ID A0A1S3FMJ1_DIPOR Unreviewed; 1893 AA.
AC A0A1S3FMJ1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Plexin-A4 isoform X1 {ECO:0000313|RefSeq:XP_012877092.1};
GN Name=Plxna4 {ECO:0000313|RefSeq:XP_012877092.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012877092.1};
RN [1] {ECO:0000313|RefSeq:XP_012877092.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012877092.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_012877092.1; XM_013021638.1.
DR STRING; 10020.ENSDORP00000015812; -.
DR GeneID; 105989539; -.
DR KEGG; dord:105989539; -.
DR CTD; 91584; -.
DR OMA; HESRWLE; -.
DR OrthoDB; 1387371at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0150053; C:cerebellar climbing fiber to Purkinje cell synapse; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:Ensembl.
DR GO; GO:0021960; P:anterior commissure morphogenesis; IEA:Ensembl.
DR GO; GO:0021793; P:chemorepulsion of branchiomotor axon; IEA:Ensembl.
DR GO; GO:0035050; P:embryonic heart tube development; IEA:Ensembl.
DR GO; GO:0021612; P:facial nerve structural organization; IEA:Ensembl.
DR GO; GO:0021615; P:glossopharyngeal nerve morphogenesis; IEA:Ensembl.
DR GO; GO:0099558; P:maintenance of synapse structure; IEA:Ensembl.
DR GO; GO:0021784; P:postganglionic parasympathetic fiber development; IEA:Ensembl.
DR GO; GO:0048841; P:regulation of axon extension involved in axon guidance; IEA:Ensembl.
DR GO; GO:0050923; P:regulation of negative chemotaxis; IEA:Ensembl.
DR GO; GO:0048485; P:sympathetic nervous system development; IEA:Ensembl.
DR GO; GO:0097492; P:sympathetic neuron axon guidance; IEA:Ensembl.
DR GO; GO:0021637; P:trigeminal nerve structural organization; IEA:Ensembl.
DR GO; GO:0021644; P:vagus nerve morphogenesis; IEA:Ensembl.
DR CDD; cd00603; IPT_PCSR; 1.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR CDD; cd01181; IPT_plexin_repeat3; 1.
DR CDD; cd12790; RasGAP_plexin_A; 1.
DR CDD; cd11274; Sema_plexin_A4; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR041362; TIG2_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF34; PLEXIN-A4; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 3.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 4.
DR Pfam; PF18020; TIG_2; 1.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 4.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 4.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1893
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010277206"
FT TRANSMEM 1237..1259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 23..506
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT COILED 1263..1290
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1893 AA; 212509 MW; 3EB92F8E896AB080 CRC64;
MKAMPWNWTC LLSHLLVVGM GSSTLLPRQP PPLSQKRSFI TFRGEPAEGF NHLVVDERTG
HIYLGAVNRI YKLSSDLKVL VTHQTGPDED NPKCYPPRIV QTCNEPLTTT NNVNKMLLID
YKENRLIACG SLYQGICKLL RLEDLFKLGE PFHKKEHYLS GVNESGSVFG VIVSYSNLDD
KLFIATAVDG KPEYFPTISS RKLTKNSEAD GMFAYVFHDE FVASMIKIPS DTFTVIPDFD
IYYVYGFSSG NFVYFLTLQP EMVSPPGSTT KEQVYTSKLV RLCKEDTAFN SYVEVPIGCE
RNGVEYRLLQ AAYLSKAGAV LGRTLGVRPD DDLLFTVFSK GQKRKMKSLD ESALCIFILK
QINDRIKERL QSCYRGEGTL DLAWLKVKDI PCSSALLTID DNFCGLDMNA PLGVSEMVRG
IPVFTEDRDR MTSVIAYVYK NHSLAFVGTK SGKLKKIRVD GPRGNALQYE TVQVVDPGPI
LRDMAFSKDH EQLYIMSERQ LTRVPVESCG QYRSCSECLG SGDPHCGWCV LHNTCTRKER
CERSREPRRF ASEIKQCVRL TVHPNNISVS QYNVLLVLET YNVPELSAGV NCTFEDLSEM
DGLVVGNQIQ CYSPAAKEVP RIITENGDHH VVQLQLKSKE TGMTFASTSF VFYNCSVHNS
CLSCVESPYR CHWCKYRHVC THDPKTCSFQ EGRVRLPEDC PQLLRVDKIL VPVEVIKPIT
LKAKNLPQPQ SGQRGYECIL NIQGSEQRVP ALRFNSSSVQ CQNTSYSYEG MEINNLPVEL
TVVWNGHFNI DNPAQNKVYL YKCGAMRESC GLCLKADPDF ECGWCQSPGQ CTLRQHCPAH
ESRWLELSGA NSKCTNPRIT EIIPVTGPRE GGTKVTIRGE NLGLEFRDIA SHVKVAGVEC
SPLVDGYIPA EQIVCEMGEA KPSQHAGFVE ICVAVCRPEF MARSSQLYYF MTLTLSDLKP
SKGPMSGGTQ VTITGTNLNA GSNVVVMFGK QPCLFHRRSS SFIVCNTTSS DEVLELKVTV
QVDRAKIRQD LAFQYVEDPT IVRIEPEWSI VSGNTPIAVW GTHLDLIQNP QIRAKHGGKE
HINICEVLNA TEMTCQAPAL ALGPDHQSDL TERPEEFGFI LDNVQSLLIL NKTNFTYYPN
PVFEAFGPSG ILELKPGTPI ILKGKNLIPP VAGGNVKLNY TVLVGEKPCT VTVSDVQLLC
ESPNLIGKHK VMARVGGMEY SPGMVYIAPD SPLSLPAIVS IAVAGGLLII FIVAVLIAYK
RKSRESDLTL KRLQMQMDNL ESRVALECKE AFAELQTDIH ELTSDLDGAG IPFLDYRNYT
MRVLFPGIED HPVLRDLEVP GYRQERVEKG LKLFAQLINN KVFLLSFIRT LESQRSFSMR
DRGNVASLIM TVLQSKLEYA TDVLKQLLAD LIDKNLESKN HPKLLLRRTE SVAEKMLTNW
FTFLLYKFLK ECAGEPLFSL FCAIKQQMEK GPIDAITGEA RYSLSEDKLI RQQIEYKTLV
LSCVSPDNAN SPEVPVKILN CDTITQVKEK ILDAIFKNVP CSHRPKAADM DLEWRQGSGA
RMILQDEDIT TKIENDWKRL NTVAHYQVPD GAVVALVSKQ VTAYNAVNNS TVSRTSASKY
ENMIRYTGSP DSLRSRTPMI TPDLESGVKM WHLVKNHEHG DQKEGDRGSK MVSEIYLTRL
LATKGTLQKF VDDLFETIFS TAHRGSALPL AIKYMFDFLD EQADKHGIHD PHVRHTWKSN
CLPLRFWVNM IKNPQFVFDI HKNSITDACL SVVAQTFMDS CSTSEHRLGK DSPSNKLLYA
KDIPSYKNWV ERYYSDIGKM PAISDQDMNA YLAEQSRMHM NEFNTMSALS EIFSYVGKYS
EEILGPLDHD DQCGKQKLAY KLEQVITLMS LDS
//
