ID A0A1S3FRA8_DIPOR Unreviewed; 692 AA.
AC A0A1S3FRA8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Rabphilin-3A isoform X1 {ECO:0000313|RefSeq:XP_012878564.1};
GN Name=Rph3a {ECO:0000313|RefSeq:XP_012878564.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012878564.1};
RN [1] {ECO:0000313|RefSeq:XP_012878564.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012878564.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_012878564.1; XM_013023110.1.
DR AlphaFoldDB; A0A1S3FRA8; -.
DR STRING; 10020.ENSDORP00000022599; -.
DR GeneID; 105990666; -.
DR KEGG; dord:105990666; -.
DR CTD; 22895; -.
DR OrthoDB; 590187at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd04035; C2A_Rabphilin_Doc2; 1.
DR CDD; cd08384; C2B_Rabphilin_Doc2; 1.
DR CDD; cd15762; FYVE_RP3A; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR041282; FYVE_2.
DR InterPro; IPR028698; FYVE_RPH3A.
DR InterPro; IPR010911; Rab_BD.
DR InterPro; IPR043566; Rabphilin/DOC2/Noc2.
DR InterPro; IPR047022; Rabphilin_Doc2_C2A.
DR InterPro; IPR001565; Synaptotagmin.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45729; RABPHILIN, ISOFORM A; 1.
DR PANTHER; PTHR45729:SF3; RABPHILIN-3A; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF02318; FYVE_2; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR PRINTS; PR00399; SYNAPTOTAGMN.
DR SMART; SM00239; C2; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50916; RABBD; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 40..157
FT /note="RabBD"
FT /evidence="ECO:0000259|PROSITE:PS50916"
FT DOMAIN 88..145
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 390..512
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 548..681
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 27..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 164..386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..206
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..304
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 692 AA; 76594 MW; 48BE1708EE7EC451 CRC64;
MTDTAVRSSS GRWMYPSDRP LQAKLQAGWS VHPGAQTDRQ RKQEELTDEE KEIINRVIAR
AEKMEEMEQE RIGRLVDRLE NMRKNVAGDG VNRCILCGEQ LGTLGSTCVV CEDCKKNVCT
KCGVETTNNR PHPVWLCKIC LEQREVWKRS GAWFFKGFPK QVLPQPMPIT RSKALQPGSE
QHTSEPKPAV RPSTQDDTEE RRSLGHKTGP GLASAPGRGS YGPPVRRASE AQMNTPPRDP
ESRDVGHGGG AGDASRSPAG LRRANSVQAS RQTPASGPSP APPQPAQPGP PRGGRAPPAP
AGRLPEQRPE GTPSDPGHPG ATGPPREDRT GAAEGFAMAG AREDRAHPPG RYPQVPAASA
QPAPTPARQP PPPEEDEDEA NSYDSDEATT LGALEFSLLY EQDNSSLQCT IIKAKGLKPM
DSNGLADPYV KLHLLPGASK SNKLRTKTLR NTRNPVWNET LVYHGITDED MQRKTLRISV
CDEDKFGHNE FIGETRFSLK KLKPNQRKNF NICLERVIPM KRAGTTGSAR GMALYEEEQV
ERLGDVEERG KILVSLMYST QQGGLIVGIV RCVHLAAMDA NGYSDPFVKL WLKPDMGKKA
KHKTQIKKKT LNPEFNEEFF YDIKHSDLAK KSLDISVWDY DIGKSNDYIG GCQLGISAKG
ERLKHWYECL KNKDKKIERW HQLQNENHVS SD
//
