ID A0A1S3F3Q5_DIPOR Unreviewed; 1178 AA.
AC A0A1S3F3Q5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Ras-specific guanine nucleotide-releasing factor 2 {ECO:0000313|RefSeq:XP_012871266.1};
GN Name=Rasgrf2 {ECO:0000313|RefSeq:XP_012871266.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012871266.1};
RN [1] {ECO:0000313|RefSeq:XP_012871266.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012871266.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_012871266.1; XM_013015812.1.
DR AlphaFoldDB; A0A1S3F3Q5; -.
DR STRING; 10020.ENSDORP00000001276; -.
DR GeneID; 105985315; -.
DR KEGG; dord:105985315; -.
DR CTD; 5924; -.
DR InParanoid; A0A1S3F3Q5; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd13261; PH_RasGRF1_2; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF187; RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR 2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671}.
FT DOMAIN 22..133
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 243..326
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 408..526
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 573..694
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 943..1175
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 648..684
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 697..749
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 765..805
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 161..188
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 668..684
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 697..711
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1178 AA; 133606 MW; 4EEA8C132A80A676 CRC64;
MQKSVRYNEG HALYLAFLAR KEGTKRGFLS KKAAEASRWH EKWFALYQNV LFYFEGEQSG
RPAGMYLLEG CSCERTPAPP RTGAGPGGGR DALDKQYYFT VLFGHEGQKP LELRCEEEQD
GKEWMEAIHQ ASYADILIER EVLMQKYIHL VQIVETEKIA ANQLRHQLED QDTEIERLKS
EIVALNKTKE RMRPYQSNQE DEDPDIKKIK KVQSFMRGWL CRRKWKTIVQ DYICSPHAES
MRKRNQIVFT MVEAESEYVH QLYILVNGFL RPLRMAASSK KPPISHDDVS SIFLNSETIM
FLHEIFHQGL KARIANWPTL ILGKCIPRYI ITLHELLAHT PHEHVERKSL EFAKSKLEEL
SRVMHDEVSD TENIRKNLAI ERMIVEGCDI LLDTSQTFIR QGSLIQVPSV ERGKLSKVRL
GSLSLKKEGE RQCFLFTKHF LICTRSSGGK LHLLKTGGVL SLIECTLIEE PDASDDDSKG
SGHMFGHLDF KIVVEPPDAT PFTVVLLAPS RQEKAAWMSD ISQCVDNIRC NGLMTIVFEE
NSKVTVPHMI KSDARLHKDD TDICFSKTLN SCKVPQIRYA SVERLLERLT DLRFLSIDFL
NTFLHTYRIF TTAAVVLAKL SDIYKRPFTS IPVRSLELFF ATSQNNRGEH LVDGKSPRLC
RKFSSPPPLA VSRTSSPVRA RKLSLTSPLN SRIGALDLTT SSSSSSPTTT HSPAASPPPH
TGKVPLDLSR GLSSPEQSPG SVEENVDNPR VDLCNKLKRS IQRATVLESA PSDRAGVEGS
PATEATEHSP CRSPSTPRHL RYRQPGGQVA DNAHCSVSPA SAFAIATAAA GHGSPPGFNN
TERTCDKEFI IRRTATNRVL NVLRHWVSKH AQDFELNNEL KMNVLNLLEE VLRDPDLLPQ
ERKATANILR ALSQDDQDDI HLKLEDIIQM TDCPKAECFE TLSAMEMAEQ ITLLDHIVFR
SIPYEEFLGQ GWMKLDKNER TPYIMKTSQH FNDMSNLVAS QIMNYADVSS RANAIEKWVA
VADICRCLHN YNGVLEITSA LNRSAIYRLK KTWAKVSKQT KALMDKLQKT VSSEGRFKNL
RETLKNCNPP AVPYLGMYLT DLAFIEEGTP NFTEEGLVNF SKMRMISHII REIRQFQQTS
YRIDHQPKVT QYLLDKALII DEDTLYELSL KIEPRLPA
//
