ID   A0A1S3FQ96_DIPOR        Unreviewed;      1054 AA.
AC   A0A1S3FQ96;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Transient receptor potential cation channel subfamily M member 8 {ECO:0000313|RefSeq:XP_012878540.1};
GN   Name=Trpm8 {ECO:0000313|RefSeq:XP_012878540.1};
OS   Dipodomys ordii (Ord's kangaroo rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC   Dipodomyinae; Dipodomys.
OX   NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012878540.1};
RN   [1] {ECO:0000313|RefSeq:XP_012878540.1}
RP   IDENTIFICATION.
RC   TISSUE=Kidney {ECO:0000313|RefSeq:XP_012878540.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_012878540.1; XM_013023086.1.
DR   AlphaFoldDB; A0A1S3FQ96; -.
DR   STRING; 10020.ENSDORP00000000941; -.
DR   GeneID; 105990608; -.
DR   KEGG; dord:105990608; -.
DR   CTD; 79054; -.
DR   InParanoid; A0A1S3FQ96; -.
DR   OrthoDB; 201873at2759; -.
DR   Proteomes; UP000081671; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR041491; TRPM_SLOG.
DR   PANTHER; PTHR13800:SF9; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 8; 1.
DR   PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF18139; LSDAT_euk; 1.
PE   4: Predicted;
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_012878540.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT   TRANSMEM        643..662
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        674..707
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        749..768
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        774..794
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        814..834
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        905..934
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          116..366
FT                   /note="TRPM SLOG"
FT                   /evidence="ECO:0000259|Pfam:PF18139"
FT   DOMAIN          693..935
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
SQ   SEQUENCE   1054 AA;  122208 MW;  23A8F4D913EA1467 CRC64;
     MSFEGARLSM RSRRNGALGS TRTLYSSVSR STDVSYNESD LVNFIQANFK KRECVFFTKD
     SKATENVCKC GYTQSQHVEG TQINDNDKWN YKKHTKEFPT DAFGDIQFET LGKKGKYIRL
     SCDTDAETLY ELLTQHWHLK TPNLVISVTG GAKNFALKPR MRKIFSRLIY IAQSKGAWIL
     TGGTHYGLMK YIGEVVRDNT ISRNSEENIT AIGIAAWGMV SNRDTLIRNC DDEGYFSAQY
     IMDDFKRDPL YILDNNHTHL LLVDNGCHGH PTIEAKLRNQ LEKYISERTS QDSNYGGKIP
     IVCFAQGGGR ETLKAINTSI KSKIPCVVVE GSGQIADVIA SLVDVEDALT SSMVKEKLVR
     FLPRTVSRLP EEEIENWIKW LKEILENSHL LTVIKMEEAG DEIVSNAISY ALYKAFSTNE
     QDKDNWNGQL KLLLEWNQLE LASDEIFTND RRWESADLQE VMFTALIKDR PKFVRLFLEN
     GLNLQKFLTN EVLTELFSSH FSSLVYQNLQ IAKNSYNDAL LTFVWKLVAN FRRSFWKEDR
     NSRDEVDVEL HDVSFTTRHP LQALFIWAIL QNKKELSKVI WEQTRGCTLA ALGASKLLKT
     LAKVKNDINA AGESEELANE YETRANFLSK QWYGEISRDT KNWKIILCLF IIPLVGCGLV
     SFRKKPIDKH KKLLWYYVAF FTSPFVVFSW NVVFYIAFLL LFAYVLLMDF HSVPHTPELI
     LYALVFVLFC DEVRQWYMNG VNYFTDLWNV MDTLGLFYFI AGIVFRLHSS NKNSLYSGRV
     IFCLDYIIFT LRLIHIFTVS RNLGPKIIML QRMLIDVFFF LFLFAVWMVA FGVARQGILR
     QNEQRWRWIF RSVIYEPYLA MFGQVPSDVD GTTYDFSHCT FSGNESKPLC VELDEHNLPR
     FPEWITIPLV CIYMLSTNIL LVNLLVAMFG YTVGIVQENN DQVWKFQRYF LVQEYCSRLN
     IPFPFVVFAY FYMVVKKCFK CCCKERNMES SACCFRNEDN ETLAWEGVMK ENYLVKINTK
     GSDNAEEMRH RFRQLDTKLN DLKGLLKEIV NKIK
//