ID   A0A1S3FFR7_DIPOR        Unreviewed;       833 AA.
AC   A0A1S3FFR7;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Prominin-2 isoform X1 {ECO:0000313|RefSeq:XP_012875341.1};
GN   Name=Prom2 {ECO:0000313|RefSeq:XP_012875341.1};
OS   Dipodomys ordii (Ord's kangaroo rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC   Dipodomyinae; Dipodomys.
OX   NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012875341.1};
RN   [1] {ECO:0000313|RefSeq:XP_012875341.1}
RP   IDENTIFICATION.
RC   TISSUE=Kidney {ECO:0000313|RefSeq:XP_012875341.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell projection, microvillus membrane
CC       {ECO:0000256|ARBA:ARBA00004475}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004475}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the prominin family.
CC       {ECO:0000256|ARBA:ARBA00006058}.
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DR   RefSeq; XP_012875341.1; XM_013019887.1.
DR   AlphaFoldDB; A0A1S3FFR7; -.
DR   STRING; 10020.ENSDORP00000015000; -.
DR   GeneID; 105988305; -.
DR   KEGG; dord:105988305; -.
DR   CTD; 150696; -.
DR   InParanoid; A0A1S3FFR7; -.
DR   OMA; ASTQQCH; -.
DR   OrthoDB; 3538424at2759; -.
DR   Proteomes; UP000081671; Unplaced.
DR   GO; GO:0031528; C:microvillus membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008795; Prominin.
DR   PANTHER; PTHR22730; PROMININ PROM PROTEIN; 1.
DR   PANTHER; PTHR22730:SF6; PROMININ-2; 1.
DR   Pfam; PF05478; Prominin; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..833
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5010259020"
FT   TRANSMEM        103..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        152..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        425..451
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        472..497
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        779..799
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   833 AA;  92432 MW;  20C110D4A6A4CF8B CRC64;
     MRVPGLLVSL LSLELGLALS PPHAAASDCG YLGPAERLTF TPAARTRWLA PLVRAPGPLD
     PLYGTVRRFL SVVQLNPFPT ELVKALLNEP SSVKVDEVVR YEAGYVVCAV IAGLFLLAVP
     ITGLCFCCCR CHRRCGGRVK TEHKAMACER GTLMAFLLLT TFVLLVGMVC AFVTNQRTHE
     QTGPSVQAVP ETLLSLQSLV SDIPEELQTV ADQFSLPQNQ VLEDLDGVGE RLGNLIHSQL
     KSKVYLLLAS VHSLGQALQV SMDHLRALNA TTKELQEGQQ HLEPAVRDHR ERLLALLQDP
     QCQGNCTGTL SQVHALELGA DFSQVPHLDD ALYRLKDVPE TNFSSMVQEE NSTFNNLPLL
     IGLQTANAVK DLKKAVSGQP EGVRMLATGF PDLKATSRWS QTLGELEECS RPYLKDVQRY
     ETYRWIVGCV LCSMVLLVVV CNLLGLSLGT WGLSAREDPS HSEAKGEAGA RFLMLSVGFS
     FLFAGPLILL VFATFLVGGN VQTLVCQSWE RGELYEFVDT PGNLPPSMNL SHLLGLKKNI
     SVLVAYQQCR EGAALWKVLQ LNDSYDLEKH LDISQYATKM QQELKGFNVE IKDLDLLSPE
     ARQDLEALQS SGIEKINYHD FFVQIQKPVV KTDMQQLSQD LERLAQAQGN SMLGQQLQEA
     AQGLRNLYHE KVVPQQNLIA KLNLNARALE SAAPNLQLET TALLGNITVL RGELPVFINH
     IMENASRCFM TRELGYFSQY VAWVREEVTQ RIATCQPLSG ALDNGHVILC DMMADPWNAF
     WFCLGWCTFF LIPSIIFAVK TSKYFRPIRK RLSSTSSEET QLFHIPRVTS LKL
//