ID A0A1S3FFN4_DIPOR Unreviewed; 153 AA.
AC A0A1S3FFN4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Myelin and lymphocyte protein {ECO:0000256|ARBA:ARBA00039981};
GN Name=Mal {ECO:0000313|RefSeq:XP_012875306.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012875306.1};
RN [1] {ECO:0000313|RefSeq:XP_012875306.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012875306.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MAL family. {ECO:0000256|ARBA:ARBA00034721}.
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DR RefSeq; XP_012875306.1; XM_013019852.1.
DR AlphaFoldDB; A0A1S3FFN4; -.
DR STRING; 10020.ENSDORP00000004713; -.
DR GeneID; 105988282; -.
DR KEGG; dord:105988282; -.
DR CTD; 4118; -.
DR InParanoid; A0A1S3FFN4; -.
DR OMA; FPDIFFI; -.
DR OrthoDB; 4214465at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0120003; C:hinge region between urothelial plaques of apical plasma membrane; IEA:Ensembl.
DR GO; GO:0044853; C:plasma membrane raft; IEA:Ensembl.
DR GO; GO:0019911; F:structural constituent of myelin sheath; IEA:Ensembl.
DR GO; GO:0022010; P:central nervous system myelination; IEA:Ensembl.
DR GO; GO:1902043; P:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
DR GO; GO:0098737; P:protein insertion into plasma membrane; IEA:Ensembl.
DR GO; GO:0002175; P:protein localization to paranode region of axon; IEA:Ensembl.
DR InterPro; IPR013295; MAL.
DR InterPro; IPR008253; Marvel.
DR PANTHER; PTHR22776; MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR22776:SF12; MYELIN AND LYMPHOCYTE PROTEIN; 1.
DR Pfam; PF01284; MARVEL; 1.
DR PRINTS; PR01884; MALPROTEIN.
DR PROSITE; PS51225; MARVEL; 1.
PE 3: Inferred from homology;
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|PROSITE-ProRule:PRU00581, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Transmembrane {ECO:0000256|PROSITE-ProRule:PRU00581,
KW ECO:0000256|SAM:Phobius}; Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 25..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 53..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 18..151
FT /note="MARVEL"
FT /evidence="ECO:0000259|PROSITE:PS51225"
SQ SEQUENCE 153 AA; 16519 MW; 17E9F7F5DAF93C38 CRC64;
MAPAAASGGS TLPSGFSVFA TFPDLLFVLE FIFGGLVWIL IASSLVPIPL VQGWVMFVSV
FCFVATTSLL VLYIIGAHGG ETSWVTLDAA YQCVAAMFYL SASVLEALAT ISMQDGFTFK
HYHENISAVV FSYVATLLYV VHAVFSLIRW KSS
//
