ID A0A1S3F5G4_DIPOR Unreviewed; 320 AA.
AC A0A1S3F5G4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Arf-GAP with dual PH domain-containing protein 2 isoform X4 {ECO:0000313|RefSeq:XP_012871836.1};
GN Name=Adap2 {ECO:0000313|RefSeq:XP_012871836.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012871836.1};
RN [1] {ECO:0000313|RefSeq:XP_012871836.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012871836.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_012871836.1; XM_013016382.1.
DR AlphaFoldDB; A0A1S3F5G4; -.
DR GeneID; 105985742; -.
DR CTD; 55803; -.
DR OrthoDB; 1022106at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:1902936; F:phosphatidylinositol bisphosphate binding; IEA:InterPro.
DR CDD; cd13252; PH1_ADAP; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR037849; PH1_ADAP.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46021; ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN; 1.
DR PANTHER; PTHR46021:SF6; ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 9..136
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 132..233
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 255..320
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 320 AA; 37186 MW; D792429B4F00F848 CRC64;
MGDRERNKKR LLELLQAAGT GNAYCADCGA ADPDWASYKL GIFICLHCSG VHRNFPDVSK
VKSVRLDFWD DSIVEFMTHN GNLRVKAKFE ARVPAFYYIP QANDCLVLKE QWIRAKYERQ
EFMADGKTVS SSGNREGILW KRGRDNAQFL RRRFVLLARE GLLKYYTKEE SKGPKAVISI
KDLNATFQTE KIGHPHGLQI TYKREGRNRN LFVYHESGKE IVDWFNALRA ARLQYLKVAF
PEQPEAELVP FITRNYLKQG FMEKTGPKQR EPFKKRWFAL DPQERRLLYY KNPLLHQQTV
AAGDLLSQYH CREGGWPLST
//
