ID A0A1S3ET90_DIPOR Unreviewed; 205 AA.
AC A0A1S3ET90;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Quinolinate phosphoribosyltransferase [decarboxylating] {ECO:0000256|ARBA:ARBA00033102};
GN Name=Qprt {ECO:0000313|RefSeq:XP_012867159.1,
GN ECO:0000313|RefSeq:XP_012867160.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012867159.1};
RN [1] {ECO:0000313|RefSeq:XP_012867159.1, ECO:0000313|RefSeq:XP_012867160.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012867159.1,
RC ECO:0000313|RefSeq:XP_012867160.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in the catabolism of quinolinic acid (QA).
CC {ECO:0000256|ARBA:ARBA00003237}.
CC -!- PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004790}.
CC -!- SIMILARITY: Belongs to the NadC/ModD family.
CC {ECO:0000256|ARBA:ARBA00009400}.
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DR RefSeq; XP_012867159.1; XM_013011705.1.
DR RefSeq; XP_012867160.1; XM_013011706.1.
DR STRING; 10020.ENSDORP00000010476; -.
DR GeneID; 105982187; -.
DR KEGG; dord:105982187; -.
DR CTD; 23475; -.
DR OrthoDB; 5473389at2759; -.
DR UniPathway; UPA00253; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0004514; F:nicotinate-nucleotide diphosphorylase (carboxylating) activity; IEA:InterPro.
DR GO; GO:0009435; P:NAD biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 3.90.1170.20; Quinolinate phosphoribosyl transferase, N-terminal domain; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR027277; NadC/ModD.
DR InterPro; IPR036068; Nicotinate_pribotase-like_C.
DR InterPro; IPR037128; Quinolinate_PRibosylTase_N_sf.
DR InterPro; IPR002638; Quinolinate_PRibosylTrfase_C.
DR InterPro; IPR022412; Quinolinate_PRibosylTrfase_N.
DR PANTHER; PTHR32179; NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]; 1.
DR PANTHER; PTHR32179:SF3; NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]; 1.
DR Pfam; PF01729; QRPTase_C; 1.
DR Pfam; PF02749; QRPTase_N; 1.
DR SUPFAM; SSF51690; Nicotinate/Quinolinate PRTase C-terminal domain-like; 1.
DR SUPFAM; SSF54675; Nicotinate/Quinolinate PRTase N-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 34..97
FT /note="Quinolinate phosphoribosyl transferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02749"
FT DOMAIN 86..190
FT /note="Quinolinate phosphoribosyl transferase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01729"
SQ SEQUENCE 205 AA; 21548 MW; D87C181013E63113 CRC64;
MDAEGLELLL PPTTLAALAD SWLQEDCPGL NFAALVTGAG PAQAALWAKS PGVLAGRPFF
DAIFARLNCQ VSWLLPEGSK LVPVVKVAEA VQAARQVTDF TLKIEVECSC LQEAMQAAEA
GADLLLLDNF KPEELHPTAA AVKAQFPSVT VEASGGVTLN NLPQFCGPQI DVISLGMLTQ
AAPALDFSLK LFAEGTTPVP YPCRS
//
