ID A0A1S3ENV3_DIPOR Unreviewed; 1063 AA.
AC A0A1S3ENV3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Retinoblastoma-like protein 1 {ECO:0000313|RefSeq:XP_012866068.1};
GN Name=Rbl1 {ECO:0000313|RefSeq:XP_012866068.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012866068.1};
RN [1] {ECO:0000313|RefSeq:XP_012866068.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012866068.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000256|ARBA:ARBA00009475}.
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DR RefSeq; XP_012866068.1; XM_013010614.1.
DR AlphaFoldDB; A0A1S3ENV3; -.
DR STRING; 10020.ENSDORP00000016788; -.
DR GeneID; 105981423; -.
DR KEGG; dord:105981423; -.
DR CTD; 5933; -.
DR InParanoid; A0A1S3ENV3; -.
DR OMA; AILCELH; -.
DR OrthoDB; 519973at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR GO; GO:1990841; F:promoter-specific chromatin binding; IEA:Ensembl.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:2000773; P:negative regulation of cellular senescence; IEA:Ensembl.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR CDD; cd20605; CYCLIN_RBL1; 1.
DR Gene3D; 1.10.472.140; -; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 3.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR015030; RB_C.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR PANTHER; PTHR13742; RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED; 1.
DR PANTHER; PTHR13742:SF20; RETINOBLASTOMA-LIKE PROTEIN 1; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR Pfam; PF08934; Rb_C; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SMART; SM01369; Rb_C; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 70..212
FT /note="Retinoblastoma-associated protein N-terminal"
FT /evidence="ECO:0000259|SMART:SM01367"
FT DOMAIN 381..574
FT /note="Retinoblastoma-associated protein A-box"
FT /evidence="ECO:0000259|SMART:SM01368"
FT DOMAIN 796..903
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT DOMAIN 947..1063
FT /note="Retinoblastoma-associated protein C-terminal"
FT /evidence="ECO:0000259|SMART:SM01369"
FT REGION 955..976
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1019..1039
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1063 AA; 120365 MW; DA0BCAC223829D0A CRC64;
MFEDESHAEG AAVVVAAGEV LQALCQELNL DEGSAAEALD DFTAIRGNYS LEGEVIHWLA
CSLYVACRKS IIPTVGKGIM EGNCVSLTRI LRSAKLSLIQ FFSKMKKWMD MSNLPQEFRE
RIERLERNFE VSTVIFKKFE PIFLDVFQNP YEELPKLPRS RKQRRIPCSV KDLFNFCWTL
FVYTKGNFRM IGDDLVNSYH LLLCCLDLIF ANAIMCPNRQ DLLNPSFKGL PSDFHTADFK
ASEEPPCIIA VLCELHDGLL VEAKGIKEHY FKPYISKLFD KKILKGECLL DLSSFTDNNK
AVNKEYEEYV LTVGDFDERI FLGADAEEEI GTPRKFPGDT PLAQTNVECN LQQHFEKKRS
FAPSTPLTGR RYLREKEAAI TPVASATQSV SRLQSIVAGL KNAPSEQLTS IFESCMRNPM
KNIMKIVKEI GETFCQHYTQ STDDQPGSHI DFAVNRLKLA EILYYKMLET VMVQETRRLH
GMDMSVLLEQ DVFHRSLIAC CLEIVLFAYS SPRTFPWIIE ILHLQPFYFY KVIEVVIRSE
EGLSRDMVKH LNSIEEQILE SLAWGHNSTL WEALQLSSDR VPTCEEVIFP NNFEIGNGGN
VQMHLPMIPM SPIMHPRVKE VRTDSGSLRK DMQPLSPISV HERYSSPTAG SAKRRLFRDD
PPKEVLVDKI MTEGTKLKIA PSSITAENIS ISPGQTLLTM ATATVTGSKG HKVTIPMHGV
ANDAGEITLI PISMNSTQAS KVESPVPLTA QSLSSASPQQ THLTNAQEVH LTGISKPKRT
GSLALFYRKV YHLASVRLRD LCLKLDVSNE LRRKIWTCFE FTLVHCPDLM KDRHLDQLLL
CAFYIMAKVT KEERTFQEIM KSYRNQPQAN SHVYRSVLLR SIPKEVVTYN NDLNGDCEMT
AVEMEDATKT PDCSCEPVKE ERGDLIKFYN TIFVGRVKSF ALKYDLSNQE HMMDAPPLSP
FPHIKQQPGS PRRISQQHSV YISPHKNGSS LTPSSALLYR FSGSPSKSLK EINNMIRQGE
QRTKKRSIAI SGDAESPSKR LCQENDDVLL KRLQDVVSER ANH
//