ID   A0A1S3FQM8_DIPOR        Unreviewed;      1305 AA.
AC   A0A1S3FQM8;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=ubiquitinyl hydrolase 1 {ECO:0000256|ARBA:ARBA00012759};
DE            EC=3.4.19.12 {ECO:0000256|ARBA:ARBA00012759};
GN   Name=Usp40 {ECO:0000313|RefSeq:XP_012878329.1};
OS   Dipodomys ordii (Ord's kangaroo rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC   Dipodomyinae; Dipodomys.
OX   NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012878329.1};
RN   [1] {ECO:0000313|RefSeq:XP_012878329.1}
RP   IDENTIFICATION.
RC   TISSUE=Kidney {ECO:0000313|RefSeq:XP_012878329.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC         and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC         residue protein attached to proteins as an intracellular targeting
CC         signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707};
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DR   RefSeq; XP_012878329.1; XM_013022875.1.
DR   STRING; 10020.ENSDORP00000016702; -.
DR   GeneID; 105990433; -.
DR   KEGG; dord:105990433; -.
DR   CTD; 55230; -.
DR   InParanoid; A0A1S3FQM8; -.
DR   OrthoDB; 51419at2759; -.
DR   Proteomes; UP000081671; Unplaced.
DR   GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd02659; peptidase_C19C; 1.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR001394; Peptidase_C19_UCH.
DR   InterPro; IPR018200; USP_CS.
DR   InterPro; IPR028889; USP_dom.
DR   PANTHER; PTHR24006; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR   PANTHER; PTHR24006:SF842; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 40; 1.
DR   Pfam; PF00443; UCH; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   PROSITE; PS00972; USP_1; 1.
DR   PROSITE; PS00973; USP_2; 1.
DR   PROSITE; PS50235; USP_3; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801,
KW   ECO:0000313|RefSeq:XP_012878329.1};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW   Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT   DOMAIN          41..478
FT                   /note="USP"
FT                   /evidence="ECO:0000259|PROSITE:PS50235"
FT   REGION          718..744
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          979..1012
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1261..1305
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1261..1275
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1305 AA;  146792 MW;  F7EC633E4CD88BAB CRC64;
     MFGDLFEEDY SSVSNNHYGK GKNLKTKTLE PPAPREFTNL SGIRNQGGTC YLNSLLQTLH
     FTPEFREALF SLGPEELGSL EDKDKPDAKV RIIPLQLQRL FAQLLLLDQE AASTTDLTDS
     FGWTSNEEMR QHDVQELNRI LFSALETSLV GTSGHDLINR LYHGTVVNQI VCKECENISE
     KQEDFLDLTV AVKNVSSLED ALWNMYVEEE VFDYDNLYHC GTCDRLVKAA KSAKLRKLPP
     FLTISLLRFN FDFVKCERYK DTSCYTFPLR INLKPFCEQS ELDDSGYMYD LFSVIIHKGG
     CYGGHYHVYI KDVDHLGNWQ FQEEKRKPDV NLEALPNEEE TDDPLMILKA IFLQEKSSLI
     SVDQLGQKLL KKTGISWNKK YRRQHGPLRK FLQLHSQIFL LSSDESTVSL LKNGSLQAES
     DFQRNDHQTS KCPGLNGSPT CPHWFDINDS KVQPIEEKDI AQQFQGKESA YMLFYRKSQL
     QRPPEARANP RYRVPCHLLK EMDAANTELQ MKRTECDSAN NNFELHLHLG PHYRFCNGAL
     HPGTSQAESV WDLTFDKRKT LGDLRQSIFQ LLQFWEGDMV LSVAKCVPAG LHIYQTLDGD
     ELTLCEAEIA DGEDIFVWNG VEVGGVQIQT GVDCEPLLIH VLHVETSAEG ETQGQLVETP
     HVFPANAEMR TVFTTLAMPV GIILVNLAEP GGDEWTPIPQ KDLKKTFREQ GLRNGSSLLL
     QHSHSANNRK TGLNEAKKGS NLKQNGLDRN CSSLGLNSTY SLGPDASVVF DIRIKAIKEL
     KLMEELAENS CLRPVDRNGK LLCPVPDSAT LKEAEVRLGS TLALCLGKAP TSSQLFLFFA
     LGTDLQPGVE LEVIVEETLS VRDCLKIMLK KSGLSGGAWH LRKMDWCYEA GEPLCEEDAT
     LKELRICSGD TLLLMKGKLP PLGFLKVPIW WYQPWGPSGH QESRYQPNCA PSQGSSWRVA
     SSQGEDTVIV IPYRVGGSPK TRLRPRPAEP TRACRDGFRT GRCGPPPAGP ASISISEGHR
     GALRCVRHGV RGRSRHLPGP GRWTEAARSW PRAAALPENE QRRPGDQDAL ALAMALPFAS
     ELAFWPPAFL RAWTVESKRP RRLLRADRQQ LREYKLGRKA EICLEALEKE ESLGPQDMLL
     RTQLRIPGER AYARALDLVW DAARGCTAGS LRQRVADFYS LPVEKIEIAK YCPEKFEWLP
     ISSWNQQIAK RKKKKKQDNL QGAPYYLKDG DIIGVKNLLV EEDDEDFSTV SDDLGKERQK
     QLALGKKKSR EALRAHSSDL FSSAGTPAQP RGPEASLSIH VGSFR
//