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Database: UniProt
Entry: A0A1S3FZ63_DIPOR
LinkDB: A0A1S3FZ63_DIPOR
Original site: A0A1S3FZ63_DIPOR 
ID   A0A1S3FZ63_DIPOR        Unreviewed;      1914 AA.
AC   A0A1S3FZ63;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   05-JUN-2019, entry version 14.
DE   SubName: Full=receptor-type tyrosine-protein phosphatase delta isoform X1 {ECO:0000313|RefSeq:XP_012881848.1};
GN   Name=Ptprd {ECO:0000313|RefSeq:XP_012881848.1};
OS   Dipodomys ordii (Ord's kangaroo rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha;
OC   Heteromyidae; Dipodomyinae; Dipodomys.
OX   NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012881848.1};
RN   [1] {ECO:0000313|RefSeq:XP_012881848.1}
RP   IDENTIFICATION.
RC   TISSUE=Kidney {ECO:0000313|RefSeq:XP_012881848.1};
RG   RefSeq;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein]
CC         + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136,
CC         Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48;
CC         Evidence={ECO:0000256|SAAS:SAAS01128831};
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DR   RefSeq; XP_012881848.1; XM_013026394.1.
DR   GeneID; 105993216; -.
DR   CTD; 5789; -.
DR   OrthoDB; 220353at2759; -.
DR   Proteomes; UP000081671; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR   CDD; cd00063; FN3; 8.
DR   Gene3D; 2.60.40.10; -; 11.
DR   Gene3D; 3.90.190.10; -; 2.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000242; PTPase_domain.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   InterPro; IPR000387; TYR_PHOSPHATASE_dom.
DR   Pfam; PF00041; fn3; 7.
DR   Pfam; PF07679; I-set; 2.
DR   Pfam; PF00102; Y_phosphatase; 2.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM00060; FN3; 8.
DR   SMART; SM00409; IG; 4.
DR   SMART; SM00408; IGc2; 3.
DR   SMART; SM00194; PTPc; 2.
DR   SMART; SM00404; PTPc_motif; 2.
DR   SUPFAM; SSF48726; SSF48726; 3.
DR   SUPFAM; SSF49265; SSF49265; 5.
DR   SUPFAM; SSF52799; SSF52799; 2.
DR   PROSITE; PS50853; FN3; 8.
DR   PROSITE; PS50835; IG_LIKE; 3.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000081671};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00160,
KW   ECO:0000256|SAAS:SAAS01031440};
KW   Membrane {ECO:0000256|SAAS:SAAS00841963, ECO:0000256|SAM:Phobius};
KW   Protein phosphatase {ECO:0000256|SAAS:SAAS01031415};
KW   Receptor {ECO:0000313|RefSeq:XP_012881848.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW   Repeat {ECO:0000256|SAAS:SAAS00923712};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00742775,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00747680,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21   1914       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5010310039.
FT   TRANSMEM   1246   1269       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       24    114       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      126    215       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      223    305       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      312    402       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      407    503       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      505    594       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      599    696       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      701    800       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      801    894       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      899    994       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      999   1085       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN     1336   1591       Tyrosine-protein phosphatase.
FT                                {ECO:0000259|PROSITE:PS50055}.
FT   DOMAIN     1511   1582       TYR_PHOSPHATASE_2. {ECO:0000259|PROSITE:
FT                                PS50056}.
FT   DOMAIN     1623   1870       Tyrosine-protein phosphatase.
FT                                {ECO:0000259|PROSITE:PS50055}.
FT   DOMAIN     1800   1873       TYR_PHOSPHATASE_2. {ECO:0000259|PROSITE:
FT                                PS50056}.
FT   REGION      589    610       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1S3FZ63}.
FT   REGION     1278   1297       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1S3FZ63}.
FT   ACT_SITE   1532   1532       Phosphocysteine intermediate.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00160}.
FT   ACT_SITE   1823   1823       Phosphocysteine intermediate.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00160}.
