ID   A0A1S3EUG5_DIPOR        Unreviewed;      1129 AA.
AC   A0A1S3EUG5;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=MHC class II transactivator isoform X1 {ECO:0000313|RefSeq:XP_012867052.1};
GN   Name=Ciita {ECO:0000313|RefSeq:XP_012867052.1};
OS   Dipodomys ordii (Ord's kangaroo rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC   Dipodomyinae; Dipodomys.
OX   NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012867052.1};
RN   [1] {ECO:0000313|RefSeq:XP_012867052.1}
RP   IDENTIFICATION.
RC   TISSUE=Kidney {ECO:0000313|RefSeq:XP_012867052.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_012867052.1; XM_013011598.1.
DR   AlphaFoldDB; A0A1S3EUG5; -.
DR   STRING; 10020.ENSDORP00000002129; -.
DR   GeneID; 105982132; -.
DR   KEGG; dord:105982132; -.
DR   CTD; 4261; -.
DR   InParanoid; A0A1S3EUG5; -.
DR   OrthoDB; 5311112at2759; -.
DR   Proteomes; UP000081671; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd00116; LRR_RI; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR008095; MHC_II_transact.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR47189; MHC CLASS II TRANSACTIVATOR; 1.
DR   PANTHER; PTHR47189:SF1; MHC CLASS II TRANSACTIVATOR; 1.
DR   Pfam; PF13516; LRR_6; 2.
DR   Pfam; PF05729; NACHT; 1.
DR   PRINTS; PR01719; MHCIIACTVATR.
DR   SMART; SM00368; LRR_RI; 4.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   PROSITE; PS50837; NACHT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000081671}.
FT   DOMAIN          415..550
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          136..162
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          269..301
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        137..161
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        281..295
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1129 AA;  122366 MW;  F6C8D8EE27822D76 CRC64;
     MRCLAPCPLG PHLPEPQGSG QPGTMEVGLP EGGYLELLNS DTDPLCLYHI CDQMDLAGEE
     IELCSEADPE TINCDQFTRL LCDVEEDEEA GEAYANIAEL DQYVFQDSQM EGLSKDIFIE
     HIGLDEGTCE SVEVPAEVGK RNQKRSLPEE QPLDPKRRKP AETPAVPILT GSFLVGPVGS
     NSPLLCPSPA LFSQEPVPGQ APLEGAVQLT ALPSGSSMNC FHLSAGPFQF ISTLPALPQG
     CWQISESGTN ISGIFIYHGD IPQASQVFPC PGPPVQSLPK SPERPGSTSP FAPSTADLPS
     MPEAALTSRA GVTEDDMSPS PHQGAAEVSV SLPKWPGPVE QFCRSLRDRY QAEPAGLDGL
     LVDVDLVRAR LEKGSNKSQE RELATLDWAE RQPAHGGLAE VLLSTRDRRQ PRETHVIAVL
     GKAGVGKSHW ARAVSRAWAC GQLPQYDFVF HVPCHCLDRP GTTYRLQDLL CPAGLHAQAL
     DDRILSHIVR RSNHVLLILD GFEELEAQDG SCGPVCSEPC SFRGLLAGLF QGKLLRGCTL
     VLTARPRGRL AQCLSKADAL FEVPGFSAEQ ALTYLRRYFE DTGATEDQER ALVLLREQPF
     LSSHGHNPAV CQAVCQLSKV LLRAGAEAQL PCTLTGLYVG LVGPAARDSP PGALASLAEL
     AWELGRRHQS TLREDQFPSA EVRTWAVARG LVRAAPGAVE AGLAFASFPL HCFLGALWLA
     QSSDIKDKKL PQYLALTPRK KRPYDNWLAG APRFLVGLLF QPRARCLGAL LGPAAAAATG
     ADRKRKVLTR YLKRLQPGKL QAARVLELLH CAHEAQDPGI WQHVLQGLPE HLSFLGTRLT
     PPDAHLLGRA LESAGRDFSL DLRSTGLDPS GLGSLVGLSC VTRFRAALSD TTGLWESLRR
     RGETPLLCAA EEKFTIEPFK AKSLKDVEDL GHLVQTPRVT RCSDDPARDL PAVRDLKKLE
     FALGPVLGAQ AFPKLARILP AFSSLQHLDL DSLSENKIGD EGVAQLSATF PWLKALETLN
     LSQNSITDVG ACQLADALPA LAATLLRLSL YNNCICDKGA ESLARVLPDM ESLRVMDVQY
     NKFTAVGAQQ LAASLRKCPH LHTLAMWTPT IPFGVQEHLQ QLDSRISLR
//