ID A0A1S3FQI7_DIPOR Unreviewed; 164 AA.
AC A0A1S3FQI7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Cyclin-dependent kinases regulatory subunit {ECO:0000256|RuleBase:RU311113};
GN Name=Cks2 {ECO:0000313|RefSeq:XP_012878823.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012878823.1};
RN [1] {ECO:0000313|RefSeq:XP_012878823.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012878823.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Binds to the catalytic subunit of the cyclin dependent
CC kinases and is essential for their biological function.
CC {ECO:0000256|ARBA:ARBA00002449, ECO:0000256|RuleBase:RU311113}.
CC -!- SUBUNIT: Forms a homohexamer that can probably bind six kinase
CC subunits. {ECO:0000256|ARBA:ARBA00011253}.
CC -!- SIMILARITY: Belongs to the CKS family. {ECO:0000256|ARBA:ARBA00007782,
CC ECO:0000256|RuleBase:RU311113}.
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DR RefSeq; XP_012878823.1; XM_013023369.1.
DR AlphaFoldDB; A0A1S3FQI7; -.
DR STRING; 10020.ENSDORP00000025357; -.
DR GeneID; 105990851; -.
DR KEGG; dord:105990851; -.
DR CTD; 1164; -.
DR InParanoid; A0A1S3FQI7; -.
DR OrthoDB; 204504at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:InterPro.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.170.10; Cyclin-dependent kinase, regulatory subunit; 1.
DR InterPro; IPR000789; Cyclin-dep_kinase_reg-sub.
DR InterPro; IPR036858; Cyclin-dep_kinase_reg-sub_sf.
DR PANTHER; PTHR23415:SF49; CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT 2; 1.
DR PANTHER; PTHR23415; CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7; 1.
DR Pfam; PF01111; CKS; 1.
DR PRINTS; PR00296; CYCLINKINASE.
DR SMART; SM01084; CKS; 1.
DR SUPFAM; SSF55637; Cell cycle regulatory proteins; 1.
DR PROSITE; PS00945; CKS_2; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU311113};
KW Cell division {ECO:0000256|ARBA:ARBA00022618,
KW ECO:0000256|RuleBase:RU311113};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671}.
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 46..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..68
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 164 AA; 18503 MW; 5BA17930AA44537C CRC64;
MSESEQDQPL GGEQRGPKLS FTLSSTSSIK AHHESAIRLA WLRQGGEAVR EPEPSGVREG
EGDASGRSAR PDVVRSPNSG TKVVSANPWG LRPRHSTNAW LSVTRHVMLP RELSKQVPKT
HLMSEEEWRR LGVQQSLGWV HYMIHEPEPH ILLFRRPLPK EQQK
//
