ID A0A1S3EZX4_DIPOR Unreviewed; 404 AA.
AC A0A1S3EZX4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Prolyl 4-hydroxylase subunit alpha-3 {ECO:0000313|RefSeq:XP_012869485.1};
GN Name=P4ha3 {ECO:0000313|RefSeq:XP_012869485.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012869485.1};
RN [1] {ECO:0000313|RefSeq:XP_012869485.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012869485.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
CC Evidence={ECO:0000256|ARBA:ARBA00001961};
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DR RefSeq; XP_012869485.1; XM_013014031.1.
DR AlphaFoldDB; A0A1S3EZX4; -.
DR STRING; 10020.ENSDORP00000024303; -.
DR GeneID; 105983987; -.
DR KEGG; dord:105983987; -.
DR CTD; 283208; -.
DR InParanoid; A0A1S3EZX4; -.
DR OrthoDB; 2899308at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0031418; F:L-ascorbic acid binding; IEA:InterPro.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR Gene3D; 2.60.120.620; q2cbj1_9rhob like domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR InterPro; IPR045054; P4HA-like.
DR InterPro; IPR006620; Pro_4_hyd_alph.
DR InterPro; IPR044862; Pro_4_hyd_alph_FE2OG_OXY.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10869; PROLYL 4-HYDROXYLASE ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10869:SF223; PROLYL 4-HYDROXYLASE SUBUNIT ALPHA-3; 1.
DR Pfam; PF13640; 2OG-FeII_Oxy_3; 1.
DR SMART; SM00702; P4Hc; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 4: Predicted;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671}.
FT DOMAIN 282..389
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
SQ SEQUENCE 404 AA; 45622 MW; ECF71537CD30E7D0 CRC64;
MRLQDVYMLN VKGLARGVFQ RVSGSAVTDL YSPRRLFSLT ADDCFQVGKV AYDMGDYYHA
IPWLEEAVSL FRGSYGEWKT EDEASLEDAL DHLAFAYFQA GNVSSALSLS REFLLYSPDN
KRIARNVLKY ERLLAESSYQ AAAEAVILRP NVPHLQTRDT YEALCQTLGS QPIHYQIPSL
YCSYETSSSP YLLLQPIRKE IIHLQPFVAL YHDFVSDSEA QKIRELAEPW LQRSVVASGE
KQLQVEYRIS KSAWLKDTVD PVLVTLDHRI AALTGLDVQP PYAEYLQVVN YGIGGHYEPH
FDHATSPSSP LYRMKSGNRI ATFMIYLSSV EVGGATAFIY GNFSVPVVKN AALFWWNLHR
SGEGDGDTLH AGCPVLVGDK WVANKWIHEY GQEFRRPCSP NPED
//
