ID A0A1S3F4Y0_DIPOR Unreviewed; 685 AA.
AC A0A1S3F4Y0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Neuroligin-1 isoform X7 {ECO:0000313|RefSeq:XP_012871636.1};
GN Name=Nlgn1 {ECO:0000313|RefSeq:XP_012871636.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012871636.1};
RN [1] {ECO:0000313|RefSeq:XP_012871636.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012871636.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC {ECO:0000256|ARBA:ARBA00005964}.
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DR RefSeq; XP_012871636.1; XM_013016182.1.
DR AlphaFoldDB; A0A1S3F4Y0; -.
DR ESTHER; dipor-a0a1s3f5v6; Neuroligin.
DR GeneID; 105985585; -.
DR CTD; 22871; -.
DR OrthoDB; 4386at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042043; F:neurexin family protein binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0071709; P:membrane assembly; IEA:UniProt.
DR GO; GO:0051240; P:positive regulation of multicellular organismal process; IEA:UniProt.
DR GO; GO:0032879; P:regulation of localization; IEA:UniProt.
DR GO; GO:0042391; P:regulation of membrane potential; IEA:UniProt.
DR GO; GO:0031644; P:regulation of nervous system process; IEA:UniProt.
DR GO; GO:0007416; P:synapse assembly; IEA:UniProt.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002018; CarbesteraseB.
DR InterPro; IPR019819; Carboxylesterase_B_CS.
DR InterPro; IPR000460; Nlgn.
DR PANTHER; PTHR43903; NEUROLIGIN; 1.
DR PANTHER; PTHR43903:SF2; NEUROLIGIN-1; 1.
DR Pfam; PF00135; COesterase; 1.
DR PRINTS; PR01090; NEUROLIGIN.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR PROSITE; PS00941; CARBOXYLESTERASE_B_2; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 538..561
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 18..468
FT /note="Carboxylesterase type B"
FT /evidence="ECO:0000259|Pfam:PF00135"
FT REGION 489..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 664..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 685 AA; 76817 MW; AB8B9EC62254DAB4 CRC64;
MLPVWFTNNL DVVSSYVQDQ SEDCLYLNIY VPTEDDIRDS GGPKPVMVYI HGGSYMEGTG
NLYDGSVLAS YGNVIVITVN YRLGVLGFLS TGDQAAKGNY GILDLIQALR WTSENIGFFG
GDPLRITVFG SGAGGSCVNL LTLSHYSEGL FQRAIAQSGT ALSSWAVSFQ PAKYARMLAT
KVGCNVSDTV ELVECLQKKP YKELIDQDIQ PARYHIAFGP VIDGDVIPDD PQILMEQGEF
LNYDIMLGVN QGEGLKFVEN IVDSDDGISA SDFDFAVSNF VDNLYGYPEG KDVLRETIKF
MYTDWADRHN PETRRKTLLA LFTDHQWVAP AVATADLHSN FGSPTYFYAF YHHCQTDQVP
AWADAAHGDE VPYVLGIPMI GPTELFPCNF SKNDVMLSAV VMTYWTNFAK TGDPNQPVPQ
DTKFIHTKPN RFEEVAWTRY SQKDQLYLHI GLKPRVKEHY RANKVNLWLE LVPHLHNLND
ISQYTSTTTK VPSTDITLRP TRKNSIPVTS AFPTTKQDDP KQQPSPFSVD QRDYSTELSV
TIAVGASLLF LNILAFAALY YKKDKRRHDV HRRCSPQRTT TNDLTHAQEE EIMSLQMKHT
DLDHECESIH PHEVVLRTAC PPDYTLAMRR SPDDVPLMTP NTITMIPNTI PGIQPLHTFN
TFTGGQNNTL PHPHPHPHSH STTRV
//
