ID A0A1S3F9M6_DIPOR Unreviewed; 631 AA.
AC A0A1S3F9M6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Exonuclease 3'-5' domain-containing protein 2 isoform X2 {ECO:0000313|RefSeq:XP_012872970.1};
GN Name=Exd2 {ECO:0000313|RefSeq:XP_012872970.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012872970.1};
RN [1] {ECO:0000313|RefSeq:XP_012872970.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012872970.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_012872970.1; XM_013017516.1.
DR AlphaFoldDB; A0A1S3F9M6; -.
DR STRING; 10020.ENSDORP00000014200; -.
DR GeneID; 105986534; -.
DR CTD; 55218; -.
DR OMA; TPKENQC; -.
DR OrthoDB; 8362at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0045111; C:intermediate filament cytoskeleton; IEA:Ensembl.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:Ensembl.
DR GO; GO:0090734; C:site of DNA damage; IEA:Ensembl.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:Ensembl.
DR GO; GO:0000287; F:magnesium ion binding; IEA:Ensembl.
DR GO; GO:0030145; F:manganese ion binding; IEA:Ensembl.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0008310; F:single-stranded DNA 3'-5' DNA exonuclease activity; IEA:Ensembl.
DR GO; GO:0000729; P:DNA double-strand break processing; IEA:Ensembl.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:Ensembl.
DR GO; GO:0031297; P:replication fork processing; IEA:Ensembl.
DR CDD; cd06141; WRN_exo; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR13620; 3-5 EXONUCLEASE; 1.
DR PANTHER; PTHR13620:SF104; EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 4: Predicted;
KW Exonuclease {ECO:0000313|RefSeq:XP_012872970.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 89..272
FT /note="3'-5' exonuclease"
FT /evidence="ECO:0000259|SMART:SM00474"
FT REGION 34..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 316..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..342
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 631 AA; 71268 MW; 5A463D10D9E2FD61 CRC64;
MSRQNLVALT ATTLLGIAVG GFVLWKGLQR RRSKVNPVAQ PQPQPQPQPQ PHPVAGGSEH
SPPRENQLSP GVQRPSRASW EEKILQAKVV TVSQEAEWDQ VEPLLRSELE DFPVLGFDCE
WVNLEGKANP LSLLQMASPS GLCVLVRLPK LICGGKPLPR TLLDLLADST ILKVGVGCSE
DASKLLQDYG LMARGCLDLR YLAIRQGNNF LCNGLSLKSL AETILNFPLD KSLLLRCSNW
DAESLTEEQV TYAARDAQIS VALFLHLLGY PFSKNSPVEG NSDCISWKNV LEKCQNMVDV
PFRSKAFSRL GEEVNGETTE FQQKPRNKKC KTDEMVPGNH QGRDPRKHKR KPLGVGYSAR
KSPLYDNCFL HAPDGQPLCT CDRRKAQWYL DKGIGELVSE DPFVVRLQFE PAGRPESPGD
YYLMVKENLC VVCGKTDSYI RKNVIPHEYR KHFPIDMKDH NSHDVLLLCT SCHAISNYYD
NHLKQQLAKE FQAPIGSEEG LRLLEDSERR QVRSGARALL NAESLPAHRK EELLQALREF
YSTDTITDEM LQEAASLETR ISNENYVPHG LKVVQRHSQG GLRSLMQLES RWRQHFLDSM
QPKHLPQQWS VDHNHQKLLR KYGEDLPIKL S
//