ID A0A1S3EY30_DIPOR Unreviewed; 462 AA.
AC A0A1S3EY30;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Interferon regulatory factor 8 isoform X1 {ECO:0000313|RefSeq:XP_012868347.1};
GN Name=Irf8 {ECO:0000313|RefSeq:XP_012868347.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012868347.1};
RN [1] {ECO:0000313|RefSeq:XP_012868347.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012868347.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_012868347.1; XM_013012893.1.
DR AlphaFoldDB; A0A1S3EY30; -.
DR STRING; 10020.ENSDORP00000015017; -.
DR GeneID; 105983119; -.
DR KEGG; dord:105983119; -.
DR CTD; 3394; -.
DR InParanoid; A0A1S3EY30; -.
DR OrthoDB; 3740806at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:UniProt.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:UniProt.
DR CDD; cd00103; IRF; 1.
DR Gene3D; 2.60.200.10; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR019817; Interferon_reg_fac_CS.
DR InterPro; IPR001346; Interferon_reg_fact_DNA-bd_dom.
DR InterPro; IPR019471; Interferon_reg_factor-3.
DR InterPro; IPR017855; SMAD-like_dom_sf.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11949; INTERFERON REGULATORY FACTOR; 1.
DR PANTHER; PTHR11949:SF7; INTERFERON REGULATORY FACTOR 8; 1.
DR Pfam; PF00605; IRF; 1.
DR Pfam; PF10401; IRF-3; 1.
DR PRINTS; PR00267; INTFRNREGFCT.
DR SMART; SM00348; IRF; 1.
DR SMART; SM01243; IRF-3; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00601; IRF_1; 1.
DR PROSITE; PS51507; IRF_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000081671}.
FT DOMAIN 45..152
FT /note="IRF tryptophan pentad repeat"
FT /evidence="ECO:0000259|PROSITE:PS51507"
SQ SEQUENCE 462 AA; 52137 MW; 4A409740A07DBD9D CRC64;
MSCPLPLCSR GHECSVAQGD RTGSLGVFYG AACGRCSSMC DRNGGRRLRQ WLIEQIDSSM
YPGLIWENDE KSMFRIPWKH AGKQDYNQEV DASIFKAWAV FKGKFKEGDK AEPATWKTRL
RCALNKSPDF EEVTDRSQLD ISEPYKVYRI VPEEEQKCKL GLVPPSCVSE VPEMECGRSD
MEELIKEPPV DEYMGVIKRS PSPLEACRSQ LLPDWWAQQA GAGLPLLTGY AAFDTHHQAF
SQMVISFYYG GKLVGQTTTT CPEGCRLSLP QPGPARQCGP EGLELVRFPP ADAVPSERQR
QVTRKLFGHL ERGVLLHSGR RGVFVKRLCQ GRVFYSGNAV VCPGRPNKLE RDEVVQVFDT
SQFFRELQQF YASQSRLPDS RVVLCFGEEF PDMAPVRSKL ILVQVEQLYV RQLMEEAGKS
CGAGPAMQVL EEPQPDQTFR VFPDICASHQ RPFFRENQQI TV
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