ID   A0A1S3F702_DIPOR        Unreviewed;       497 AA.
AC   A0A1S3F702;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Phosphatidylinositol 3-kinase regulatory subunit gamma {ECO:0000313|RefSeq:XP_012872428.1};
GN   Name=Pik3r3 {ECO:0000313|RefSeq:XP_012872428.1};
OS   Dipodomys ordii (Ord's kangaroo rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC   Dipodomyinae; Dipodomys.
OX   NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012872428.1};
RN   [1] {ECO:0000313|RefSeq:XP_012872428.1}
RP   IDENTIFICATION.
RC   TISSUE=Kidney {ECO:0000313|RefSeq:XP_012872428.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the PI3K p85 subunit family.
CC       {ECO:0000256|ARBA:ARBA00009442}.
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DR   RefSeq; XP_012872428.1; XM_013016974.1.
DR   AlphaFoldDB; A0A1S3F702; -.
DR   STRING; 10020.ENSDORP00000016327; -.
DR   GeneID; 105986178; -.
DR   KEGG; dord:105986178; -.
DR   CTD; 8503; -.
DR   InParanoid; A0A1S3F702; -.
DR   OrthoDB; 2880119at2759; -.
DR   Proteomes; UP000081671; Unplaced.
DR   CDD; cd09930; SH2_cSH2_p85_like; 1.
DR   CDD; cd09942; SH2_nSH2_p85_like; 1.
DR   Gene3D; 1.10.287.1490; -; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 2.
DR   InterPro; IPR032498; PI3K_P85_iSH2.
DR   InterPro; IPR035020; PI3kinase_P85_cSH2.
DR   InterPro; IPR035022; PI3kinase_P85_nSH2.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR   PANTHER; PTHR10155:SF10; PI3K21B, ISOFORM B; 1.
DR   Pfam; PF16454; PI3K_P85_iSH2; 1.
DR   Pfam; PF00017; SH2; 2.
DR   PRINTS; PR00678; PI3KINASEP85.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00252; SH2; 2.
DR   SUPFAM; SSF55550; SH2 domain; 2.
DR   PROSITE; PS50001; SH2; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191}.
FT   DOMAIN          101..196
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          394..488
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   COILED          217..244
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   497 AA;  58550 MW;  8357258A59AA3FB9 CRC64;
     MEERSRAERL GEIKVKVKDV LFVVFVDPEN SRTPGAMYNT VWSMDRDDAD WREVMMPYST
     ELIFYIEMDP PALPPKPPKP MTSAVTNGMK DSCVALQDAE WYWGDISREE VNDKLRDMPD
     GTFLVRDAST KMQGDYTLTL RKGGNNKLIK IYHRDGKYGF SDPLTFNSVV ELINHYHHES
     LAQYNPKLDV KLMYPVSRYQ QDQLVKEDNI DAVGKKLQEY HSQYQEKSKE YDRLYEEYTR
     TSQEIQMKRT AIEAFNETIK IFEEQCHTQE QYSKEYIERF RREGNEKEIE RIMMNFDKLK
     SRLGEIHDSK MRLEQDLKKQ ALDNREIDKK MNSIKPDLIQ LRKIRDQHLV WLNHKGVRQK
     RLNTWLGIKN EDVDESYYIN EEEENLPHYD EKTWFVEDIN RVQAEDLLCG KPDGSFLIRE
     SSKKGCYACS VVADGEVKHC VIYSTARGYG FAEPYNLYSS LKELVLHYQQ TSLVQHNDSL
     NVRLAYPVHA QMPSLCR
//