ID A0A1S3FY62_DIPOR Unreviewed; 1272 AA.
AC A0A1S3FY62;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Insulin receptor substrate 4 {ECO:0000313|RefSeq:XP_012881315.1};
GN Name=Irs4 {ECO:0000313|RefSeq:XP_012881315.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012881315.1};
RN [1] {ECO:0000313|RefSeq:XP_012881315.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012881315.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_012881315.1; XM_013025861.1.
DR AlphaFoldDB; A0A1S3FY62; -.
DR STRING; 10020.ENSDORP00000011859; -.
DR GeneID; 105992800; -.
DR KEGG; dord:105992800; -.
DR CTD; 8471; -.
DR InParanoid; A0A1S3FY62; -.
DR OrthoDB; 4212441at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0005158; F:insulin receptor binding; IEA:InterPro.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:InterPro.
DR CDD; cd01257; PH_IRS; 1.
DR CDD; cd01204; PTB_IRS; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR039011; IRS.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10614; INSULIN RECEPTOR SUBSTRATE; 1.
DR PANTHER; PTHR10614:SF2; INSULIN RECEPTOR SUBSTRATE 4; 1.
DR Pfam; PF02174; IRS; 1.
DR PRINTS; PR00628; INSULINRSI.
DR SMART; SM01244; IRS; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00310; PTBI; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS51064; IRS_PTB; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Receptor {ECO:0000313|RefSeq:XP_012881315.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671}.
FT DOMAIN 78..199
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 231..335
FT /note="IRS-type PTB"
FT /evidence="ECO:0000259|PROSITE:PS51064"
FT REGION 398..918
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1186..1272
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..452
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 527..570
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 600..614
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..645
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 662..704
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 765..780
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 798..828
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 855..874
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 876..890
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1217..1231
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1232..1272
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1272 AA; 135316 MW; 8034D3E730CCC2E2 CRC64;
MASCSFTRDQ ATRRLRAAAA ATAAALAAVA TTPVLSSGTP TALIGTGSSC PGAMWLSPAT
GSRSDSESEE EDLPVGDEVC KRGYLRKQKH GHRRYFVLKL ETADAPARLE YYENARKFRH
SVRAAAAAAA AAASGAAVPS LIPPRRVITL YQCFSVSQRA DARYRHLIAL FTQDEYFAMV
AENESEQESW YLLLSRLILE SKRRRCGTLS AQPDGEPAPL AAVAAAEPPF YKDVWQVVVK
PRGLGHRKEL SGVFRLCLTD EEVVFVRLNT DVASVVVQLL SIRRCGHSEQ YFFLEVGRST
VIGPGELWMQ VDDCVVAQNM HELFLEKMRA LCADEYRARC RSYSISIGAH LLTLLSARRH
LGMLPLEPGG WLRRSRFEQF YHLRAIGDGE EERLFTRRLI TPSEPEPPST RGRQHLPRAR
RSRRAISVPA SFFRRLEPSP VRDPHPDETP GDEAGEASGS GNSGGKNKPR GKDKEKGSEG
DYMPMNNWGS GNGRGSGGGQ GSSGQGSSSQ SSGGNQCAGG RQGSGGGHGS SGGQGSGGSH
GSGGNQCSGE GQGTAGGQGS GGSQGSGGGH GSGGGQGPRD GHGSGSGKNS GGGKGSGNGK
GSDGDDDRGK SLKKRSYFGK LTQSKQQQML PPPPPPPPPP PPAGATGGKG KSGGRFRLYF
CADRGATKER KEVKETRDTE TPESAARAPY RPRAFDEDED DPYVPMRPGV AAPLASSSDY
MPMAPQNVSA SKKHHSRSPF EDSRGYMMMF PRVSPPPAPS PPRAPDDPNK EDDSKDNDSD
SDYMFMAPGA GAIPKNPRNP QGGSSSKSWS SYFSLPNPFQ SSPLGQSDHS EYVPMLPGKY
LGKGLDKETS SNKGPKDAPS KPSAQGSFSK PRDGGSSLKP SDDEPPQNKA KRPSRLSFIT
KGNKIKPKPQ KSTRELRETD RASAYVNIDF TKRDRNLPTP FAQALPNSWG IIAGPRHSAF
SNYFSVRLGV PFPNPASRLS DLLRAIPGAN PFSLDGARWP HPSIPVSAPS SNANVEEGDY
IEVIFNPAMT PPVPFADRTI RYDAETGRIY VVDPFSECCM DISLSPSRSA EPTPVARLLL
GEVHESERPQ SRSQSFFLAA RAAVSAFPTD SLERDLAAAS PAARATIPPL ALGQAIAAAS
ALAAAPGMGA AAAGLEAAAG FDSASTRWLQ PVANVLEAEA VNRAQSVARG SNPGAPNPAA
DLAGGENVAG GAAAAAAAPR PPPPPPRHGR VPRPPQRADS DNNDNDDDEA TYMRMDYARR
DPNKFDSPKR GW
//
