG SDLFEQELEK QE
//