ID A0A1S3F905_DIPOR Unreviewed; 178 AA.
AC A0A1S3F905;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Endothelin-2 {ECO:0000256|ARBA:ARBA00017756};
DE AltName: Full=Preproendothelin-2 {ECO:0000256|ARBA:ARBA00031940};
GN Name=Edn2 {ECO:0000313|RefSeq:XP_012872327.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012872327.1};
RN [1] {ECO:0000313|RefSeq:XP_012872327.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012872327.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the endothelin/sarafotoxin family.
CC {ECO:0000256|ARBA:ARBA00010959}.
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DR RefSeq; XP_012872327.1; XM_013016873.1.
DR AlphaFoldDB; A0A1S3F905; -.
DR STRING; 10020.ENSDORP00000005684; -.
DR GeneID; 105986113; -.
DR KEGG; dord:105986113; -.
DR CTD; 1907; -.
DR InParanoid; A0A1S3F905; -.
DR OMA; PTAWCSV; -.
DR OrthoDB; 4317037at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0031708; F:endothelin B receptor binding; IEA:Ensembl.
DR GO; GO:0005179; F:hormone activity; IEA:Ensembl.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:0014824; P:artery smooth muscle contraction; IEA:Ensembl.
DR GO; GO:0048675; P:axon extension; IEA:Ensembl.
DR GO; GO:0009932; P:cell tip growth; IEA:Ensembl.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0043542; P:endothelial cell migration; IEA:Ensembl.
DR GO; GO:0097009; P:energy homeostasis; IEA:Ensembl.
DR GO; GO:0048286; P:lung alveolus development; IEA:Ensembl.
DR GO; GO:0042116; P:macrophage activation; IEA:Ensembl.
DR GO; GO:0048246; P:macrophage chemotaxis; IEA:Ensembl.
DR GO; GO:0030593; P:neutrophil chemotaxis; IEA:Ensembl.
DR GO; GO:0050850; P:positive regulation of calcium-mediated signaling; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0010460; P:positive regulation of heart rate; IEA:Ensembl.
DR GO; GO:0002690; P:positive regulation of leukocyte chemotaxis; IEA:Ensembl.
DR GO; GO:0045987; P:positive regulation of smooth muscle contraction; IEA:Ensembl.
DR GO; GO:0001516; P:prostaglandin biosynthetic process; IEA:Ensembl.
DR GO; GO:0003100; P:regulation of systemic arterial blood pressure by endothelin; IEA:Ensembl.
DR GO; GO:0019229; P:regulation of vasoconstriction; IEA:InterPro.
DR GO; GO:0001659; P:temperature homeostasis; IEA:Ensembl.
DR GO; GO:0014826; P:vein smooth muscle contraction; IEA:Ensembl.
DR InterPro; IPR020475; Endothelin.
DR InterPro; IPR019764; Endothelin_toxin_CS.
DR InterPro; IPR001928; Endothln-like_toxin.
DR PANTHER; PTHR13874; ENDOTHELIN; 1.
DR PANTHER; PTHR13874:SF9; ENDOTHELIN-2; 1.
DR Pfam; PF00322; Endothelin; 1.
DR PRINTS; PR00365; ENDOTHELIN.
DR SMART; SM00272; END; 2.
DR PROSITE; PS00270; ENDOTHELIN; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Vasoactive {ECO:0000256|ARBA:ARBA00022858};
KW Vasoconstrictor {ECO:0000256|ARBA:ARBA00023322}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..178
FT /note="Endothelin-2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010208117"
FT DOMAIN 48..69
FT /note="Endothelin-like toxin"
FT /evidence="ECO:0000259|SMART:SM00272"
FT DOMAIN 95..116
FT /note="Endothelin-like toxin"
FT /evidence="ECO:0000259|SMART:SM00272"
SQ SEQUENCE 178 AA; 19931 MW; 23B2A348E45DBE5A CRC64;
MVSTPTAWYS VALALLVALH EGKGQAADNP EPPELAAQTR GAHLRSRRCS CSSWLDKECV
YFCHLDIIWV NTAGQTAPYG LGNPPRRRRR SLPRRCECSS TRDPVCATFC HRSPWTEAVS
VPRSQSLAQV PQTGKTWASA GELLQSLRDI SASKVHLAQQ QQQMMTKPRP AHSRWRKR
//
