ID A0A1S3F234_DIPOR Unreviewed; 1122 AA.
AC A0A1S3F234;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Double-stranded RNA-specific adenosine deaminase isoform X3 {ECO:0000313|RefSeq:XP_012870668.1};
GN Name=Adar {ECO:0000313|RefSeq:XP_012870668.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012870668.1};
RN [1] {ECO:0000313|RefSeq:XP_012870668.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012870668.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_012870668.1; XM_013015214.1.
DR AlphaFoldDB; A0A1S3F234; -.
DR GeneID; 105984887; -.
DR CTD; 103; -.
DR OrthoDB; 118472at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0003726; F:double-stranded RNA adenosine deaminase activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd19913; DSRM_DRADA_rpt1; 1.
DR CDD; cd19915; DSRM_DRADA_rpt3; 1.
DR Gene3D; 3.30.160.20; -; 3.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR002466; A_deamin.
DR InterPro; IPR044456; ADAR1_DSRM_1.
DR InterPro; IPR044457; ADAR1_DSRM_3.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR042371; Z_dom.
DR PANTHER; PTHR10910:SF107; DOUBLE-STRANDED RNA-SPECIFIC ADENOSINE DEAMINASE; 1.
DR PANTHER; PTHR10910; EUKARYOTE SPECIFIC DSRNA BINDING PROTEIN; 1.
DR Pfam; PF02137; A_deamin; 1.
DR Pfam; PF00035; dsrm; 3.
DR Pfam; PF02295; z-alpha; 2.
DR SMART; SM00552; ADEAMc; 1.
DR SMART; SM00358; DSRM; 3.
DR SMART; SM00550; Zalpha; 2.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 3.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS50141; A_DEAMIN_EDITASE; 1.
DR PROSITE; PS50137; DS_RBD; 3.
DR PROSITE; PS50139; Z_BINDING; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00266}.
FT DOMAIN 130..192
FT /note="Z-binding"
FT /evidence="ECO:0000259|PROSITE:PS50139"
FT DOMAIN 237..301
FT /note="Z-binding"
FT /evidence="ECO:0000259|PROSITE:PS50139"
FT DOMAIN 403..471
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 514..582
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 619..687
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 779..1114
FT /note="A to I editase"
FT /evidence="ECO:0000259|PROSITE:PS50141"
FT REGION 196..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 368..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 196..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1122 AA; 125020 MW; FFEC63F1C34B037F CRC64;
MDPRQGCSFT RYHIQPSQGY EHSRHRWQQP QPGSYSNSFR LQQIEFLKGQ LPEAPLIGRQ
TSSLPPFLPG FWPRFPGPSA PGRHQEIWGV PRGEHLRSQG LHIRPQLPLP CGGVLPPTGV
ERLSSHFQEL NISQDQEQRI LKLLKEKATT VHELARKLRA QKKEVSRVLY SLAKKGKLQK
GTGTPPLWSI TTSFQAQDQP NSVVNPDNQS QGAPDSEPSL KAEEEDPTSD LEDPPEPFDM
AEIKEKICNY LFNVPNSSAL NVARSIGFSK ARDVNTVLID LERQGDVYRQ GATPPIWYLT
DKKRERMQIK RNTHSVPAAT PAAVPETQRN MALSTCHLPP SNKMVTTAKM ENGQGPVIRF
ESRKEGRPMR LKPPVYHNGP SRAGPGLPRC SPYKKLTECQ LKNPISGLLE YAQFASQTCE
FNLIDQSGPP HEPRFKFQVV ISGREFPPAE AGSKKVAKQD AALKAMTILL REAKAKDGGN
LEDLSCCSLE DELEKTEEPE ASTPSATSLF SGKSPVTTLL ECMHKLGNSC EFRLLSKEGP
AHDPKFQYCV AVGAQTFPTV SAPSKKVAKQ MAAEEAMKAL HEEATNMVDN QSGEMESLDN
LEPNKIGRIG ELVRYLNTNP VGGLLEYARS HGFAAEFKLV DQSGPPHEPK FVYQAKVGGR
WFPAVCAHSK KQGKQEAADA ALRVLIGENE KAERMGFTEV TPVTGASLRR TMLLLSRSPD
AHPKTLPLSG STFHDQIAML SHQCFNALTN SFQPSLLGRK ILAAIIMKRD AEDMGVVVSL
GTGNRCVKGD SLSLKGETVN DCHAEIISRR GFIRFLYSEL MKHNHRTAKD SIFELARGGE
KLQIKKTVSF HLYISTAPCG DGALFDKSCS DRAVESTDSR HYPVFENPKQ GKLRTKVENG
EGTIPVESSD IVPTWDGIRL GERLRTMSCS DKILRWNILG LQGALLTHFL QPVYLKSVTL
GYLFSQGHLT RAICCRVTRD GKSFEHGLRY PFTVNHPKVG RVTVYDSKRQ SGKTKETSVN
WCLADGFDLE ILDGTRGTVD GPGNELSRLS KKNIFLQFKK LCSFRYRRDL LKLSYGEAKK
AARDYETAKN YFKKSLRDMG YGNWISKPQE EKNFYLCPVP ND
//
