ID A0A1S3FEV9_DIPOR Unreviewed; 908 AA.
AC A0A1S3FEV9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Probable G-protein coupled receptor 110 {ECO:0000313|RefSeq:XP_012874579.1};
GN Name=Adgrf1 {ECO:0000313|RefSeq:XP_012874579.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012874579.1};
RN [1] {ECO:0000313|RefSeq:XP_012874579.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012874579.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_012874579.1; XM_013019125.1.
DR AlphaFoldDB; A0A1S3FEV9; -.
DR STRING; 10020.ENSDORP00000002406; -.
DR GeneID; 105987767; -.
DR KEGG; dord:105987767; -.
DR CTD; 266977; -.
DR InParanoid; A0A1S3FEV9; -.
DR OrthoDB; 3876300at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 3.30.70.960; SEA domain; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR008078; GPCR_2_Ig-hepta-like_rcpt.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000082; SEA_dom.
DR InterPro; IPR036364; SEA_dom_sf.
DR PANTHER; PTHR45813:SF3; ADHESION G-PROTEIN COUPLED RECEPTOR F1; 1.
DR PANTHER; PTHR45813; EF-HAND DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF01390; SEA; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01695; IGHEPTARCPTR.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF82671; SEA domain; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50024; SEA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_012874579.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..908
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010359964"
FT TRANSMEM 582..604
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 625..651
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 657..682
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 694..719
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 742..764
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 784..804
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 816..838
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 146..254
FT /note="SEA"
FT /evidence="ECO:0000259|PROSITE:PS50024"
FT DOMAIN 583..840
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 908 AA; 100481 MW; A68341B4BBCC4B15 CRC64;
MRAGVLWLIP FFTLVDTQRG ILGRNGGMKS NGAHGADKRK PAGGEYELLL QMTYRDSKEK
RDLESFLKLL KSPSPCLHEP TKIIRVKATT YCSRQSRVLR CLCEDGYTWF PPSCLDPQHC
RLRRTGPLPS CECPRNSLGH SVNFCERAKV WGTFKINKRF TEDLWNSSST VYTNYKNRIE
SQLKEVYEGI PGFDSIHVTQ FREGSIVVGY EVIGSRSTSE LLSSLAQMAD KAKASLGKLF
PLEDGSFRIF GKAPCNSVFF GFGSEDDEYV LPCTSGYTGT VTARCLSAGW QVSRESCVLS
QLKELQKNFS VIAGNATEED ISSLVQNLSV IIQKSPSTTA GNLASVVSIL GNISSLSLAN
HLKVSNLTLK NIINIADHIL NLASITNWTV LLQDDKQASS QLLETLENIS ILVPSTALPL
SFSREFIDWK GIPMTPSRDP RGYSYQVQLM QPNASVPTTG HVLIRADQFQ KSLPEAIISM
ASLTFGAILP ITPKDVAQVN GPVLSTLIPN YSIHEIFLRF SKMKPHLQQP RCVFWDFGRL
QWDSAGCHLV NETPEAVLCR CTHLTSFSIL MSPYVPPGVT SALTWITHVG LGVSIASLIL
CLLLEALCWK QTRRNPTSFS RHVCLVNIAL SLLAADVWFI VAATLDAALV FSSLCSAAVF
FTHLFYLSLF FWMLALALLL AYRLALVFHH VAMSLMMAIG FGLGYGCPLL IAIVTIAAIP
PGHGYQRTDV CWLNWSHRSK PLLAFVVPAL MIVVVNSAVV LLVLRKLWRP AVGERLNRDD
RATVIRMGKS LLILAPLLGL TWGFGVGTMV DSHNVVWHVL FALFNAFQGF FILCFGILSD
SKLRQLLCNK LPPLSSWKQT SKQNTSDPSS KPKCLKPFHL LQNKGNYTLS HTGSSSTSIT
LTQFLSNE
//
