ID A0A1S3FPK7_DIPOR Unreviewed; 415 AA.
AC A0A1S3FPK7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Frizzled-10 {ECO:0000313|RefSeq:XP_012878493.1};
GN Name=Fzd10 {ECO:0000313|RefSeq:XP_012878493.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012878493.1};
RN [1] {ECO:0000313|RefSeq:XP_012878493.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012878493.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
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DR RefSeq; XP_012878493.1; XM_013023039.1.
DR AlphaFoldDB; A0A1S3FPK7; -.
DR GeneID; 105990599; -.
DR KEGG; dord:105990599; -.
DR CTD; 11211; -.
DR InParanoid; A0A1S3FPK7; -.
DR OrthoDB; 5483535at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF86; FRIZZLED-10; 1.
DR Pfam; PF01534; Frizzled; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM01330; Frizzled; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT TRANSMEM 59..83
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 143..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 228..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 276..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 59..362
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 415 AA; 45995 MW; DCD67A053537A1B1 CRC64;
MAGRLQWTGR EGRPRDGGPG RAGCANPGKF HHVEKSASCA PLCAPGVDVY WSREDKRFAV
VWLAVWSVLC FFSSAFTVLT FLIDPSRFRY PERPIIFLSM CYCVYSVGYI IRLFAGAESI
ACDRDSGQLY VIQEGLESTG CTLVFLVLYY FGMASSLWWV VLALTWFLAA GKKWGHEAIE
AHSSYFHLAA WAIPAVKTIL ILVMRRVAGD ELTGVCYVGS MDVNALTGFV LVPLACYLVV
GTSFILSGFV ALFHIRRVMK TGGENTDKLE KLMVRIGVFS LLYTVPATCV IACYCYERLN
VDYWKALAVQ HKCRVDNQTK SLDCVLAASI PAVEVFMVKV SMLLVVGITS GVWVWTSKTL
QSWRHVCGRR LGRKGRRKPA SVLTGGSGGI YKKAQHPQKP HLGKYELPAQ PPTCV
//
