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Database: UniProt
Entry: A0A1S3EP72_DIPOR
LinkDB: A0A1S3EP72_DIPOR
Original site: A0A1S3EP72_DIPOR 
ID   A0A1S3EP72_DIPOR        Unreviewed;       394 AA.
AC   A0A1S3EP72;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   08-MAY-2019, entry version 12.
DE   SubName: Full=ATP-sensitive inward rectifier potassium channel 1 isoform X2 {ECO:0000313|RefSeq:XP_012865272.1};
GN   Name=Kcnj1 {ECO:0000313|RefSeq:XP_012865272.1};
OS   Dipodomys ordii (Ord's kangaroo rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha;
OC   Heteromyidae; Dipodomyinae; Dipodomys.
OX   NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012865272.1};
RN   [1] {ECO:0000313|RefSeq:XP_012865272.1}
RP   IDENTIFICATION.
RC   TISSUE=Kidney {ECO:0000313|RefSeq:XP_012865272.1};
RG   RefSeq;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   RefSeq; XP_012865272.1; XM_013009818.1.
DR   GeneID; 105980853; -.
DR   CTD; 3758; -.
DR   OrthoDB; 956263at2759; -.
DR   Proteomes; UP000081671; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003268; K_chnl_inward-rec_Kir1.1.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF6; PTHR11767:SF6; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000081671};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609, ECO:0000313|RefSeq:XP_012865272.1};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM      6     24       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     86    105       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    159    183       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       46    188       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      195    366       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   SITE        174    174       Role in the control of polyamine-mediated
FT                                channel gating and in the blocking by
FT                                intracellular magnesium.
FT                                {ECO:0000256|PIRSR:PIRSR005465-1}.
SQ   SEQUENCE   394 AA;  45125 MW;  30EA5E1067E14680 CRC64;
     MNPFLGYAFS HMGVVTTLDY IRMFKHLRKW FVAHCFGHSR QRTRLVSKDG RCNIEFGNVD
     AQSRFIFFVD IWTTVLELKW RYKMTVFITA FLGSWFLFGL LWYVVAYVHK DLPEFHPADN
     HTPCVENING MTSAFLFSLE TQVTIGYGFR CVTEQCATAI FLLIFQSILG VIINSFMCGA
     ILAKISRPKK RAKAITFSKH AVISKRGGKL CLLIRVANLR KSLLIGSHIY GKLLKTTVTP
     EGETIILDQT NINFVVDAGN ENLFFISPLT IYHIIDHNSP FFHMAAETLS QQDFELVVFL
     DGTVESTSAT CQVRTSYVPE EVLWGYRFVP IVSKTKEGKY RVDFHNFSKT VEVETPHCAM
     CLYNEKDARA RMKRGYDNPN FILAEVDETD DTKM
//
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