ID A0A1S3FES2_DIPOR Unreviewed; 535 AA.
AC A0A1S3FES2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Suppressor of cytokine signaling 6 {ECO:0000313|RefSeq:XP_012874462.1};
GN Name=Socs6 {ECO:0000313|RefSeq:XP_012874462.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012874462.1};
RN [1] {ECO:0000313|RefSeq:XP_012874462.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012874462.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_012874462.1; XM_013019008.1.
DR AlphaFoldDB; A0A1S3FES2; -.
DR STRING; 10020.ENSDORP00000011322; -.
DR GeneID; 105987664; -.
DR KEGG; dord:105987664; -.
DR CTD; 9306; -.
DR InParanoid; A0A1S3FES2; -.
DR OMA; TPWPLRS; -.
DR OrthoDB; 5401079at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0040008; P:regulation of growth; IEA:InterPro.
DR CDD; cd10387; SH2_SOCS6; 1.
DR CDD; cd03740; SOCS_SOCS6; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.10.750.20; SOCS box; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035865; SOCS6_SH2.
DR InterPro; IPR037345; SOCS6_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF28; SUPPRESSOR OF CYTOKINE SIGNALING 6; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 384..491
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 486..535
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 55..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 243..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..73
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 98..112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 535 AA; 59513 MW; 8E83714CDFEFC0F6 CRC64;
MKKISLKTFR KSFNLNKSKE ETDFMVVQPP SLASDFGKED SLFGGCYGKD MASCDLNDEE
KGGKPRSKSE SLMGTLKRRL SVKQKPKGKG STPPGGGSAD DDTFSSSSAP IVFKDVRAQR
PIRSTSLRSH HYSPTPWPLR PTNSEETCIK MEVRVKALVH SSSPSPSLNG VRKDFHDLQS
ETVCQEPSIP LKSSDSPTGD LRLHLDDHVP VVIGLMPQDY IQYTVPLDDG MYPLEGSRSY
CLDSSSPMEV SAIPPQEGGS SFPEEENQVD QDLVVGPEIF VDQSVNGLLI GTTGVMLQSP
RASHDDVPPL SPLLPPMQNS QIQRNFSGLT GPDAHVAESM RCHLNFDPNS APGVARVYDS
VQSSGPMAVT SLTEELKKLA KQGWYWGPIT RWEAEGKLAN VPDGSFLVRD SSDDRYLLSL
SFRSHGKTLH TRIEHSNGRF SFYEQPDVEG HTSIVDLIEH SIRDSENGAF CYSRSRLPGS
ATYPVRLTNP VSRFMQVRSL QYLCRFVIRQ YTRIDLIQKL PLPNKMKDYL QEKHY
//
