ID A0A1S3ETF2_DIPOR Unreviewed; 4345 AA.
AC A0A1S3ETF2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Polycystin-1 {ECO:0000313|RefSeq:XP_012866702.1};
GN Name=Pkd1 {ECO:0000313|RefSeq:XP_012866702.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012866702.1};
RN [1] {ECO:0000313|RefSeq:XP_012866702.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012866702.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR RefSeq; XP_012866702.1; XM_013011248.1.
DR STRING; 10020.ENSDORP00000012891; -.
DR GeneID; 105981898; -.
DR KEGG; dord:105981898; -.
DR CTD; 5310; -.
DR InParanoid; A0A1S3ETF2; -.
DR OrthoDB; 52189at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001822; P:kidney development; IEA:InterPro.
DR CDD; cd00037; CLECT; 1.
DR CDD; cd00146; PKD; 12.
DR CDD; cd01752; PLAT_polycystin; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000434; PC1.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR002859; PKD/REJ-like.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR042060; PLAT_polycystin1.
DR InterPro; IPR006228; Polycystin_cat.
DR InterPro; IPR046791; Polycystin_dom.
DR InterPro; IPR014010; REJ_dom.
DR InterPro; IPR002889; WSC_carb-bd.
DR NCBIfam; TIGR00864; PCC; 1.
DR PANTHER; PTHR46730; POLYCYSTIN-1; 1.
DR PANTHER; PTHR46730:SF3; POLYCYSTIN-1; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00801; PKD; 14.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR Pfam; PF02010; REJ; 1.
DR PRINTS; PR00500; POLYCYSTIN1.
DR SMART; SM00034; CLECT; 1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00308; LH2; 1.
DR SMART; SM00369; LRR_TYP; 2.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00089; PKD; 15.
DR SMART; SM00321; WSC; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR SUPFAM; SSF49299; PKD domain; 12.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50093; PKD; 12.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS51111; REJ; 1.
DR PROSITE; PS51212; WSC; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023069};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 3130..3150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3336..3357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3377..3399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3598..3619
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3625..3644
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3712..3731
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3942..3961
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3982..4004
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4029..4049
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4075..4097
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 241..335
FT /note="WSC"
FT /evidence="ECO:0000259|PROSITE:PS51212"
FT DOMAIN 369..423
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 479..595
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 1015..1077
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1107..1186
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1184..1272
