ID A0A1S3FR15_DIPOR Unreviewed; 440 AA.
AC A0A1S3FR15;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Integral membrane protein GPR180 isoform X1 {ECO:0000313|RefSeq:XP_012878469.1};
GN Name=Gpr180 {ECO:0000313|RefSeq:XP_012878469.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012878469.1};
RN [1] {ECO:0000313|RefSeq:XP_012878469.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012878469.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_012878469.1; XM_013023015.1.
DR AlphaFoldDB; A0A1S3FR15; -.
DR GeneID; 105990577; -.
DR KEGG; dord:105990577; -.
DR CTD; 160897; -.
DR InParanoid; A0A1S3FR15; -.
DR OMA; DHSCTEK; -.
DR OrthoDB; 5391031at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:InterPro.
DR InterPro; IPR047831; GPR180/TMEM145.
DR InterPro; IPR019336; GPR180/TMEM145_TM.
DR PANTHER; PTHR23252:SF29; INTEGRAL MEMBRANE PROTEIN GPR180; 1.
DR PANTHER; PTHR23252; INTIMAL THICKNESS RECEPTOR-RELATED; 1.
DR Pfam; PF10192; GpcrRhopsn4; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..440
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010189723"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 205..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 281..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 324..344
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 356..377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 389..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 144..405
FT /note="GPR180/TMEM145 transmembrane"
FT /evidence="ECO:0000259|Pfam:PF10192"
SQ SEQUENCE 440 AA; 49698 MW; D92DBC6A2BA664D1 CRC64;
MRGLRLLAVA LTCCWWPQGS HGKTLRGSFS SAAARDAQGQ SIGHFEFHGD HALLCVRINN
IAVAVAKEAK LYLFQAQEWL KLQESSPGYG CSEKLTKAQL TMTVNQTEHN LTVSQIPYPQ
TWHVFYADKY TCKDEEENSQ EDEIPFEMML LNPDAEGNPF DHFSARESGL HEFFFLLVLV
YFVVACIYAQ SLWQAIKKGG PMHMILKVLT TALLLQAGSA LANYIHFSRY SKDGVGVPFM
GSLAEFFDIA SQIQMLYLLL SLCMGWTIVR MKKSQSRPLQ WDSTPASTGI AVFIVVTQSI
LLLWEQFEDT SHHSSHSHHN IAGILLIILR ICLAFSLGCG LYQIITVERS TLKREFYITF
AKGCTLWFLC HPALAFISVM FNDYQRDKVI IIGVILCQSV SMVILYRLFL SHSLYWEVSS
LSSVTLPLTI SSAHRSRPHF
//
