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Database: UniProt
Entry: A0A1S3FZN6_DIPOR
LinkDB: A0A1S3FZN6_DIPOR
Original site: A0A1S3FZN6_DIPOR 
ID   A0A1S3FZN6_DIPOR        Unreviewed;      1890 AA.
AC   A0A1S3FZN6;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   05-JUN-2019, entry version 15.
DE   SubName: Full=receptor-type tyrosine-protein phosphatase delta isoform X3 {ECO:0000313|RefSeq:XP_012881850.1};
GN   Name=Ptprd {ECO:0000313|RefSeq:XP_012881850.1};
OS   Dipodomys ordii (Ord's kangaroo rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha;
OC   Heteromyidae; Dipodomyinae; Dipodomys.
OX   NCBI_TaxID=10020 {ECO:0000313|Proteomes:UP000081671, ECO:0000313|RefSeq:XP_012881850.1};
RN   [1] {ECO:0000313|RefSeq:XP_012881850.1}
RP   IDENTIFICATION.
RC   TISSUE=Kidney {ECO:0000313|RefSeq:XP_012881850.1};
RG   RefSeq;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein]
CC         + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136,
CC         Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48;
CC         Evidence={ECO:0000256|SAAS:SAAS01128831};
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DR   RefSeq; XP_012881850.1; XM_013026396.1.
DR   GeneID; 105993216; -.
DR   CTD; 5789; -.
DR   OrthoDB; 220353at2759; -.
DR   Proteomes; UP000081671; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR   CDD; cd00063; FN3; 8.
DR   Gene3D; 2.60.40.10; -; 11.
DR   Gene3D; 3.90.190.10; -; 2.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000242; PTPase_domain.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   InterPro; IPR000387; TYR_PHOSPHATASE_dom.
DR   Pfam; PF00041; fn3; 7.
DR   Pfam; PF07679; I-set; 2.
DR   Pfam; PF00102; Y_phosphatase; 2.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM00060; FN3; 8.
DR   SMART; SM00409; IG; 4.
DR   SMART; SM00408; IGc2; 3.
DR   SMART; SM00194; PTPc; 2.
DR   SMART; SM00404; PTPc_motif; 2.
DR   SUPFAM; SSF48726; SSF48726; 3.
DR   SUPFAM; SSF49265; SSF49265; 5.
DR   SUPFAM; SSF52799; SSF52799; 2.
DR   PROSITE; PS50853; FN3; 8.
DR   PROSITE; PS50835; IG_LIKE; 3.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000081671};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00160,
KW   ECO:0000256|SAAS:SAAS01031440};
KW   Membrane {ECO:0000256|SAAS:SAAS00841963, ECO:0000256|SAM:Phobius};
KW   Protein phosphatase {ECO:0000256|SAAS:SAAS01031415};
KW   Receptor {ECO:0000313|RefSeq:XP_012881850.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000081671};
KW   Repeat {ECO:0000256|SAAS:SAAS00923712};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00742775,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00747680,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21   1890       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5010189728.
FT   TRANSMEM   1245   1268       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       24    114       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      126    215       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      223    305       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      312    402       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      407    503       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      505    594       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      599    696       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      701    800       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      801    894       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      899    994       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      998   1084       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN     1335   1590       Tyrosine-protein phosphatase.
FT                                {ECO:0000259|PROSITE:PS50055}.
FT   DOMAIN     1510   1581       TYR_PHOSPHATASE_2. {ECO:0000259|PROSITE:
FT                                PS50056}.
FT   DOMAIN     1622   1881       Tyrosine-protein phosphatase.
FT                                {ECO:0000259|PROSITE:PS50055}.
FT   DOMAIN     1799   1872       TYR_PHOSPHATASE_2. {ECO:0000259|PROSITE:
FT                                PS50056}.
FT   REGION      589    610       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1S3FZN6}.
FT   REGION     1277   1296       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A1S3FZN6}.
FT   ACT_SITE   1531   1531       Phosphocysteine intermediate.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00160}.
FT   ACT_SITE   1822   1822       Phosphocysteine intermediate.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00160}.