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1293..1350
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1367..1440
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1466..1526
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1544..1608
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1630..1692
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1778..1864
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 1890..1948
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 2132..2206
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
FT DOMAIN 2204..2891
FT /note="REJ"
FT /evidence="ECO:0000259|PROSITE:PS51111"
FT DOMAIN 3173..3288
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT REGION 3494..3516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3528..3581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4209..4252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4285..4309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4324..4345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3529..3550
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4233..4247
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4345 AA; 466372 MW; 2CEA0FBCEA9918A2 CRC64;
MDITQLGEGV YLRLQFVFSG LRIKMPSPGP RPSADTPKFL RSAVFTKGPD GALALHAKER
ACALRPSTAA SQCGAAVPGL ACARLLTTYV WNAQMFPWGL PLATLTLIIG IGEQMNSFRF
FIRKALSLPL ITGVHRGDLS HNLLHTLDAG LLANLSALVE LDISDNKIST LEEGVFANLF
NLSEINLSGN PFECDCGLLW LPRWVEERRV RMAPARVATC AGPGPLAGQP LDVTLLSGGC
GEEYIACLPD NSSGTPTVVA LSSAHEGPLE PEACGALCFS ASKGLAALAE QGRCVCGALQ
LPNTSAACQS LCSSLLQPRS PTCSGPTLLR NVFPASPGAT LVGPHGPLAS GRPAAFHIAA
PLPIGSTHWD FGDGSPGVDV AGSAATHRYA LPGRYHVTAV LAMGSSSALL GTEVRVEAAP
AALELLCPAS LHSDESLRIS IRNRGGSALE ATYTILALDE EPVRVVHPLC PSDTEIFPGS
GHCYRLVAEK APWLQAQEQC RTWAGAALAM VDSPTIQRFL VSQVTRGLDV WIGFSSVEGA
EAGLAPQGEA FSLESCQNWL PGEPHPATAQ HCVRLGPAGQ CNTDLCSAPH SYVCELRPGG
PVWDAENFLE GVPDGGLQGP LRPLARQEAL LAPQQPLELI VLPGPSREAF LTAAEFGIQE
LGGPAQLRLQ VFRPSGGAVA PESSSEPENV TEPGPGCLLE EHWCPGANVC VPVDASCHPH
APARGSASGP RLPGVAHTLW REFLFSVPAG PPTRYSVTVH DQDILVLPGD LIGLQHDAGP
GALLQCPLGS NHPGLEVLYF STNASVWLAS LPAQVEGAQT GPACALQLRL ATEQLTVLLG
LTPNPGLQRP GRYKVQATVG NSVSSHNLSC GFSVVSPLTG LRVVHPALLD GHLYIPTNGS
VLVLQVDSGA SATATASWSG GHITAPFEAA CPSVGATFQP DCTGEANHTW FSVLALPRLS
EGEHAVEIVA QNRDSRANLS LRVTAEEPIR GLRAVPSPEA RVLQGVLVRY SPMVESGSDV
VFRWTIDDKQ SLTFHNVVFN VIYQSAAIFK LSLTASNHVS NVTVNYNVSV ERMNRMRGLR
VSAVPAVLPL NATLELMASV LVDAAVEVAF LWTFGDGEQV VGQFKPPYGE AFQVPDPTVA
QVLVEHNATH TYASPGEYNL TVLASNTYEN MTQQVPVSVR PALPSLAVGA SRSVLVVGQP
VTFSPHPRPL SGGILYAWDF GDGSPRLVQS QPAVNHTYLH PGTYRVSLEV NNTVSSVGAY
TDVHVFRELR GLSVHLSPAV EQGAPVAVQA AVETGDNVTW TFDMGDGTMF TGPEPTVQHV
YLRAQNYTVT VVAASPAGQL TQSLPVQVFV LEVLRVEPAT CIPVQPEARL TAHVTGDPAR
YLFDWTFGDG SSNITVQGCP TVTHNFTRSG TFPLALVLSS RVNKAHYFTS ICVEPELGNV
TLQPERQFVR LGDAARLAAC AWPPFPYRYI WAFGTEGAAP TQAGGPDAAF TYREPGSYVV
MVTATNNISA ANASARVEVQ EPVDITAIGV NGSHVLEMGR PYLFSAEGHG RPATYSWELG
DGAQLEGAEV THTYSSAGGF TVAVAGWNEV SRSEARRNVT VQQRIEGLGV NASRTVVPLN
