ID A0A1S3FCV2_DIPOR Unreviewed; 951 AA.
AC A0A1S3FCV2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Oncostatin-M-specific receptor subunit beta isoform X2 {ECO:0000313|RefSeq:XP_012874090.1};
GN Name=Osmr {ECO:0000313|RefSeq:XP_012874090.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012874090.1};
RN [1] {ECO:0000313|RefSeq:XP_012874090.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012874090.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 2
CC subfamily. {ECO:0000256|ARBA:ARBA00008921}.
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DR RefSeq; XP_012874090.1; XM_013018636.1.
DR AlphaFoldDB; A0A1S3FCV2; -.
DR GeneID; 105987384; -.
DR CTD; 9180; -.
DR OrthoDB; 5347052at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003529; Hematopoietin_rcpt_Gp130_CS.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR040817; LIFR_D2.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF95; ONCOSTATIN-M-SPECIFIC RECEPTOR SUBUNIT BETA; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF17971; LIFR_D2; 1.
DR SMART; SM00060; FN3; 4.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR PROSITE; PS50853; FN3; 2.
DR PROSITE; PS01353; HEMATOPO_REC_L_F2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_012874090.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 713..733
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 307..400
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 597..708
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 951 AA; 107390 MW; 90598B098A29F7F7 CRC64;
MDKLSPLTPV SPRISFKSSL QHLDLEWTVQ NLPHHQELKM IFLIEISRIR TSNIIWVGNY
STTVKWNQVI HWSWKSELPL ECATHFVRIK SMVDNGMPPE LSSWSEWSSW EEVHAQNPLE
PNALFVFPKR KLVEEGANVT ICSIFGSNLK DIFCYLEGEL IHGEQLDSHI LTFELSNVPF
VRVSGMNFYC VEKPTNITDG IVLFVSKVLE EPKDFSCETR DFKTLSCTWS PGVDTGLGWS
MQPSQSYTLV ESVSRERKHC EHKNVCNWKI TQELQEIYNF TLIAENHLRK RSVNIFFNLT
HRVHPLAPYN VSLESIEATQ ATLRWKVLYH GNRYSLLCQV ELEGEGKVIQ SNVSVKVSGE
EIFSELVPDT EYQACIRCAG AGHFWKWSEW NCQKFSTSEA APSEALAVWS TVREENGSCI
VNLFWKPLSK LHAKGKILHY NIITENLDKP HRVKLYSASG LANDMKLTLD QCAYQINVTA
SNSAGQSPAS VIAISGDSGK EVEEERIQRT EDGFFVSWKP LSADNIIGYV VGWCVRLQDP
LCDLQWKNIG PNTTSTVISS DAFRPGIRYD FRVYGISTGR VASLIEKRTG YYRELTPSMN
PRVTVKNLTS HSFVLSWTDY STNDQSGFIQ GYHVSLKSKN RQCQPGFEKA VCSDDSVCCK
YNIKNPEQKT FTVENLQPES HYEFLVTSYT RVGEGPNGTF TAVTTPDELS YTLVQIILPM
IFSVLLIISV CYWKSQWVKE KCYPEIPDPN KSSILSLIKS KENPHLTIMN VKDCIPDALE
VINKPESTKA QVMGTEKPFL AESELTAYLY PLQKEHSGPG PWICFENFTY NQSASDAGLC
GHIPVPSKDL PWQQGLLTQP DNLLNVLEGN CEQPLREIPA GEASLNYVSQ LASPLYGDKD
SFSNNPTTTM PEPCSDYKMQ MAVPACLASP LPSKESSLSS VVLLDQGEHY H
//
