ID A0A1S3FVL8_DIPOR Unreviewed; 704 AA.
AC A0A1S3FVL8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Protein Hook homolog 3 {ECO:0000313|RefSeq:XP_012879882.1};
GN Name=Hook3 {ECO:0000313|RefSeq:XP_012879882.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012879882.1};
RN [1] {ECO:0000313|RefSeq:XP_012879882.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012879882.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the hook family.
CC {ECO:0000256|ARBA:ARBA00006946}.
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DR RefSeq; XP_012879882.1; XM_013024428.1.
DR AlphaFoldDB; A0A1S3FVL8; -.
DR STRING; 10020.ENSDORP00000001424; -.
DR GeneID; 105991741; -.
DR KEGG; dord:105991741; -.
DR CTD; 84376; -.
DR InParanoid; A0A1S3FVL8; -.
DR OMA; DAKYRKC; -.
DR OrthoDB; 50921at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR GO; GO:0005801; C:cis-Golgi network; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0070695; C:FHF complex; IEA:Ensembl.
DR GO; GO:0030897; C:HOPS complex; IEA:Ensembl.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0000242; C:pericentriolar material; IEA:Ensembl.
DR GO; GO:0034452; F:dynactin binding; IEA:Ensembl.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:Ensembl.
DR GO; GO:0045503; F:dynein light chain binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0008017; F:microtubule binding; IEA:Ensembl.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IEA:Ensembl.
DR GO; GO:0030705; P:cytoskeleton-dependent intracellular transport; IEA:InterPro.
DR GO; GO:0045022; P:early endosome to late endosome transport; IEA:Ensembl.
DR GO; GO:0007032; P:endosome organization; IEA:Ensembl.
DR GO; GO:0008333; P:endosome to lysosome transport; IEA:Ensembl.
DR GO; GO:0051645; P:Golgi localization; IEA:Ensembl.
DR GO; GO:0022027; P:interkinetic nuclear migration; IEA:Ensembl.
DR GO; GO:0007040; P:lysosome organization; IEA:Ensembl.
DR GO; GO:0034454; P:microtubule anchoring at centrosome; IEA:Ensembl.
DR GO; GO:0050768; P:negative regulation of neurogenesis; IEA:Ensembl.
DR GO; GO:0097150; P:neuronal stem cell population maintenance; IEA:Ensembl.
DR GO; GO:0071539; P:protein localization to centrosome; IEA:Ensembl.
DR GO; GO:1905719; P:protein localization to perinuclear region of cytoplasm; IEA:Ensembl.
DR CDD; cd22226; HkD_Hook3; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR008636; Hook_C.
DR InterPro; IPR043936; HOOK_N.
DR PANTHER; PTHR18947; HOOK PROTEINS; 1.
DR PANTHER; PTHR18947:SF38; PROTEIN HOOK HOMOLOG 3; 1.
DR Pfam; PF05622; HOOK; 1.
DR Pfam; PF19047; HOOK_N; 1.
DR SUPFAM; SSF116907; Hook domain; 1.
DR PROSITE; PS50021; CH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671}.
FT DOMAIN 10..126
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 668..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 171..430
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 475..643
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 672..695
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 704 AA; 82054 MW; 4B2EC3FCBCC4F8A5 CRC64;
MFNVESVERV ELCESLLTWI QTFNVDTPCQ TVEDLTNGVV MAQVLQKIDP AYFDENWLNR
IKTEVGDNWR LKISNLKKIL KGILDYNHEI LGQQINDFTL PDVNLIGEHS DAAELGRMLQ
LILGCAVNCE QKQEYIQAIM MMEESVQHVV MTAIQELMSK ESPVSSGNDA YVDLDRQLKK
TTEELNEALS AKEEISQRCH ELDMQVAALQ EEKSSLLAEN QILMERLNQS DSIEDPNSPA
GRRHLQLQTQ LEQLQEETFR LEAAKDDYRI RCEELEKEIS ELRQQNDELT TLADEAQSLK
DEIDVLRHSS DKVSKLEGQV ESYKKKLEDL GDLRRQVKLL EEKNTMYMQN TVSLEEELRK
ANAARGQLET YKRQVVELQN RLSEESKKAD KLDFEYKRLK EKVDSLQKEK DRLRTERDSL
KETIEELRCV QAQEGQLTTQ GNRFLFYSFR EKLIRLQHEN KMLKIHQEGS DNEKIALLQS
LLDDANLRKN ELETENRLVN QRLLEVQSQV EELQKSLQDQ GSKAEDSILL KKKLEEHLEK
LHEANNELQK KRAIIEDLEP RFNNSSLKIE ELQEALRKKE EEMKQMEERY KKYLEKAKSV
IRTLDPKQNQ GAAPEIQALK NQLQERERLF HSLEKEYEKT KSQREMEEKY IVSAWYNMGM
TLHKKAAEDR LASTGSGQSF LARQRQATSA RRSYPGHVQP ATAR
//
