ID   A0A1S3FT19_DIPOR        Unreviewed;       524 AA.
AC   A0A1S3FT19;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Protein tweety homolog {ECO:0000256|RuleBase:RU361114};
GN   Name=Ttyh3 {ECO:0000313|RefSeq:XP_012878997.1};
OS   Dipodomys ordii (Ord's kangaroo rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC   Dipodomyinae; Dipodomys.
OX   NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012878997.1};
RN   [1] {ECO:0000313|RefSeq:XP_012878997.1}
RP   IDENTIFICATION.
RC   TISSUE=Kidney {ECO:0000313|RefSeq:XP_012878997.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Probable chloride channel. {ECO:0000256|RuleBase:RU361114}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU361114};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU361114}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the tweety family.
CC       {ECO:0000256|ARBA:ARBA00009849, ECO:0000256|RuleBase:RU361114}.
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DR   RefSeq; XP_012878997.1; XM_013023543.1.
DR   AlphaFoldDB; A0A1S3FT19; -.
DR   STRING; 10020.ENSDORP00000023966; -.
DR   GeneID; 105990991; -.
DR   KEGG; dord:105990991; -.
DR   CTD; 80727; -.
DR   InParanoid; A0A1S3FT19; -.
DR   OMA; ECATTIK; -.
DR   OrthoDB; 5393599at2759; -.
DR   Proteomes; UP000081671; Unplaced.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005229; F:intracellular calcium activated chloride channel activity; IEA:Ensembl.
DR   CDD; cd07912; Tweety_N; 1.
DR   InterPro; IPR006990; Tweety.
DR   PANTHER; PTHR12424:SF4; PROTEIN TWEETY HOMOLOG 3; 1.
DR   PANTHER; PTHR12424; TWEETY-RELATED; 1.
DR   Pfam; PF04906; Tweety; 1.
PE   3: Inferred from homology;
KW   Chloride {ECO:0000256|RuleBase:RU361114};
KW   Chloride channel {ECO:0000256|RuleBase:RU361114};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Ion channel {ECO:0000256|RuleBase:RU361114};
KW   Ion transport {ECO:0000256|RuleBase:RU361114};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361114};
KW   Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361114};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361114};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361114}.
FT   TRANSMEM        42..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   TRANSMEM        85..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   TRANSMEM        210..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   TRANSMEM        238..257
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   TRANSMEM        388..409
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361114"
FT   REGION          415..435
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          482..524
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        415..429
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   524 AA;  57614 MW;  D534216BA9DBA248 CRC64;
     MAGVSYAAPW WVSLLHRLPH FDLRWEATSS QFRPEDADYQ QALLLVGAVA LACLALDLLF
     LLFYSFWLCC RRRKSDEHLD ADCCCTAWCV IIATLVCSAG IAVGFYGNGE TSDGVHRATY
     SLRHANRTVS GVEDRVWDTV AALNRTAEPS LQSLARQMAG RPEPLRAVQR LQGLLETLQG
     YTAAIPFWRN PGVSLEALAE QVDLYDWYRW LGYLGLLLLD VIICLLVLVG LIRSSKGILV
     GVCLLGVLAL VISWGALGLE LAVSVGSSDF CVSPDTYVTK VVDEYTVLSG DILQYYLACS
     PRAANPFQQK LSGSHKALVE MQDIVAELLK SVTRENPASK DHLLRVQEVL NGTEVNLQHL
     TALVDCRSLH LDYVQALMGF CYDGVEGLIY LALFSFVTAL MFSSIVCSIP HTWQQKRGPE
     EDGEEEAAPG QRQAQDSLYR VHMPSLYSCG SSYGSEASIP AAAHTVSNAP VTEYMSQNAN
     FQNPRCENTP LIGRESPPPS YTSSMRAKYL ATSQPRPDSS SSAH
//