ID A0A1S3FZC6_DIPOR Unreviewed; 361 AA.
AC A0A1S3FZC6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating {ECO:0000313|RefSeq:XP_012881393.1, ECO:0000313|RefSeq:XP_012881394.1};
GN Name=Nsdhl {ECO:0000313|RefSeq:XP_012881393.1,
GN ECO:0000313|RefSeq:XP_012881394.1};
OS Dipodomys ordii (Ord's kangaroo rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Heteromyidae;
OC Dipodomyinae; Dipodomys.
OX NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012881394.1};
RN [1] {ECO:0000313|RefSeq:XP_012881393.1, ECO:0000313|RefSeq:XP_012881394.1}
RP IDENTIFICATION.
RC TISSUE=Kidney {ECO:0000313|RefSeq:XP_012881393.1,
RC ECO:0000313|RefSeq:XP_012881394.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219, ECO:0000256|RuleBase:RU004475}.
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DR RefSeq; XP_012881393.1; XM_013025939.1.
DR RefSeq; XP_012881394.1; XM_013025940.1.
DR STRING; 10020.ENSDORP00000020431; -.
DR GeneID; 105992860; -.
DR KEGG; dord:105992860; -.
DR CTD; 50814; -.
DR OMA; STAHWFD; -.
DR OrthoDB; 1133at2759; -.
DR Proteomes; UP000081671; Unplaced.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0005811; C:lipid droplet; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:Ensembl.
DR GO; GO:0001942; P:hair follicle development; IEA:Ensembl.
DR GO; GO:0060716; P:labyrinthine layer blood vessel development; IEA:Ensembl.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|RuleBase:RU004475};
KW Oxidoreductase {ECO:0000256|RuleBase:RU004475};
KW Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU004475};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU004475}.
FT TRANSMEM 286..306
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU004475"
FT DOMAIN 30..280
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 361 AA; 40435 MW; A72179B2C014B181 CRC64;
MEQAVGEPIR DQGAQTLLTE DILKVKKCTV IGGSGFLGQH MVEQLLARGY TVNVFDIRQG
FDNPRVHFFL GDLCSQQDLY PALKGVSTVF HCASPPPSSN NKELFYRVNF TGTKNVIETC
RKAGVQKLIL TSSASVIFEG TDIKNGTEDL PYAMKPIDYY TETKILQEKA VLDANNPEKN
FLTIAIRPHG IFGPRDPQLV PILVEAAKKG KMKFMIGNGE NLVDFTFVEN VVHGHILAAE
RLSYNATLGG KAFHITNDEP IPFWTFLSRI LTGLNYEAPK YHIPYWVAYY LALLLSLLVM
VLSPVIQLHP TFTPMRVALA GTFHYYSCEK AKKVIGYQPV VTLDEAVERT VQSFHHLRKV
K
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