UniProt: A0A1S3FAY8

Database: UniProt
Entry: A0A1S3FAY8_DIPOR

LinkDB:  A0A1S3FAY8_DIPOR 
Original site:  A0A1S3FAY8_DIPOR

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Ontology (5)   
   GO (5)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (5)   
   RefSeq(pep) (5)   
Protein domain (3)   
   InterPro (1)   
   Pfam (1)   
   PROSITE (1)   
All databases (16)   

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ID   A0A1S3FAY8_DIPOR        Unreviewed;       377 AA.
AC   A0A1S3FAY8;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=Palmitoyltransferase {ECO:0000256|RuleBase:RU079119};
DE            EC=2.3.1.225 {ECO:0000256|RuleBase:RU079119};
GN   Name=Zdhhc16 {ECO:0000313|RefSeq:XP_012873194.1,
GN   ECO:0000313|RefSeq:XP_012873195.1, ECO:0000313|RefSeq:XP_012873196.1,
GN   ECO:0000313|RefSeq:XP_012873197.1, ECO:0000313|RefSeq:XP_012873198.1};
OS   Dipodomys ordii (Ord's kangaroo rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC   Dipodomyinae; Dipodomys.
OX   NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012873194.1};
RN   [1] {ECO:0000313|RefSeq:XP_012873194.1, ECO:0000313|RefSeq:XP_012873195.1}
RP   IDENTIFICATION.
RC   TISSUE=Kidney {ECO:0000313|RefSeq:XP_012873194.1,
RC   ECO:0000313|RefSeq:XP_012873195.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-
CC         hexadecanoyl-L-cysteinyl-[protein]; Xref=Rhea:RHEA:36683, Rhea:RHEA-
CC         COMP:10131, Rhea:RHEA-COMP:11032, ChEBI:CHEBI:29950,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:57379, ChEBI:CHEBI:74151;
CC         EC=2.3.1.225; Evidence={ECO:0000256|RuleBase:RU079119};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- DOMAIN: The DHHC domain is required for palmitoyltransferase activity.
CC       {ECO:0000256|RuleBase:RU079119}.
CC   -!- SIMILARITY: Belongs to the DHHC palmitoyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00008574, ECO:0000256|RuleBase:RU079119}.
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DR   RefSeq; XP_012873194.1; XM_013017740.1.
DR   RefSeq; XP_012873195.1; XM_013017741.1.
DR   RefSeq; XP_012873196.1; XM_013017742.1.
DR   RefSeq; XP_012873197.1; XM_013017743.1.
DR   RefSeq; XP_012873198.1; XM_013017744.1.
DR   STRING; 10020.ENSDORP00000015553; -.
DR   GeneID; 105986702; -.
DR   KEGG; dord:105986702; -.
DR   CTD; 84287; -.
DR   OMA; DGIVWDC; -.
DR   OrthoDB; 6683at2759; -.
DR   Proteomes; UP000081671; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0019706; F:protein-cysteine S-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006974; P:DNA damage response; IEA:Ensembl.
DR   GO; GO:0001654; P:eye development; IEA:Ensembl.
DR   GO; GO:0007507; P:heart development; IEA:Ensembl.
DR   InterPro; IPR001594; Palmitoyltrfase_DHHC.
DR   PANTHER; PTHR12246; PALMITOYLTRANSFERASE ZDHHC16; 1.
DR   PANTHER; PTHR12246:SF13; PALMITOYLTRANSFERASE ZDHHC16; 1.
DR   Pfam; PF01529; DHHC; 1.
DR   PROSITE; PS50216; DHHC; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU079119};
KW   Membrane {ECO:0000256|RuleBase:RU079119};
KW   Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW   Transferase {ECO:0000256|RuleBase:RU079119};
KW   Transmembrane {ECO:0000256|RuleBase:RU079119};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU079119}.
FT   TRANSMEM        75..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        115..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        199..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   TRANSMEM        267..290
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU079119"
FT   DOMAIN          155..302
FT                   /note="Palmitoyltransferase DHHC"
FT                   /evidence="ECO:0000259|Pfam:PF01529"
SQ   SEQUENCE   377 AA;  43664 MW;  2909B37C5984A101 CRC64;
     MRVQRSLLLG PARLCLRILL LLGYRRRCPP LLRGLVQRWR YGKVCLRSLL YNSFGGSDTA
     VDAAFEPVYW LVDNVIRWFG VVFVVLVIVL TGSIVAIAYL CVLPLILQTY SVPRLCWHFF
     YSHWNLILIV FHYYQAITTP PGYPPQGRND IATVSICKKC IYPKPARTHH CSICNRCVLK
     MDHHCPWLNN CVGHYNHRYF FSFCFFMTLG CVYCSYGSWD LFREAYAAIE KMKQLDKNKL
     QAVGNQTYHQ TPPPIFSFRE RITHKSLVYL WFLCSSVALA LGALTVWHAI LISRGETSIE
     RHINKKERRR LQAKGRVFRN PYNYGCLDNW KIFLGVDTGR HWLTRVLLPS NHLPHGNGLS
     WEPPPWVTAH SASVMAV
//

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