ID A0A1S3EZT6_DIPOR Unreviewed; 632 AA.
AC A0A1S3EZT6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Solute carrier organic anion transporter family member {ECO:0000256|RuleBase:RU362056};
GN Name=Slco2b1 {ECO:0000313|RefSeq:XP_012869419.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012869419.1};
RN [1] {ECO:0000313|RefSeq:XP_012869419.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012869419.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362056};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362056}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000256|ARBA:ARBA00009657, ECO:0000256|RuleBase:RU362056}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362056}.
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DR RefSeq; XP_012869419.1; XM_013013965.1.
DR AlphaFoldDB; A0A1S3EZT6; -.
DR STRING; 10020.ENSDORP00000006108; -.
DR GeneID; 105983935; -.
DR KEGG; dord:105983935; -.
DR CTD; 11309; -.
DR InParanoid; A0A1S3EZT6; -.
DR OrthoDB; 2874223at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR NCBIfam; TIGR00805; oat; 1.
DR PANTHER; PTHR11388; ORGANIC ANION TRANSPORTER; 1.
DR PANTHER; PTHR11388:SF87; SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 2B1; 1.
DR Pfam; PF03137; OATP; 2.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|RuleBase:RU362056};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362056};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362056};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362056}; Transport {ECO:0000256|RuleBase:RU362056}.
FT TRANSMEM 117..138
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 145..166
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 253..281
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 302..325
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 483..510
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 574..596
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT DOMAIN 406..466
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT REGION 336..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 604..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 632 AA; 68465 MW; 6CEB7D3431B2D134 CRC64;
MGIVEFNEFS LPVYMDLGTR LPLLLTLDGV HKPGPASEGP QMPDKDTKAT MVTEDTSVGK
ACPEPQDVQS RAFHSIKFFV LCHSLLQLAQ LMISGYLKSS ISTVEKRFGL SSQTSGLLAA
FNEVGNTALI VFVSYFGSRV HRPRMIGCGA VLVALAGLLM SLPHFISDPY RYDHSSPEDM
FQDSKTSFCL PTTSAPASAS SNGSCSSYTE ARHLTVVGIM FAAQTLLGVG GVPIQPFGIS
YIDDFAHHSN SPLYLGLLFA VTMMGPGMAY GLGSLMLRLY VDIDRMPEGG VSLTSKDPRW
VGAWWLGFLI SASLVALAAI PYFFFPKEMS KEKHELRFRK KTLTDPASPV SKGEDCPSEQ
SPEEPTKKQD GLAQLAPDLT VIQFIKGRKA GPTLPAISPA STQPGQRLFP DCSASCSCPP
DDFNPVCDTV AHVEYTTPCH AGCTGHVVQG TLDKSQVFYT NCSCVVGGGP VPAGSCDSDC
SHLVLPFILL VSLGAAVASV THTPSFMLIL RGVKKEDKPL AVGMQFMLLR VLAWMPSPVI
HGSAIDTTCM YWAQTCGRQA VCRYYDHDSF RSRFIGLQFF FKMGSLVCFA LVLAILRQQN
KDTRTKTIVS SPGPEQQLLA SGMEKKPEDS RV
//
