ID A0A1S3FPT2_DIPOR Unreviewed; 404 AA.
AC A0A1S3FPT2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Sprouty-related, EVH1 domain-containing protein 2 {ECO:0000256|ARBA:ARBA00039299};
GN Name=Spred2 {ECO:0000313|RefSeq:XP_012878034.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012878034.1};
RN [1] {ECO:0000313|RefSeq:XP_012878034.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012878034.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cytoplasmic vesicle,
CC secretory vesicle membrane {ECO:0000256|ARBA:ARBA00004360}; Peripheral
CC membrane protein {ECO:0000256|ARBA:ARBA00004360}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004360}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR RefSeq; XP_012878034.1; XM_013022580.1.
DR AlphaFoldDB; A0A1S3FPT2; -.
DR GeneID; 105990224; -.
DR CTD; 200734; -.
DR OrthoDB; 3031266at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR CDD; cd10574; EVH1_SPRED-like; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR023337; KBD.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041937; SPRE_EVH1.
DR InterPro; IPR007875; Sprouty.
DR InterPro; IPR000697; WH1/EVH1_dom.
DR PANTHER; PTHR11202:SF11; SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR11202; SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER; 1.
DR Pfam; PF05210; Sprouty; 1.
DR Pfam; PF00568; WH1; 1.
DR SMART; SM00461; WH1; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51488; KBD; 1.
DR PROSITE; PS50229; WH1; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671}.
FT DOMAIN 5..122
FT /note="WH1"
FT /evidence="ECO:0000259|PROSITE:PS50229"
FT DOMAIN 197..252
FT /note="KBD"
FT /evidence="ECO:0000259|PROSITE:PS51488"
FT REGION 127..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 270..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 404 AA; 46356 MW; 5CDDBB69CC30D2F9 CRC64;
MTEETHPDDD SYIVRVKAVV MTRDDSSGGW FPQEGGGISR VGVCKVMHPE GSGRSGFLIH
GERQKDKLVV LECYVRKDLV YTKANPTFHH WKVDNRKFGL TFQSPADARA FDRGVRKAIE
DLIEGSTTSS STIHNEAELG DDDVFTTATD SSSNSSQKRE QPTRTISSPT SCEHRRIYTL
DPYPTDHYHL DQRMPRPYPQ VSFPEDDEEV VRINPREKIW MTGYEDYRHA PVRGKYLDPA
EDADSYVHFA KGEGPKHDYN YPYVDSSDFG LAEDPKGRGG SVIKTQPPRG SKGRRRKEDG
ERSRCVYCRD MFNHEENRRG RCQDAPDPVR TCIRRVSCMW CAHSMLYHCM SDPEGDYTDP
CSCDTSDEQF CLRMTGWSYP VWKRSRELRV GIRGREENPL LENI
//