SQ   SEQUENCE   1890 AA;  212127 MW;  A7A1A9480C12A95F CRC64;
     MVHITRPLLL LLAFFLRVDA ETPPRFTRTP VDQTGVSGGV ASFICQATGD PRPKIVWNKK
     GKKVSNQRFE VIEFDDGSGS VLRIQPLRTP RDEAIYECVA SNNVGEISVS TRLTVLREDQ
     IPRGFPTIDM GPQLKVVERT RTATMLCAAS GNPDPEITWF KDFLPVDTSN NNGRIKQLRS
     GALQIEQSEE SDQGKYECVA TNSAGTRYSA PANLYVRVRR VPPRFSIPPT NHEIMPGGSV
     NITCVAVGSP MPYVKWMLGA EDLTPEDDMP IGRNVLELND VRQSANYTCV AMSTLGVIEA
     IAQITVKALP KPPGTPVVTE STATSITLTW DSGNPEPVSY YIIQHKPKNS EEPYKEIDGV
     ATTRYSVAGL SPYSDYEFRV VAVNNIGRGP PSEPVLTQTS EQAPSSAPRD VQARMLSSTT
     ILVQWKEPEE PNGQIQGYRV YYTMDPTQHV NNWMKHNVAD SQITTIGNLV PQKTYSVKVL
     AFTSIGDGPL SSDIQVITQT GVPGQPLNFK AEPESETSIL LSWTPPRSDT IASYELVYKD
     GELGEEQRVT IEPGTSYRLQ GLKPNSLYYF RLAARSPQGL GASTTEISAR TMQSKPSAPP
     QDISCTSPSS TSILVSWQPP PVEKQNGIIT EYSLKYIAVD GEDDKPHEVL GIPSDTTKYL
     LEQLEKWTEY RITVTAHTDV GPGPESLSIL IRTDEDVPSG PPRKVEVEAV NSTSVKVSWR
     SPVPNKQHGQ IRGYQVHYVR MENGEPKGQP MLKDVMLADA QDMIISGLQP ETSYSLTVTA
     YTTKGDGARS KPKLVSTTGA VPGKPRLVIN HTQMNTALIQ WHPPVDTFGP LQGYRLKFGR
     KDMEPLTTLE FSEKEDHFTA TDIHKGASYV FRLSARNKVG FGEEMVKEIT VPEEIPTGFP
     QNLHSEGTTS TSVQLSWQPP VLAERNGIIT KYTLLYRDIN IPLHPLEQLL VPADTSMTLT
     GLKPDTTYDV KVRAHTSKGP GPYSPSVQFR TLPVDQVFAK NFHVKAVMKT SVLLSWEIPE
     NYNSAMPFKI LYDDGKMVEE VDGRATQKLI VNLKPEKSYS FVLTNRGNSA GGLQHRVTAK
     TAPDVLRTKP AFIGKTNLDG MITVQLPEVP ANENIKGYYI IIVPLKKSRG KFIKPWESPD
     EMELDELLKE ISRKRRSIRY GREVELKPYI AAHFDVLPTE FTLGDDKHYG GFTNKQLQSG
     QEYVFFVLAV MEHAESKMYA TSPYSDPVVS MDLDPQPITD EEEGLIWVVG PVLAVVFIIC
     IVIAILLYKR KRAESESRKS SIPNSKEVPS HHPTDPVELR RLNFQTPGMA SHPPIPILEL
     ADHIERLKAN DNLKFSQEYE SIDPGQQFTW EHSNLEVNKP KNRYANVIAY DHSRVLLSAI
     EGIPGSDYVN ANYIDGYRKQ NAYIATQGSL PETFGDFWRM IWEQRSATIV MMTKLEERSR
     VKCDQYWPSR GTETHGLVQV TLLDTVELAT YCVRTFALYK NGSSEKREVR QFQFTAWPDH
     GVPEHPTPFL AFLRRVKTCN PPDAGPMVVH CSAGVGRTGC FIVIDAMLER IKHEKTVDIY
     GHVTLMRAQR NYMVQTEDQY IFIHDALLEA VTCGNTEVPA RNLYAYIQKL TQIETGENVT
     GMELEFKRLA SSKAHTSRFI SANLPCNKFK NRLVNIMPYE STRVCLQPIR GVEGSDYINA
     SFIDGYRQQK AYIATQGPLA ETTEDFWRML WEHNSTIVVM LTKLREMGRE KCHQYWPAER
     SARYQYFVVD PMAEYNMPQY ILREFKVTDA RDGQSRTVRQ FQFTDWPEQG VPKSGEGFID
     FIGQVHKTKE QFGQDGPISV HCSAGVGRTG VFITLSIVLE RMRYEGVVDI FQTVKMLRTQ
     RPAMVQTEDQ YQFCYRAALE YLGSFDHYAT
//
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