ID A0A1S3FM54_DIPOR Unreviewed; 900 AA.
AC A0A1S3FM54;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Low-density lipoprotein receptor-related protein 8 {ECO:0000313|RefSeq:XP_012877653.1};
GN Name=Lrp8 {ECO:0000313|RefSeq:XP_012877653.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012877653.1};
RN [1] {ECO:0000313|RefSeq:XP_012877653.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012877653.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_012877653.1; XM_013022199.1.
DR AlphaFoldDB; A0A1S3FM54; -.
DR STRING; 10020.ENSDORP00000022053; -.
DR GeneID; 105989929; -.
DR KEGG; dord:105989929; -.
DR CTD; 7804; -.
DR InParanoid; A0A1S3FM54; -.
DR OrthoDB; 3918101at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005041; F:low-density lipoprotein particle receptor activity; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00112; LDLa; 5.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 5.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF3; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 8; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF00057; Ldl_recept_a; 5.
DR Pfam; PF00058; Ldl_recept_b; 5.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 5.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF57424; LDL receptor-like module; 5.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 4.
DR PROSITE; PS50068; LDLRA_2; 5.
DR PROSITE; PS51120; LDLRB; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipoprotein {ECO:0000313|RefSeq:XP_012877653.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_012877653.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 755..778
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 302..341
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 388..434
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 435..477
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 478..521
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 522..566
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..747
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..29
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 661..740
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 60..72
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 67..85
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 79..94
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 99..111
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 106..124
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 161..176
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 184..196
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 191..209
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 203..218
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 232..250
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 306..316
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 900 AA; 99049 MW; AB229C9596480105 CRC64;
MGRPARGALR PCSSSISRRR RRRRIRCLTA KVRSASPGPG SAPPTKRGLE VGARGPAKEC
EVDQFRCRNG RCIPSVWRCD EDDDCSDNSD EDDCPKKTCA DSDFTCDNGH CIPERWKCDG
EEECPDGSDE WKATCTRQVC PAEKLSCGPT SHKCVPASWR CDGEKDCEGG ADEAGCATSA
VGACGGDEFQ CGDGTCVLAI KRCNQEQDCP DGSDEAGCLQ ESTCEGPRRF QCKSGECVDS
GKVCDAQRDC RDWSDELLKE CGLNECLHNN GGCSHICTDL KIGFECTCPA GFRLLDQKTC
GDIDECEDPD ACSQICVNYK GYFKCECHPG YEMDALTKNC KAVAGKSPSL IFTNRHEVRR
IDLVKRDYSR LIPMLKNVVA LDVEVVTNRI YWCDLSYRKI YSAYMDKASD PAEQEVLIDE
QLHSPEGLAV DWVHKHIYWT DSGNKTISVA TVDGGRRCTL FNRDLSEPRA IAVDPLRGFM
YWSDWGYQAK IEKSGLNGVD RQTLVSDNIE WPNGIALDLL NQRLYWVDSK LHQLSSIDFS
GGNRKMLIFS TDFLSHPFGI AVFEDKVFWT DLENEAIFSA NRLNGLEISI LAENLNNPHD
IVIFHELKQP RAADACELSA QPNGGCEYLC LPAPQIFSHS PKYTCACPDT MWLGPDMKRC
YRTPQSTSTT TTTTTTSTPT TTRAVPVTTG APGTSHGPTS QNHSTTTASP AAAGPSSVSG
PRAPSISLST PSPATSNHSQ HYGNEDDKMG STVTAAVIGI IVPIAVIALL CMSGYLIWRN
WKRKNTKSMN FDNPVYRKTT EEEDEDELHI GRTTQIGHVY PAAISSFDRP LWAEPCVGET
RELEDPAPAL KELFVLPGEP RSQLHQLPKN PLSELPVVKC KVAHWCSLVL ALGPVSLMVS
//
