ID A0A1S3FHB1_DIPOR Unreviewed; 473 AA.
AC A0A1S3FHB1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Ras-GEF domain-containing family member 1B isoform X1 {ECO:0000313|RefSeq:XP_012875695.1};
GN Name=Rasgef1b {ECO:0000313|RefSeq:XP_012875695.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012875695.1};
RN [1] {ECO:0000313|RefSeq:XP_012875695.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012875695.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_012875695.1; XM_013020241.1.
DR AlphaFoldDB; A0A1S3FHB1; -.
DR STRING; 10020.ENSDORP00000021469; -.
DR GeneID; 105988580; -.
DR KEGG; dord:105988580; -.
DR CTD; 153020; -.
DR InParanoid; A0A1S3FHB1; -.
DR OMA; ISQTWEH; -.
DR OrthoDB; 7992at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF197; RAS-GEF DOMAIN-CONTAINING FAMILY MEMBER 1B; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671}.
FT DOMAIN 34..161
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 205..453
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 473 AA; 55342 MW; 1686F2C25529DD9A CRC64;
MPQTPPFSAM FDSSGYNRNL YQSSEDSCGG LYYHDNNLLS GSLEALIQHL VPNVDYYPDR
TYIFTFLLSS RLFMHPYELM AKVCQLCVEH QRLSDPDSDK SQMRKIAPKI LQLLTEWTET
FPYDFRDERM MRNLKDLAHR IASGEEQTYR KNVQQMIQCL IRKLTTLSQY EEVLAKISST
STDRLTVLKT KPQSIQRDII TVCSDPYTLA QQLTHIELER LNYIGPEEFV QAFVQKDPLD
NDKSCYTERK KTRNLEAYVE WFNRLSYLVA TEICMPVKKK HRARMIEYFI DVARECFNIG
NFNSLMAIIS GMNMSPVSRL KKTWAKVKTA KFDVLEHQMD PSSNFYNYRT ALRGAAQRSL
TAHSSREKIV IPFFSLLIKD IYFLNEGCAN RLPNGHVNFE KFWELAKQVS EFMTWKQVEC
PFERDRKILQ YLLTVPVFSE DALYLASYES EGPENHTEKD RWKSLRSSLL GRV
//