SQ   SEQUENCE   1914 AA;  214930 MW;  C7E665C56699087E CRC64;
     MVHITRPLLL LLAFFLRVDA ETPPRFTRTP VDQTGVSGGV ASFICQATGD PRPKIVWNKK
     GKKVSNQRFE VIEFDDGSGS VLRIQPLRTP RDEAIYECVA SNNVGEISVS TRLTVLREDQ
     IPRGFPTIDM GPQLKVVERT RTATMLCAAS GNPDPEITWF KDFLPVDTSN NNGRIKQLRS
     GALQIEQSEE SDQGKYECVA TNSAGTRYSA PANLYVRVRR VPPRFSIPPT NHEIMPGGSV
     NITCVAVGSP MPYVKWMLGA EDLTPEDDMP IGRNVLELND VRQSANYTCV AMSTLGVIEA
     IAQITVKALP KPPGTPVVTE STATSITLTW DSGNPEPVSY YIIQHKPKNS EEPYKEIDGV
     ATTRYSVAGL SPYSDYEFRV VAVNNIGRGP PSEPVLTQTS EQAPSSAPRD VQARMLSSTT
     ILVQWKEPEE PNGQIQGYRV YYTMDPTQHV NNWMKHNVAD SQITTIGNLV PQKTYSVKVL
     AFTSIGDGPL SSDIQVITQT GVPGQPLNFK AEPESETSIL LSWTPPRSDT IASYELVYKD
     GELGEEQRVT IEPGTSYRLQ GLKPNSLYYF RLAARSPQGL GASTTEISAR TMQSKPSAPP
     QDISCTSPSS TSILVSWQPP PVEKQNGIIT EYSLKYIAVD GEDDKPHEVL GIPSDTTKYL
     LEQLEKWTEY RITVTAHTDV GPGPESLSIL IRTDEDVPSG PPRKVEVEAV NSTSVKVSWR
     SPVPNKQHGQ IRGYQVHYVR MENGEPKGQP MLKDVMLADA QDMIISGLQP ETSYSLTVTA
     YTTKGDGARS KPKLVSTTGA VPGKPRLVIN HTQMNTALIQ WHPPVDTFGP LQGYRLKFGR
     KDMEPLTTLE FSEKEDHFTA TDIHKGASYV FRLSARNKVG FGEEMVKEIT VPEEIPTGFP
     QNLHSEGTTS TSVQLSWQPP VLAERNGIIT KYTLLYRDIN IPLHPLEQLL VPADTSMTLT
     GLKPDTTYDV KVRAHTSKGP GPYSPSVQFR TLPVDQAVFA KNFHVKAVMK TSVLLSWEIP
     ENYNSAMPFK ILYDDGKMVE EVDGRATQKL IVNLKPEKSY SFVLTNRGNS AGGLQHRVTA
     KTAPDVLRTK PAFIGKTNLD GMITVQLPEV PANENIKGYY IIIVPLKKSR GKFIKPWESP
     DEMELDELLK EISRKRRSIR YGREVELKPY IAAHFDVLPT EFTLGDDKHY GGFTNKQLQS
     GQEYVFFVLA VMEHAESKMY ATSPYSDPVV SMDLDPQPIT DEEEGLIWVV GPVLAVVFII
     CIVIAILLYK RKRAESESRK SSIPNSKEVP SHHPTDPVEL RRLNFQTPGM ASHPPIPILE
     LADHIERLKA NDNLKFSQEY ESIDPGQQFT WEHSNLEVNK PKNRYANVIA YDHSRVLLSA
     IEGIPGSDYV NANYIDGYRK QNAYIATQGS LPETFGDFWR MIWEQRSATI VMMTKLEERS
     RVKCDQYWPS RGTETHGLVQ VTLLDTVELA TYCVRTFALY KNGSSEKREV RQFQFTAWPD
     HGVPEHPTPF LAFLRRVKTC NPPDAGPMVV HCSAGVGRTG CFIVIDAMLE RIKHEKTVDI
     YGHVTLMRAQ RNYMVQTEDQ YIFIHDALLE AVTCGNTEVP ARNLYAYIQK LTQIETGENV
     TGMELEFKRL ASSKAHTSRF ISANLPCNKF KNRLVNIMPY ESTRVCLQPI RGVEGSDYIN
     ASFIDGYRQQ KAYIATQGPL AETTEDFWRM LWEHNSTIVV MLTKLREMGR EKCHQYWPAE
     RSARYQYFVV DPMAEYNMPQ YILREFKVTD ARDGQSRTVR QFQFTDWPEQ GVPKSGEGFI
     DFIGQVHKTK EQFGQDGPIS VHCSAGVGRT GVFITLSIVL ERMRYEGVVD IFQTVKMLRT
     QRPAMVQTEE ISHKERGKCL QCKKKFRPGI TRQRLNKLFQ VTEIRCGKSQ ENYI
//
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