ID A0A1S3FEX0_DIPOR Unreviewed; 243 AA.
AC A0A1S3FEX0;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Calcipressin-2 {ECO:0000256|ARBA:ARBA00015789};
DE AltName: Full=Regulator of calcineurin 2 {ECO:0000256|ARBA:ARBA00029914};
GN Name=Rcan2 {ECO:0000313|RefSeq:XP_012874507.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012874507.1};
RN [1] {ECO:0000313|RefSeq:XP_012874507.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012874507.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Inhibits calcineurin-dependent transcriptional responses by
CC binding to the catalytic domain of calcineurin A. Could play a role
CC during central nervous system development.
CC {ECO:0000256|ARBA:ARBA00024927}.
CC -!- SIMILARITY: Belongs to the RCAN family.
CC {ECO:0000256|ARBA:ARBA00008209}.
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DR RefSeq; XP_012874507.1; XM_013019053.1.
DR AlphaFoldDB; A0A1S3FEX0; -.
DR STRING; 10020.ENSDORP00000002389; -.
DR GeneID; 105987692; -.
DR KEGG; dord:105987692; -.
DR CTD; 10231; -.
DR InParanoid; A0A1S3FEX0; -.
DR OrthoDB; 2727072at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0019722; P:calcium-mediated signaling; IEA:InterPro.
DR CDD; cd12709; RRM_RCAN2; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR006931; Calcipressin.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034919; RCAN2_RRM.
DR PANTHER; PTHR10300; CALCIPRESSIN; 1.
DR PANTHER; PTHR10300:SF5; CALCIPRESSIN-2; 1.
DR Pfam; PF04847; Calcipressin; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000081671}.
FT REGION 211..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..227
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 243 AA; 27182 MW; 274421B9BE26F869 CRC64;
MRGESFFIGM RSPGQQGYTP EDGGLLLLCC IDRDWAVTRC FAEEAFQAIT DFNDLPNALF
ACNVHQSVFE GEESKEKFEG LFRTYDDCVT FQLFKSFRRV RINFSNPKSA ARARIELHET
QFRGKKLKLY FAQVQAPEAD GDKLHLAPPQ PAKQFLISPP SSPPVGWQPI SDATPVLNYD
LLYAVAKLGP GEKYELHAGT ESTPSVVVHV CDSDMEEEED PKTSPKPKII QTRRPGLPPS
VSN
//
