ID A0A1S3EU45_DIPOR Unreviewed; 1246 AA.
AC A0A1S3EU45;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Insulin receptor substrate 1 {ECO:0000313|RefSeq:XP_012867445.1};
GN Name=Irs1 {ECO:0000313|RefSeq:XP_012867445.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012867445.1};
RN [1] {ECO:0000313|RefSeq:XP_012867445.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012867445.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_012867445.1; XM_013011991.1.
DR AlphaFoldDB; A0A1S3EU45; -.
DR STRING; 10020.ENSDORP00000011617; -.
DR GeneID; 105982400; -.
DR KEGG; dord:105982400; -.
DR CTD; 3667; -.
DR InParanoid; A0A1S3EU45; -.
DR OrthoDB; 4212441at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0005158; F:insulin receptor binding; IEA:InterPro.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:InterPro.
DR CDD; cd01257; PH_IRS; 1.
DR CDD; cd01204; PTB_IRS; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR039011; IRS.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10614; INSULIN RECEPTOR SUBSTRATE; 1.
DR PANTHER; PTHR10614:SF11; INSULIN RECEPTOR SUBSTRATE 1; 1.
DR Pfam; PF02174; IRS; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00628; INSULINRSI.
DR SMART; SM01244; IRS; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00310; PTBI; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS51064; IRS_PTB; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Receptor {ECO:0000313|RefSeq:XP_012867445.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671}.
FT DOMAIN 12..115
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 158..262
FT /note="IRS-type PTB"
FT /evidence="ECO:0000259|PROSITE:PS51064"
FT REGION 121..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 525..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 680..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 764..940
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1042..1246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..279
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..314
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..427
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 526..547
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..745
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 781..810
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 868..893
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1076..1092
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1104..1118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1198..1213
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1215..1240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1246 AA; 132266 MW; B0B2B454E5B7824A CRC64;
MASPPEADGF SDVRKVGYLR KPKSMHKRFF VLRAASEAGG PARLEYYENE KKWRHKSSAP
KRSIPLESCF NINKRADSKN KHLVALYTRD EHFAIAADSE AEQDSWYQAL LLLHTRAKGH
HHDGSAGSGA GGSCSGSSGV GEAGEDLSFG ETPPGPAFKE VWQVILKPKG LGQTKNLIGI
YRLCLTSKTI SFVKLNSEAA AVVLQLMNIR RCGHSENFFF IEVGRSAVTG PGEFWMQVDD
SVVAQNMHET ILEAMRAMSD EFRPRSKSQS SSNCSNPISV PLRRHHLNNP PPSQVGLTRR
SRTESITATS PASMVGGKPG SFRVRASSDG EGTMSRPASV DGSPVSPSIN RTHAHRHRGS
SRLHPPLNHS RSIPMPSRCS PSATSPVSLS SSSTSGHGST SDCLFPRRSS ASVSGSPSDG
GFISSDEYGS SPCDFRSSFR SVTPDSLGHT PPARGEEELS NYICMGGKGV STLAAPNGHY
VLSRGGNGHR YLPGAAGLGT SPALAVDEAA AVGAADLDNR FRKRTHSAGT SPTISHQKTP
SQSSTEEYTE MMPAYPPGGG SGGRLPGYRH SAFVPTHSYP EEGLELHPLE RRGSHQPHQH
PRPDHHAALH TDDGYMPMSP GVAPLPTGRK GTGDYMPMSP KSVSAPQQII NPVRRHPQRV
DPNGYMMMSP SGSCSPDIGG GGGGGGGGVS GKLWTNGVGG HHPHALAHPK PPADSSSGGK
LLPCTGDYMN MSPVGDSNTS SPSDGYYGPE DKPVLSYYSL PRSFKHTQRP GEPEEGARPQ
HLRLSSSSGR LLYATTAEDS SSSTSSDSLG GGYCGPRPEP GLPHPHHPVL QPHLPRKVDT
AAQTHSRLAR PTRLSLGHPK ASTLPRAREQ PLQPQQQQQQ QQQQQQQQPP EPKSPGEYVN
IEFGSEQPGY FSGPRAPHSS GLSVRCPSQL QPAPREEETG TEEYMNMDLG PGRRAAWQES
GVVEVAKVAG PAPPGAASVC RPTRAVPSSR GDYMTMQMRC SSQSYVDTSP VAPVSYADMR
TGLATVEDVS LPRATAAAPS ASAAVAASPS EPEGAAELPG RASLLGPPQG PGGISAFTRV
NLSPNRSQSA KVIRADPQGC RRRHSSETFS STPAATRAGN TVPFAAGAAV GGSSSSSSSE
EVKRHSSASF ENVWLRPGEL GGGPKETAQG CGAAGGVENG LNYIDLDLVK DFKQRPPERP
PQQQPPAPPN PHQPVGSGES RSTRRSSEDL STYASISFQK QPEDRQ
//