ID A0A1S3FH34_DIPOR Unreviewed; 1215 AA.
AC A0A1S3FH34;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Proline-rich basic protein 1 isoform X3 {ECO:0000313|RefSeq:XP_012875811.1};
GN Name=LOC105988687 {ECO:0000313|RefSeq:XP_012875811.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012875811.1};
RN [1] {ECO:0000313|RefSeq:XP_012875811.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012875811.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
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DR RefSeq; XP_012875811.1; XM_013020357.1.
DR AlphaFoldDB; A0A1S3FH34; -.
DR GeneID; 105988687; -.
DR OrthoDB; 911690at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR InterPro; IPR006043; NCS2.
DR PANTHER; PTHR11119:SF21; SOLUTE CARRIER FAMILY 23 MEMBER 1; 1.
DR PANTHER; PTHR11119; XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 811..837
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 849..871
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 950..974
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 980..999
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1020..1043
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1170..1191
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 196..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 348..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 432..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 692..736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 752..796
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..154
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..362
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 449..468
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..536
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..564
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 595..610
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 760..793
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1215 AA; 130083 MW; F925B67FAC543DB7 CRC64;
MLTALAPPAL LGLPGRLPTA PARRQDSSGS SGSYHTAPGS PEPPDVGPDA EGPANWLWVA
PGRGAGAQPL LSVSAQNSRQ QPWAGSSFPR GPGSGPPPPR PQLRMLPSGE MEVIFGARPL
LSHSDAEDDK VPQLPAPAFG SPSLPEPAAL TPPQPRAPDG GSRWATYLEV RPRGPSPEVS
TQFECVEVAL EERAAPVRPR TVPKRQIELR PRPQSPQQVT DTPRPRLLLR TGSLDESLGR
LKAAAGLVQS ALARKLGTEA PAPNFTFRPT GRPEPKTQET SRGSRVVLEE GRSRPSRAQN
SSAPARAPRP WPSLRERAIR RDKPTPGTEP LGPVSSSIFL QTEEKIQEVH NQEPKTRFPG
EAPDRIVTRA PNPPLQSRAL WEDQSRAVRP RSPSPSPPWQ SPNGALRGPL CPSPQNLPQC
GRTVWRVTNP SFPEASSAWG KRNAKGENTV SRRSPSPPTL SPRTQAAARA RSPSPEALSP
WEVPHPDVGE GGGRGRGQSP PASFPWEAPD GPAEARSRSS QETGGPVEQG SSTAFPREAM
NGMAAELASP TPSSPGTPEE IEVQSSPTRE ILDLAFRGSQ PSPEVEALEP PRGHLVNTLD
DHERPEALRS GEAASGRPRV AIPLPRDVRK IVKNTYAPSF PAGSPGSAPP KPPAQPCGEE
GVSAKAQAPP ALGSPAPAHY TSIFLKDFLP VVPHPYESPE QSLHTAPPDA PQPNGLPRRR
AENSTAKPFA RTEIRLPGAL TLGQRLERTP GIQVRGASQA CVPQMRTQED SEGQTQNESP
GSAETSARDP KMTQSMEPKS DMLYKIEDVP PWYLCILLGF QHYLTCFSGT IAVPFLLAEA
LCVGRDQYMV SQLIGTIFTC VGVTTLIQTT LGIRLPLFQA SAFAFLVPAK AILALERWKC
PPEEEIYGNW SLPLNTSHIW HPRIREVQGA IMVSSTVEVV IGLMGLPGAL LSYIGPLTVT
PTVSLIGLSV FQAAGDRAGS HWGISACSIL LIVLFSQYLR NLTFLLPVYR WGKGFTLFRI
QIFKMFPIVL AIMTVWLLCY VLTLTDVLPA DPTAYGFQAR TDARGDIMSI SPWIRIPYPC
QWGLPTVTAA AVLGMFSATL AGIIESIGDY YACARLAGAP PPPVHAINRG IFTEGICCII
AGLLGTGNGS TSSSPNIGVL GITKVGSRRV VQYGAGIMLV LGAIGKFTAL FASLPDPILG
GMFCTLFVVS LHLQA
//