GSVSFGTSLE AGSNVRYSWV LCDRCTPIPG GPTISYTFRS VGTFNIIVTA ENEVGAAQDS
IFIYVLQLIE GLQVVGGGGG CCFPTNHTLQ LQAAVRDGTN ISYSWTAQRD GGPALTGSGK
GFSLTVLEAS TYRIQLRATN MLGSASANRT VEFVEPVGWL GVTASPNPAA VNTSVALLAE
LASGSGVVYT WSMEDGLSWE TWKPSTTHAF SSAGLHPVSV VAGNQLGSAN ATVEVAVQVP
VSGLSIRAGE LDSGFVAVGS SVSFWGQLAA GTDVSWRWSV LGGSKHGQRI ALSFPDAGTF
SVQLNASNAV SWVAAAHTLT VEEPVAGLAL WASSKVVAPG QPVHFQILLA AGSAVSFHLQ
AGGAGPELLP TPHFSRSFSW VGEHVVSVQA ENHVSRAQAQ VRILVLEAIS GLHVLNCCEP
GIATGTEKNF TARVRRGSRA AYAWYFSLQK VQGDSLVILS GRDVTYTPVA AGLLEIHLRA
FNELGSVNLT LTMEVQDVIQ YVALESGRCF TNRSARFEAA TSPSPRRVAY RWDFGDGAPV
QYTEEPWAAH TYLQPGDYRV EVNATNLVSF FVAQATVTVQ VLACREPEVG VALPSQVLMR
RSQRNYLEAH VDLRDCVTYQ AQYRWEVFRA ASCQRLGHSA RVALPGVDVS RPQLVVPRLT
LPVGHYCFVF VVSLGDTPLA RSIQANVTVA AERLVPIIEG GSYRVWSDTQ DLVLDGSKSY
DPNLEDGDQT PLSFHWACVA STQSEAGACA LNFGPRGSST VTIARERLGA GVEYTFSLTV
WKAGRKEESA NQTVLIRSGR VPIVSLECVS CKAQAVYEVS RSSYVYLEGR CQNCSNGSKR
GRWAARTFSN KTLVLDETTT STGGAGMRLV VRQGVLRDGE GYTFTLTVLD RTGEEEGCAS
IRLSPNRPPL GGSCRLSPLE AVRALTTKVH FECTGWRDAE DAGAPLVYAL LLRRCRRGYC
ENFCVYKGSL PAYGAVLPPG FGPHFEVGLA VVVQDQLGAA VVALNRSLAI ILPEPNGSSA
GLAPWLHSLT ASVLPGLLRQ ADPQHVIEYS LALVTVLNEY EQAPDAGVEP SHQRQMRAQV
RKNITETLVS LQVHTVDDIQ QITAALAQCM VASRELVCRS CLKKVLHKLE AMMRILRAET
TQGTATPTAI ADSILNITGD LIHLASSDVQ ALQPLELGAE PPSPMVASKA YNLSSALMCI
LMRSRVLNEE PLTLSGEEIV AQGKRSDPRS LLCYGNTATS GCHFSIPEAF SGALSNVSDV
VQLIILMDSN PFPFGYISNY TVSTKVASMA LQTQAGTQIP IERLATERAI TVKVPSNSDQ
VAQSMRTPAG STIVQPRASV SAVVTPDDSN PEAGLHLQLT YTVLNERYLS EEPEPYLAVY
LHSAPRPNEH NCSADRRISL EALRGADHRL YTFFLAPGTR APGGSYHLNL TSHFHWSPLE
VSVGLYTALC QYFSEEDMMW RTEGLAPLEE TSPRQAVCLT RHLTAFGASL FVPPSRVRFI
FPEPSMGVNY VVLLTCAMCL VTYAAMAVVL HKLDQLDVRR VRAIPFCGKG GRFKYEILVK
TGWGRGSGTT AHVGIMLYGA DSQSGHRHLD GDRAFHRNSL DVFRIATPRS LGSLQKIRVW
HDNKGLSPAW FLQHVIVRDL QSARSTFFLV NDWLSVETEA NGGLVEKEVL AASDEALWHF
RRLLVAELQC GFFDKHIWLS VWDRPPRSRF TRVQRATCCA LLLCLFLGAN AVWYGVVGDA
THSVGPVSSL VPPGADAVAV GLVSSVVVYP VYLAVLFFFR MSRSKVVGGP GPTRSGQPAL
DTDSFLGSPV LNGSFFTLSA LRAEALAGQV RSDFLLDDSK SLVCWPSSEG TLSWPDLLSD
PSIVGSALQQ LAWGPTGHGL GREEDSAPSP AQHLSASDED LIRQALAPTQ DAPSDTDLLT
GLSSTPGEKP ETLLLQRPGE KQLQPSPSGG QPPPARRSVT GPVEGLHKRL LPSWCAPLAH
GLSLLLVAVA VGVSGWVGAS FPPSVGLAWL LSSSCSFLAS FLGWEPLKIL LEALYFSLVA
KRLHPEEDDT LVESPAVTPV SERVPRVRPP HGFALFLAKE EARKVKKLHG MLRSLLVYML
FLLVTLLANY GDAAGHAHAY RLQSAIKQEL DSQAFLAITR SEEFWPWMTS VLLPSVHGDG
PGPELGPPRL RQVRLQEDPL LCTDPPGSGA HAHACSAARG FSTSDYGVGW QSPAHNGSEM
WAYSAPDLLG AWHWGSCAVY DSGGYVQELG LSLEESRRRL GFLQLHNWLD SRSRAVFVEL
TGYSPAVGLH AAVTLGLEFP ATGRALATLS IRPFALPRAS SWLSLPLLTS VSLLLFALYF
LAAEARAWRR EGLARVTRPG AWVRWLLVIL TVAAALVRLA HLGAADRQWG RFLRGRRGRS
VRFTSFDQVA QLSAAARSLA ASLLFLLLLK AAQQLRFVRH WSIFGKTLCR ALPELLGATL
GLAVLGVAYA QLAVLLVSSG MDSFQNAARA IWALCPGARV PALCPAESWY LSPLLCGALW
ALRAWGALRL GAVLLLWRYH ALRGELYRPA WEPQDYEMVE LFLRRLRLWM GFSKVKEFRH
KVRFEGMEPL PSRSSRGSKS PPAAPPPSAG SEPSRPSTSS SSQPDGLRRE PEPSCLHSMF
EALLMQFDRL NQATEDVYQL EQQLQSLQGQ RNGQPRALPP AGRAPGPPRA LAPCLACRAS
RAVGPAANPG RVSLWGKNKV HPSST
//
