ID A0A1S3EUE6_DIPOR Unreviewed; 781 AA.
AC A0A1S3EUE6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Transducin-like enhancer protein 3 isoform X1 {ECO:0000313|RefSeq:XP_012867545.1};
GN Name=Tle3 {ECO:0000313|RefSeq:XP_012867545.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012867545.1};
RN [1] {ECO:0000313|RefSeq:XP_012867545.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012867545.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the WD repeat Groucho/TLE family.
CC {ECO:0000256|ARBA:ARBA00005969}.
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DR RefSeq; XP_012867545.1; XM_013012091.1.
DR AlphaFoldDB; A0A1S3EUE6; -.
DR STRING; 10020.ENSDORP00000008973; -.
DR GeneID; 105982479; -.
DR KEGG; dord:105982479; -.
DR CTD; 7090; -.
DR InParanoid; A0A1S3EUE6; -.
DR OMA; LTPDANW; -.
DR OrthoDB; 1333122at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:1990907; C:beta-catenin-TCF complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0120163; P:negative regulation of cold-induced thermogenesis; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR005617; Groucho/TLE_N.
DR InterPro; IPR009146; Groucho_enhance.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR10814; TRANSDUCIN-LIKE ENHANCER PROTEIN; 1.
DR PANTHER; PTHR10814:SF24; TRANSDUCIN-LIKE ENHANCER PROTEIN 3; 1.
DR Pfam; PF03920; TLE_N; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR01850; GROUCHOFAMLY.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}; Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 18..143
FT /note="Groucho/TLE N-terminal Q-rich"
FT /evidence="ECO:0000259|Pfam:PF03920"
FT REPEAT 581..622
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 623..664
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 138..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 191..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 26..60
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 151..165
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 191..207
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..261
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..311
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 781 AA; 84117 MW; 961296F4296DF8A9 CRC64;
MYPQGRHPAP HQPGQPGFKF TVAESCDRIK DEFQFLQAQY HSLKVEYDKL ANEKTEMQRH
YVMYYEMSYG LNIEMHKQTE IAKRLNTILA QIMPFLSQEH QQQVAQAVER AKQVTMTELN
AIIGVRGLPS LPFTQQQLQA QHLSHATHGP PVQLPPHPSG LQPPGIPPVT GGSAGLLALG
ALGSQAHLAV KDEKSHHELD HRERDSSANN SVSPSESLRA SEKHRGSADY SMEAKKRKAE
EKDSLSRYDS DGDKSDDLVV DVSNEDPATP RVSPAHSPPE NGLDKARGLK KDAPASPASV
ASSSSTPSSK TKELGHSDKS STPGLKSSTP TPRNDAPTPG TSTTPGLRAM PGKPPGMDPI
GIMASALRAP ISITGSYAAP FAMMSHHEMN GSLTSPSAYA SLHNIPPQMS AAAAAAAAYG
RSPMVSFGAV GFDPHPPMRA TGLPSSLATI PGGKPAYSFH VSADGQIQPV PFPHDALAGP
GIPRHARQIN TLSHGEVVCA VTISNPTRHV YTGGKGCVKI WDISQPGSKS PISQLDCLNR
DNYIRSCKLL PDGRTLIVGG EASTLTIWDL ASPTPRIKAE LTSSAPACYA LAISPDAKVC
FSCCSDGNIA VWDLHNQTLV RQFQGHTDGA SCIDISHDGT KLWTGGLDNT VRSWDLREGR
QLQQHDFTSQ IFSLGYCPTG EWLAVGMESS NVEVLHHTKP DKYQLHLHES CVLSLKFACC
GKWFVSTGKD NLLNAWRTPY GASIFQSKES SSVLSCDISA DDKYIVTGSG DKKATVYEVI
Y
//
